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MS-based lipidomics...
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Burla, BoSingapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore
(författare)
MS-based lipidomics of human blood plasma : a community-initiated position paper to develop accepted guidelines
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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American Society for Biochemistry and Molecular Biology,2018
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-69218
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-69218URI
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https://doi.org/10.1194/jlr.S087163DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:139231780URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies:National University of Singapore via the Life Sciences Institute National Research Foundation Singapore Grant NRFI2015-05 Deutsche Forschungsgemeinschaft TRR83 LiSyM Consortium - Bundesministerium fur Bildung und Forschung, Germany Foundation for the National Institutes of Health U54 GM069338 RO1 GM20501-41 Japan Agency for Medical Research and Development Grant JP18gm5910001 National Health and Medical Research Council of Australia Japan Society for the Promotion of Science 15H05897 15H05898 17H03621 Japan Agency for Medical Research and Development Grants 17gm0910005h0403 17gm1010006h0001 National Bioscience Database Center Togo Project, Japan Biotechnology and Biological Sciences Research Council Grant BB/P013384/1 Medical Research Council Grant MR/M004821/1 Academy of Finland Grant 292568 European Commission Project LITMUS Grant 777377 National Institute of General Medical Sciences Grant R01 GM105724
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Human blood is a self-regenerating lipid-rich biological fluid that is routinely collected in hospital settings. The inventory of lipid molecules found in blood plasma (plasma lipidome) offers insights into individual metabolism and physiology in health and disease. Disturbances in the plasma lipidome also occur in conditions that are not directly linked to lipid metabolism; therefore, plasma lipidomics based on MS is an emerging tool in an array of clinical diagnostics and disease management. However, challenges exist in the translation of such lipidomic data to clinical applications. These relate to the reproducibility, accuracy, and precision of lipid quantitation, study design, sample handling, and data sharing. This position paper emerged from a workshop that initiated a community-led process to elaborate and define a set of generally accepted guidelines for quantitative MS-based lipidomics of blood plasma or serum, with harmonization of data acquired on different instrumentation platforms across independent laboratories as an ultimate goal. We hope that other fields may benefit from and follow such a precedent.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Arita, MakotoLaboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Cellular and Molecular Epigenetics Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan; Division of Physiological Chemistry and Metabolism, Keio University Faculty of Pharmacy, Tokyo, Japan
(författare)
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Arita, MasanoriNational Institute of Genetics, Shizuoka, Japan and RIKEN Center for Sustainable Resource Science, Yokohama, Japan
(författare)
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Bendt, Anne K.Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore
(författare)
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Cazenave-Gassiot, AmauryDepartment of Biochemistry, YLL School of Medicine, National University of Singapore, Singapore
(författare)
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Dennis, Edward A.Departments of Pharmacology and Chemistry and Biochemistry, School of Medicine, University of California at San Diego, La Jolla, CA, USA
(författare)
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Ekroos, KimLipidomics Consulting Ltd., Esbo, Finland
(författare)
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Han, XianlinBarshop Institute for Longevity and Aging Studies and Department of Medicine-Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
(författare)
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Ikeda, KazutakaLaboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Cellular and Molecular Epigenetics Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan
(författare)
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Liebisch, GerhardInstitute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany
(författare)
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Lin, Michelle K.Department of Biochemistry, YLL School of Medicine, National University of Singapore, Singapore
(författare)
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Loh, Tze PingDepartment of Laboratory Medicine, National University Hospital, Singapore
(författare)
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Meikle, Peter J.Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia
(författare)
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Orešič, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,Turku Centre for Biotechnology, University of Turku, Turku, Finland; Åbo Akademi University, Turku, Finland(Swepub:oru)moc
(författare)
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Quehenberger, OswaldDepartments of Pharmacology and Medicine, School of Medicine, University of California at San Diego, La Jolla, CA, USA
(författare)
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Shevchenko, AndrejMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
(författare)
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Torta, FedericoDepartment of Biochemistry, YLL School of Medicine, National University of Singapore, Singapore
(författare)
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Wakelam, Michael J. O.Babraham Institute, Cambridge, United Kingdom
(författare)
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Wheelock, Craig E.Karolinska Institutet
(författare)
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Wenk, Markus R.Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore; Department of Biochemistry, YLL School of Medicine, National University of Singapore, Singapore
(författare)
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Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, SingaporeLaboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Cellular and Molecular Epigenetics Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan; Division of Physiological Chemistry and Metabolism, Keio University Faculty of Pharmacy, Tokyo, Japan
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Lipid Research: American Society for Biochemistry and Molecular Biology59:10, s. 2001-20170022-22751539-7262
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Till lärosätets databas
- Av författaren/redakt...
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Burla, Bo
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Arita, Makoto
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Arita, Masanori
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Bendt, Anne K.
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Cazenave-Gassiot ...
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Dennis, Edward A ...
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visa fler...
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Ekroos, Kim
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Han, Xianlin
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Ikeda, Kazutaka
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Liebisch, Gerhar ...
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Lin, Michelle K.
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Loh, Tze Ping
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Meikle, Peter J.
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Orešič, Matej, 1 ...
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Quehenberger, Os ...
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Shevchenko, Andr ...
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Torta, Federico
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Wakelam, Michael ...
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Wheelock, Craig ...
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Wenk, Markus R.
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visa färre...
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MEDICIN OCH HÄLS ...
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och Medicinsk biotek ...
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och Biomedicinsk lab ...
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Journal of Lipid ...
- Av lärosätet
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Örebro universitet
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Karolinska Institutet