Mild-to-moderate kidney dysfunction and cardiovascular disease: Observational and mendelian randomization analyses

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Fältnamn	Indikatorer	Metadata
000		11110naa a2202053 4500
001		oai:DiVA.org:umu-202685
003		SwePub
008		230112s2022 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
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009		oai:lup.lub.lu.se:5fe19d8e-bc8b-4d5a-9289-bad257428518
009		oai:gup.ub.gu.se/319719
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2026852 URI
024	7	a https://doi.org/10.1161/CIRCULATIONAHA.122.0607002 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:du-431522 URI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4914332 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1515048832 URI
024	7	a https://lup.lub.lu.se/record/5fe19d8e-bc8b-4d5a-9289-bad2574285182 URI
024	7	a https://gup.ub.gu.se/publication/3197192 URI
040		a (SwePub)umud (SwePub)dud (SwePub)uud (SwePub)kid (SwePub)lud (SwePub)gu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Gaziano, Liamu University of Cambridge,Boston Veteran's Administration (VA) Healthcare4 aut
245	1 0	a Mild-to-moderate kidney dysfunction and cardiovascular disease :b Observational and mendelian randomization analyses
264	1	b Wolters Kluwer,c 2022
338		a electronic2 rdacarrier
520		a BACKGROUND: End-stage renal disease is associated with a high risk of cardiovascular events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally related to coronary heart disease (CHD) and stroke.METHODS: Observational analyses were conducted using individual-level data from 4 population data sources (Emerging Risk Factors Collaboration, EPIC-CVD [European Prospective Investigation into Cancer and Nutrition-Cardiovascular Disease Study], Million Veteran Program, and UK Biobank), comprising 648 135 participants with no history of cardiovascular disease or diabetes at baseline, yielding 42 858 and 15 693 incident CHD and stroke events, respectively, during 6.8 million person-years of follow-up. Using a genetic risk score of 218 variants for estimated glomerular filtration rate (eGFR), we conducted Mendelian randomization analyses involving 413 718 participants (25 917 CHD and 8622 strokes) in EPIC-CVD, Million Veteran Program, and UK Biobank.RESULTS: There were U-shaped observational associations of creatinine-based eGFR with CHD and stroke, with higher risk in participants with eGFR values <60 or >105 mL·min-1·1.73 m-2, compared with those with eGFR between 60 and 105 mL·min-1·1.73 m-2. Mendelian randomization analyses for CHD showed an association among participants with eGFR <60 mL·min-1·1.73 m-2, with a 14% (95% CI, 3%-27%) higher CHD risk per 5 mL·min-1·1.73 m-2 lower genetically predicted eGFR, but not for those with eGFR >105 mL·min-1·1.73 m-2. Results were not materially different after adjustment for factors associated with the eGFR genetic risk score, such as lipoprotein(a), triglycerides, hemoglobin A1c, and blood pressure. Mendelian randomization results for stroke were nonsignificant but broadly similar to those for CHD.CONCLUSIONS: In people without manifest cardiovascular disease or diabetes, mild-to-moderate kidney dysfunction is causally related to risk of CHD, highlighting the potential value of preventive approaches that preserve and modulate kidney function.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Allmänmedicin0 (SwePub)302242 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex General Practice0 (SwePub)302242 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653		a cardiovascular diseases
653		a coronary disease
653		a kidney diseases
653		a stroke
653		a cardiovascular diseases
653		a coronary disease
653		a kidney diseases
653		a stroke
700	1	a Sun, Luanluan4 aut
700	1	a Arnold, Matthew4 aut
700	1	a Bell, Steven4 aut
700	1	a Cho, Kelly4 aut
700	1	a Kaptoge, Stephen K.4 aut
700	1	a Song, Rebecca J.4 aut
700	1	a Burgess, Stephen4 aut
700	1	a Posner, Daniel C.4 aut
700	1	a Mosconi, Katja4 aut
700	1	a Robinson-Cohen, Cassianne4 aut
700	1	a Mason, Amy M.4 aut
700	1	a Bolton, Thomas R.4 aut
700	1	a Tao, Ran4 aut
700	1	a Allara, Elias4 aut
700	1	a Schubert, Petra4 aut
700	1	a Chen, Lingyan4 aut
700	1	a Staley, James R.4 aut
700	1	a Staplin, Natalie4 aut
700	1	a Altay, Servet4 aut
700	1	a Amiano, Pilar4 aut
700	1	a Arndt, Volker4 aut
700	1	a Ärnlöv, Johan,d 1970-u Karolinska Institutet,Högskolan Dalarna,Medicinsk vetenskap4 aut0 (Swepub:du)jan
700	1	a Barr, Elizabeth L. M.4 aut
700	1	a Björkelund, Cecilia4 aut
700	1	a Boer, Jolanda M. A.4 aut
700	1	a Brenner, Hermann4 aut
700	1	a Casiglia, Edoardo4 aut
700	1	a Chiodini, Paolo4 aut
700	1	a Cooper, Jackie A.4 aut
700	1	a Coresh, Josef4 aut
700	1	a Cushman, Mary4 aut
700	1	a Dankner, Rachel4 aut
700	1	a Davidson, Karina W.4 aut
700	1	a de Jongh, Renate T.4 aut
700	1	a Donfrancesco, Chiara4 aut
700	1	a Engström, G.u Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)smi-gen
700	1	a Freisling, Heinz4 aut
700	1	a de la Cámara, Agustín Gómez4 aut
700	1	a Gudnason, Vilmundur4 aut
700	1	a Hankey, Graeme J.4 aut
700	1	a Hansson, Per-Olof,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Extern,Institute of Medicine, Department of Molecular and Clinical Medicine,External4 aut0 (Swepub:gu)xhanpm
700	1	a Heath, Alicia K.4 aut
700	1	a Hoorn, Ewout J.4 aut
700	1	a Imano, Hironori4 aut
700	1	a Jassal, Simerjot K.4 aut
700	1	a Kaaks, Rudolf4 aut
700	1	a Katzke, Verena4 aut
700	1	a Kauhanen, Jussi4 aut
700	1	a Kiechl, Stefan4 aut
700	1	a Koenig, Wolfgang4 aut
700	1	a Kronmal, Richard A.4 aut
700	1	a Kyrø, Cecilie4 aut
700	1	a Lawlor, Deborah A.4 aut
700	1	a Ljungberg, Börje,c Professor,d 1949-u Umeå universitet,Urologi och andrologi4 aut0 (Swepub:umu)bolj0001
700	1	a MacDonald, Conor4 aut
700	1	a Masala, Giovanna4 aut
700	1	a Meisinger, Christa4 aut
700	1	a Melander, O.u Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome
700	1	a Moreno Iribas, Conchi4 aut
700	1	a Ninomiya, Toshiharu4 aut
700	1	a Nitsch, Dorothea4 aut
700	1	a Nordestgaard, Børge G.4 aut
700	1	a Onland-Moret, Charlotte4 aut
700	1	a Palmieri, Luigi4 aut
700	1	a Petrova, Dafina4 aut
700	1	a Garcia, Jose Ramón Quirós4 aut
700	1	a Rosengren, Annika,d 1951u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xrosan
700	1	a Sacerdote, Carlotta4 aut
700	1	a Sakurai, Masaru4 aut
700	1	a Santiuste, Carmen4 aut
700	1	a Schulze, Matthias B.4 aut
700	1	a Sieri, Sabina4 aut
700	1	a Sundström, Johan,c Professor,d 1971-u Uppsala universitet,Klinisk epidemiologi4 aut0 (Swepub:uu)johasund
700	1	a Tikhonoff, Valérie4 aut
700	1	a Tjønneland, Anne4 aut
700	1	a Tong, Tammy4 aut
700	1	a Tumino, Rosario4 aut
700	1	a Tzoulaki, Ioanna4 aut
700	1	a van der Schouw, Yvonne T.4 aut
700	1	a Monique Verschuren, W. M.4 aut
700	1	a Völzke, Henry4 aut
700	1	a Wallace, Robert B.4 aut
700	1	a Wannamethee, S. Goya4 aut
700	1	a Weiderpass, Elisabete4 aut
700	1	a Willeit, Peter4 aut
700	1	a Woodward, Mark4 aut
700	1	a Yamagishi, Kazumasa4 aut
700	1	a Zamora-Ros, Raul4 aut
700	1	a Akwo, Elvis A.4 aut
700	1	a Pyarajan, Saiju4 aut
700	1	a Gagnon, David R.4 aut
700	1	a Tsao, Philip S.4 aut
700	1	a Muralidhar, Sumitra4 aut
700	1	a Edwards, Todd L.4 aut
700	1	a Damrauer, Scott M.4 aut
700	1	a Joseph, Jacob4 aut
700	1	a Pennells, Lisa4 aut
700	1	a Wilson, Peter W. F.4 aut
700	1	a Harrison, Seamus4 aut
700	1	a Gaziano, Thomas A.4 aut
700	1	a Inouye, Michael4 aut
700	1	a Baigent, Colin4 aut
700	1	a Casas, Juan P.4 aut
700	1	a Langenberg, Claudia4 aut
700	1	a Wareham, Nick4 aut
700	1	a Riboli, Elio4 aut
700	1	a Gaziano, J. Michael4 aut
700	1	a Danesh, John4 aut
700	1	a Hung, Adriana M.4 aut
700	1	a Butterworth, Adam S.4 aut
700	1	a Wood, Angela M.4 aut
700	1	a Di Angelantonio, Emanueleu Human Technopole,University of Cambridge4 aut
700	1	a OnlandMoret, C4 aut
700	1	a ZamoraRos, R4 aut
710	2	a University of Cambridgeb Boston Veteran's Administration (VA) Healthcare4 org
710	2	a Emerging Risk Factors Collaboration
710	2	a The Million Veteran Program
710	2	a et al.
773	0	t Circulationd : Wolters Kluwerg 146:20, s. 1507-1517q 146:20<1507-1517x 0009-7322x 1524-4539
856	4	u https://doi.org/10.1161/CIRCULATIONAHA.122.060700y Fulltext
856	4	u https://umu.diva-portal.org/smash/get/diva2:1726203/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://uu.diva-portal.org/smash/get/diva2:1721196/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u http://dx.doi.org/10.1161/CIRCULATIONAHA.122.060700x freey FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-202685
856	4 8	u https://doi.org/10.1161/CIRCULATIONAHA.122.060700
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:du-43152
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-491433
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:151504883
856	4 8	u https://lup.lub.lu.se/record/5fe19d8e-bc8b-4d5a-9289-bad257428518
856	4 8	u https://gup.ub.gu.se/publication/319719

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Av författaren/redakt...: Gaziano, Liam; Sun, Luanluan; Arnold, Matthew; Bell, Steven; Cho, Kelly; Kaptoge, Stephen ...; visa fler...; Song, Rebecca J.; Burgess, Stephen; Posner, Daniel C ...; Mosconi, Katja; Robinson-Cohen, ...; Mason, Amy M.; Bolton, Thomas R ...; Tao, Ran; Allara, Elias; Schubert, Petra; Chen, Lingyan; Staley, James R.; Staplin, Natalie; Altay, Servet; Amiano, Pilar; Arndt, Volker; Ärnlöv, Johan, 1 ...; Barr, Elizabeth ...; Björkelund, Ceci ...; Boer, Jolanda M. ...; Brenner, Hermann; Casiglia, Edoard ...; Chiodini, Paolo; Cooper, Jackie A ...; Coresh, Josef; Cushman, Mary; Dankner, Rachel; Davidson, Karina ...; de Jongh, Renate ...; Donfrancesco, Ch ...; Engström, G.; Freisling, Heinz; de la Cámara, Ag ...; Gudnason, Vilmun ...; Hankey, Graeme J ...; Hansson, Per-Olo ...; Heath, Alicia K.; Hoorn, Ewout J.; Imano, Hironori; Jassal, Simerjot ...; Kaaks, Rudolf; Katzke, Verena; Kauhanen, Jussi; Kiechl, Stefan; Koenig, Wolfgang; Kronmal, Richard ...; Kyrø, Cecilie; Lawlor, Deborah ...; Ljungberg, Börje ...; MacDonald, Conor; Masala, Giovanna; Meisinger, Chris ...; Melander, O.; Moreno Iribas, C ...; Ninomiya, Toshih ...; Nitsch, Dorothea; Nordestgaard, Bø ...; Onland-Moret, Ch ...; Palmieri, Luigi; Petrova, Dafina; Garcia, Jose Ram ...; Rosengren, Annik ...; Sacerdote, Carlo ...; Sakurai, Masaru; Santiuste, Carme ...; Schulze, Matthia ...; Sieri, Sabina; Sundström, Johan ...; Tikhonoff, Valér ...; Tjønneland, Anne; Tong, Tammy; Tumino, Rosario; Tzoulaki, Ioanna; van der Schouw, ...; Monique Verschur ...; Völzke, Henry; Wallace, Robert ...; Wannamethee, S. ...; Weiderpass, Elis ...; Willeit, Peter; Woodward, Mark; Yamagishi, Kazum ...; Zamora-Ros, Raul; Akwo, Elvis A.; Pyarajan, Saiju; Gagnon, David R.; Tsao, Philip S.; Muralidhar, Sumi ...; Edwards, Todd L.; Damrauer, Scott ...; Joseph, Jacob; Pennells, Lisa; Wilson, Peter W. ...; Harrison, Seamus; Gaziano, Thomas ...; Inouye, Michael; Baigent, Colin; Casas, Juan P.; Langenberg, Clau ...; Wareham, Nick; Riboli, Elio; Gaziano, J. Mich ...; Danesh, John; Hung, Adriana M.; Butterworth, Ada ...; Wood, Angela M.; Di Angelantonio, ...; OnlandMoret, C; ZamoraRos, R; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin

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