SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Waldenberger Melanie)
 

Sökning: WFRF:(Waldenberger Melanie) > G protein-coupled r...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007584naa a2200625 4500
001oai:DiVA.org:umu-211834
003SwePub
008230711s2023 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2118342 URI
0247 a https://doi.org/10.3390/ijms240101802 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Haase, Tinau University Heart & Vascular Center Hamburg, Department of Cardiology, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg, Kiel, Lübeck, Hamburg, Germany4 aut
2451 0a G protein-coupled receptor 15 expression is associated with myocardial infarction
264 c 2022-12-22
264 1b MDPI,c 2023
338 a electronic2 rdacarrier
520 a Beyond the influence of lifestyle-related risk factors for myocardial infarction (MI), the mechanisms of genetic predispositions for MI remain unclear. We sought to identify and characterize differentially expressed genes in early-onset MI in a translational approach. In an observational case–control study, transcriptomes from 112 early-onset MI individuals showed upregulated G protein-coupled receptor 15 (GPR15) expression in peripheral blood mononuclear cells compared to controls (fold change = 1.4, p = 1.87 × 10−7). GPR15 expression correlated with intima-media thickness (β = 0.8498, p = 0.111), C-reactive protein (β = 0.2238, p = 0.0052), ejection fraction (β = −0.9991, p = 0.0281) and smoking (β = 0.7259, p = 2.79 × 10−10). The relation between smoking and MI was diminished after the inclusion of GPR15 expression as mediator in mediation analysis (from 1.27 (p = 1.9 × 10−5) to 0.46 (p = 0.21)). The DNA methylation of two GPR15 sites was 1%/5% lower in early-onset MI individuals versus controls (p = 2.37 × 10−6/p = 0.0123), with site CpG3.98251219 significantly predicting risk for incident MI (hazard ratio = 0.992, p = 0.0177). The nucleotide polymorphism rs2230344 (C/T) within GPR15 was associated with early-onset MI (odds ratio = 3.61, p = 0.044). Experimental validation showed 6.3-fold increased Gpr15 expression in an ischemic mouse model (p < 0.05) and 4-fold increased Gpr15 expression in cardiomyocytes under ischemic stress (p < 0.001). After the induction of MI, Gpr15gfp/gfp mice showed lower survival (p = 0.042) and deregulated gene expression for response to hypoxia and signaling pathways. Using a translational approach, our data provide evidence that GPR15 is linked to cardiovascular diseases, mediating the adverse effects of smoking.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
653 a biomarkers
653 a cardiovascular disease
653 a epigenetics
653 a G protein-coupled receptor
653 a gene expression
653 a inflammation
653 a novel molecular target
653 a pathogenesis
653 a signal pathway
653 a translational research
7001 a Müller, Christianu University Heart & Vascular Center Hamburg, Department of Cardiology, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg, Kiel, Lübeck, Hamburg, Germany4 aut
7001 a Stoffers, Bastianu University Heart & Vascular Center Hamburg, Department of Cardiology, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg, Kiel, Lübeck, Hamburg, Germany4 aut
7001 a Kirn, Philippu German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg, Kiel, Lübeck, Hamburg, Germany; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany4 aut
7001 a Waldenberger, Melanieu Research Unit Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Munich, Neuherberg, Germany4 aut
7001 a Kaiser, Frank J.u Institute of Human Genetics, University Hospital Essen, University Duisburg-Essen, Essen, Germany4 aut
7001 a Karakas, Mahiru German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg, Kiel, Lübeck, Hamburg, Germany; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany4 aut
7001 a Kim, Sangwon V.u Department of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, PA, Philadelphia, United States4 aut
7001 a Voss, Svenjau University Heart & Vascular Center Hamburg, Department of Cardiology, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg, Kiel, Lübeck, Hamburg, Germany4 aut
7001 a Wild, Philipp S.u Preventive Cardiology and Preventive Medicine, Department of Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany; Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany4 aut
7001 a Lackner, Karl J.u German Centre for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany; Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany4 aut
7001 a Andersson, Jonas,d 1977-u Umeå universitet,Institutionen för folkhälsa och klinisk medicin4 aut0 (Swepub:umu)jasaon96
7001 a Söderberg, Stefanu Umeå universitet,Institutionen för folkhälsa och klinisk medicin4 aut0 (Swepub:umu)stso0001
7001 a Lindner, Dianau University Heart & Vascular Center Hamburg, Department of Cardiology, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg, Kiel, Lübeck, Hamburg, Germany4 aut
7001 a Zeller, Tanjau German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg, Kiel, Lübeck, Hamburg, Germany; University Center of Cardiovascular Science, University Heart Vascular Center Hamburg, Hamburg, Germany4 aut
7102 a University Heart & Vascular Center Hamburg, Department of Cardiology, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg, Kiel, Lübeck, Hamburg, Germanyb German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg, Kiel, Lübeck, Hamburg, Germany; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany4 org
7730 t International Journal of Molecular Sciencesd : MDPIg 24:1q 24:1x 1661-6596x 1422-0067
8564 u https://doi.org/10.3390/ijms24010180y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1781805/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-211834
8564 8u https://doi.org/10.3390/ijms24010180

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy