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Search: WFRF:(Chen Gary K.) > (2020-2024) > Comprehensive funct...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007923naa a2201033 4500
001oai:DiVA.org:umu-175463
003SwePub
008201002s2021 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:c7d705a1-e2d8-4451-b44c-038d6c0ddb5b
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1754632 URI
0247 a https://doi.org/10.1007/s11684-020-0779-42 DOI
0247 a https://lup.lub.lu.se/record/c7d705a1-e2d8-4451-b44c-038d6c0ddb5b2 URI
040 a (SwePub)umud (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Qin, Nau Nanjing Medical University4 aut
2451 0a Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma
264 c 2020-09-05
264 1b Springer-Verlag New York,c 2021
338 a print2 rdacarrier
520 a Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer (NSCLC) risk, biological mechanisms of these variants remain largely unknown. By integrating a large-scale genotype data of 15 581 lung adenocarcinoma (AD) cases, 8350 squamous cell carcinoma (SqCC) cases, and 27 355 controls, as well as multiple transcriptome and epigenomic databases, we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants. We identified 3064 credible risk variants for NSCLC, which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites. Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific. Functional annotation and gene-based analysis implicated 894 target genes, including 274 specifics for AD and 123 for SqCC, which were overrepresented in somatic driver genes (ER = 1.95,P= 0.005). Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways, while SqCC genes were homologous recombination deficiency related. Our results illustrate the molecular basis of both well-studied and new susceptibility loci of NSCLC, providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
653 a lung cancer
653 a genome-wide association study
653 a function annotation
653 a immune
653 a homologous recombination repair deficiency
653 a genetic heterogeneity
653 a function annotation
653 a genetic heterogeneity
653 a genome-wide association study
653 a homologous recombination repair deficiency
653 a immune
653 a lung cancer
7001 a Li, Yuanchengu Nanjing Medical University4 aut
7001 a Wang, Chengu Nanjing Medical University4 aut
7001 a Zhu, Mengu Nanjing Medical University4 aut
7001 a Dai, Junchengu Nanjing Medical University4 aut
7001 a Hong, Tongtongu Nanjing Medical University4 aut
7001 a Albanes, Demetriusu National Cancer Institute, USA4 aut
7001 a Lam, Stephenu British Columbia Cancer Agency4 aut
7001 a Tardon, Adoninau University of Oviedo4 aut
7001 a Chen, Chuu Fred Hutchinson Cancer Research Center,Vanderbilt University,Harvard University,Nanjing Medical University4 aut
7001 a Goodman, Garyu Swedish Medical Center4 aut
7001 a Bojesen, Stig E.u Copenhagen University Hospital4 aut
7001 a Landi, Maria Teresau National Cancer Institute, USA4 aut
7001 a Johansson, Mattiasu International Agency for Research on Cancer, World Health Organization4 aut
7001 a Risch, Angelau University of Salzburg4 aut
7001 a Wichmann, H-Erichu World Orthopaedic Concern4 aut
7001 a Bickeboller, Heikeu University Medical Center Göttingen4 aut
7001 a Rennert, Gadiu Technion - Israel Institute of Technology4 aut
7001 a Arnold, Susanneu University of Kentucky Medical Center4 aut
7001 a Brennan, Paulu International Agency for Research on Cancer, World Health Organization4 aut
7001 a Field, John K.u University of Liverpool4 aut
7001 a Shete, Sanjayu University of Texas MD Anderson Cancer Center4 aut
7001 a Le Marchand, Loicu University of Hawaii at Manoa4 aut
7001 a Melander, Olleu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome
7001 a Brunnstrom, Hansu Lund University,Lunds universitet,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-hsb
7001 a Liu, Geoffreyu Princess Margaret Hospital University of Toronto4 aut
7001 a Hung, Rayjean J.u Sinai Health System4 aut
7001 a Andrew, Angelineu Dartmouth-Hitchcock Medical Center,Radboud University Nijmegen4 aut
7001 a Kiemeney, Lambertus A.4 aut
7001 a Zienolddiny, Shanu National Institute of Occupational Health, Norway4 aut
7001 a Grankvist, Kjellu Umeå University,Umeå universitet,Klinisk kemi4 aut0 (Swepub:umu)kjgr0002
7001 a Johansson, Mikaelu Umeå University,Umeå universitet,Onkologi4 aut0 (Swepub:umu)mijo0025
7001 a Caporaso, Neilu National Cancer Institute, USA4 aut
7001 a Woll, Penellau University of Sheffield4 aut
7001 a Lazarus, Philipu Washington State University4 aut
7001 a Schabath, Matthew B.u H. Lee Moffitt Cancer Center & Research Institute4 aut
7001 a Aldrich, Melinda C.4 aut
7001 a Stevens, Victoria L.u American Cancer Society4 aut
7001 a Jin, Guangfuu Nanjing Medical University4 aut
7001 a Christiani, David C.4 aut
7001 a Hu, Zhibinu Nanjing Medical University4 aut
7001 a Amos, Christopher I.u Baylor College of Medicine4 aut
7001 a Ma, Hongxiau Nanjing Medical University4 aut
7001 a Shen, Hongbingu Nanjing Medical University4 aut
7102 a Nanjing Medical Universityb National Cancer Institute, USA4 org
7730 t Frontiers of Medicined : Springer-Verlag New Yorkg 15:2, s. 275-291q 15:2<275-291x 2095-0217x 2095-0225
8564 u https://eprints.whiterose.ac.uk/177317/1/nihms-1731864.pdf
8564 u http://dx.doi.org/10.1007/s11684-020-0779-4y FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-175463
8564 8u https://doi.org/10.1007/s11684-020-0779-4
8564 8u https://lup.lub.lu.se/record/c7d705a1-e2d8-4451-b44c-038d6c0ddb5b

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