Sökning: WFRF:(Askmalm Stenmark Marie) >
Protein accumulatio...
Protein accumulation and gene mutation of p53 in bilateral breast cancer
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- Stenmark-Askmalm, Askmalm Marie, 1966- (författare)
- Linköpings universitet,Onkologi,Hälsouniversitetet
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- Gentile, Massimiliano (författare)
- Linköpings universitet,Onkologi,Hälsouniversitetet
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- Wingren, Sten, 1950- (författare)
- Linköpings universitet,Onkologi,Hälsouniversitetet
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- Stål, Olle, 1952- (författare)
- Linköpings universitet,Onkologi,Hälsouniversitetet
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- Arnesson, Lars-Gunnar, 1947- (författare)
- Linköpings universitet,Kirurgi,Hälsouniversitetet
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(creator_code:org_t)
- 2009-07-08
- 2001
- Engelska.
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Ingår i: Acta Oncologica. - : Informa UK Limited. - 0284-186X .- 1651-226X. ; 40:1, s. 56-62
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The aim of this study was to investigate the frequency of p53 alterations in bilateral breast cancer and to evaluate a possible clonal relationship between the paired tumours regarding p53 alteration and other pathobiological variables. Tumours from 34 patients were investigated with immunohistochemistry, single strand conformation polymorphism analysis and DNA-sequence analysis applied to exons 5-8. Fifteen percent of the 68 tumours showed positive immunoreaction and/or presence of mutation. The occurrence of p53 accumulation was 9% and the prevalence of gene mutation 10%. No significant concordance was found between the tumours in the same patient for p53 alterations, progesterone receptor status or DNA ploidy. S-phase fraction showed a weak correlation, not statistically significant. Oestrogen receptor status was the only variable that exhibited a significant concordance. No convincing evidence was found for other associations between the paired tumours or for a high prevalence of p53 alterations in bilateral breast cancer.
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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