An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

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Fältnamn	Indikatorer	Metadata
000		32531naa a2202797 4500
001		oai:DiVA.org:su-148842
003		SwePub
008		171113s2017 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:umu-141797
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009		oai:DiVA.org:uu-340702
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1488422 URI
024	7	a https://doi.org/10.2337/db16-12532 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1417972 URI
024	7	a https://lup.lub.lu.se/record/5867f78e-7daa-491d-a64c-af454921c7f12 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1368765412 URI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3407022 URI
040		a (SwePub)sud (SwePub)umud (SwePub)lud (SwePub)kid (SwePub)uu
041		a engb eng
042		9 SwePub
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072	7	a art2 swepub-publicationtype
100	1	a Scott, Robert A.u University of Cambridge,Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.4 aut
245	1 0	a An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans
264		c 2017-05-31
264	1	b American Diabetes Association,c 2017
338		a print2 rdacarrier
520		a To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ancestry after imputation using the 1000 Genomes multiethnic reference panel. Promising association signals were followed up in additional data sets (of 14,545 or 7,397 T2D case and 38,994 or 71,604 control subjects). We identified 13 novel T2D-associated loci (P < 5 x 10(-8)), including variants near the GLP2R, GIP, and HLA-DQA1 genes. Our analysis brought the total number of independent T2D associations to 128 distinct signals at 113 loci. Despite substantially increased sample size and more complete coverage of low-frequency variation, all novel associations were driven by common single nucleotide variants. Credible sets of potentially causal variants were generally larger than those based on imputation with earlier reference panels, consistent with resolution of causal signals to common risk haplotypes. Stratification of T2D-associated loci based on T2D-related quantitative trait associations revealed tissue-specific enrichment of regulatory annotations in pancreatic islet enhancers for loci influencing insulin secretion and in adipocytes, monocytes, and hepatocytes for insulin action-associated loci. These findings highlight the predominant role played by common variants of modest effect and the diversity of biological mechanisms influencing T2D pathophysiology.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650	7	a NATURVETENSKAPx Data- och informationsvetenskapx Datavetenskap0 (SwePub)102012 hsv//swe
650	7	a NATURAL SCIENCESx Computer and Information Sciencesx Computer Sciences0 (SwePub)102012 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
653		a Caucasian
653		a gene expression regulation
653		a genetic variation
653		a genetics
653		a genome-wide association study
653		a human
653		a non insulin dependent diabetes mellitus
653		a physiology
653		a Diabetes Mellitus, Type 2
653		a European Continental Ancestry Group
653		a Gene Expression Regulation
653		a Genetic Variation
653		a Genome-Wide Association Study
653		a Humans
653		a ANDIS
653		a diabetes
653		a diabetics
700	1	a Scott, Laura J.u University of Michigan,Univ Michigan, Dept Biostatist & Ctr Stat Genet, Ann Arbor, MI USA.4 aut
700	1	a Maegi, Reediku University of Tartu,Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.4 aut
700	1	a Marullo, Letiziau University of Ferrara,Univ Ferrara, Dept Life Sci & Biotechnol, Ferrara, Italy.4 aut
700	1	a Gaulton, Kyle J.u University of Oxford,Stanford University,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Stanford Univ, Dept Genet, Stanford, CA USA.4 aut
700	1	a Kaakinen, Marikau Imperial College London,Imperial Coll London, Dept Genom Common Dis, London, England.4 aut
700	1	a Pervjakova, Nataliau Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.4 aut
700	1	a Pers, Tune H.u Broad Inst & Harvard, Program Med & Populat Genet, Cambridge, MA USA.;Boston Childrens Hosp, Div Endocrinol, Ctr Basic & Translat Obes Res, Boston, MA USA.;Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.;Statens Serum Inst, Dept Epidemiol Res, Copenhagen, Denmark.4 aut
700	1	a Johnson, Andrew D.u Natl Heart Lung & Blood Inst, Div Intramural Res, Framingham Heart Study Populat Sci Branch, Framingham, MA USA.4 aut
700	1	a Eicher, John D.u Natl Heart Lung & Blood Inst, Div Intramural Res, Framingham Heart Study Populat Sci Branch, Framingham, MA USA.4 aut
700	1	a Jackson, Anne U.u Univ Michigan, Dept Biostatist & Ctr Stat Genet, Ann Arbor, MI USA.4 aut
700	1	a Ferreira, Teresau Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.4 aut
700	1	a Lee, Yejiu Univ Michigan, Dept Biostatist & Ctr Stat Genet, Ann Arbor, MI USA.4 aut
700	1	a Ma, Clementu Univ Michigan, Dept Biostatist & Ctr Stat Genet, Ann Arbor, MI USA.4 aut
700	1	a Steinthorsdottir, Valgerduru Amgen Inc, DECODE genet, Reykjavik, Iceland.4 aut
700	1	a Thorleifsson, Gudmaru Amgen Inc, DECODE genet, Reykjavik, Iceland.4 aut
700	1	a Qi, Luu Harvard T H Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard T H Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Brigham & Womens Hosp, Channing Div Network Med, Dept Med, Boston, MA USA.;Harvard Med Sch, Boston, MA USA.4 aut
700	1	a Van Zuydam, Natalie R.u Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.4 aut
700	1	a Mahajan, Anubhau Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.4 aut
700	1	a Chen, Hanu Univ Texas Hlth Sci Ctr, Sch Publ Hlth, Human Genet Ctr & Dept Epidemiol, Human Genet Environm Sci, Houston, TX USA.;Univ Texas Hlth Sci Ctr, Sch Biomed Informat, Sch Biomed Informat, Ctr Precis Hlth, Houston, TX USA.4 aut
700	1	a Almgren, Peteru Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - hypertoni,Diabetes - Cardiovascular Disease,Lund University Research Groups,Cardiovascular Research - Hypertension,Lund Univ, Univ Hosp Scania, Dept Clin Sci Malmo, Lund Univ Diabet Ctr, Lund, Sweden.4 aut0 (Swepub:lu)endo-pal
700	1	a Voight, Ben F.u Univ Penn sylvania, Perelman Sch Med, Dept Pharm, Philadelphia, PA USA.;Univ Pennsylvania, Perelman Sch Med, Dept Genet, Philadelphia, PA USA.;Univ Pennsylvania, Perelman Sch Medi cine, Inst Translat Med & Therapeut, Philadelphia, PA USA.4 aut
700	1	a Grallert, Haraldu Res Unit Mol Epidemiol, German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Neuherberg, Germany.;German Ctr Diabet Res, Neuherberg, Germany.4 aut
700	1	a Mueller-Nurasyid, Martinau German Res Ctr Environm Hlth, Inst Genet Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany.;Univ Hosp Grosshadern, Ludwig Maximilians Univ, Dep Med I, Munich, Germany.;Ludwig Maximilians Univ Munchen, Inst Med Informat, Genet Epidemiol, Biometry & Epidemiol, Munich, Germany.;Munich Heart Alliance, German Ctr Cardiovascular Dis, Munich, Germany.4 aut
700	1	a Ried, Janina S.u Karolinska Institutet,German Res Ctr Environm Hlth, Inst Genet Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany.4 aut
700	1	a Rayner, Nigel W.u Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Oxford Ctr Diabet, Endocrinol & Metab, Oxford, England.;Wellcome Trust Sanger Inst, Hinxton, England.4 aut
700	1	a Robertson, Neilu Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Oxford Ctr Diabet, Endocrinol & Metab, Oxford, England.4 aut
700	1	a Karssen, Lennart C.u Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Polyomica S Hertogenbosch, Amsterdam, Netherlands.4 aut
700	1	a Van Leeuwen, Elisabeth M.u Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.4 aut
700	1	a Willems, Sara M.u Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.;Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.4 aut
700	1	a Fuchsberger, Christianu Univ Michigan, Dept Biostatist & Ctr Stat Genet, Ann Arbor, MI USA.4 aut
700	1	a Kwan, Phoenixu Univ Michigan, Dept Biostatist & Ctr Stat Genet, Ann Arbor, MI USA.4 aut
700	1	a Teslovich, Tanya M.u Univ Michigan, Dept Biostatist & Ctr Stat Genet, Ann Arbor, MI USA.4 aut
700	1	a Chanda, Pritamu Johns Hopkins Univ Sch Med, High Throughput Biol Ctr, Baltimore, MD USA.4 aut
700	1	a Li, Manu Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.4 aut
700	1	a Lu, Yingchangu Charles Bronfman Inst Personalized Med, Icahn Sch Med, Mt Sinai, New York, NY USA.;Icahn Sch Med, Genet Obes & Related Metab Traits Program, Mt Sinai, New York, NY USA.4 aut
700	1	a Dina, Christianu Univ Nantes, CNRS, Inst Thorax, Ctr Hosp Univ Nantes, Nantes, France.4 aut
700	1	a Thuillier, Dorotheeu Lille Inst Biol, European Genom Inst Diabet, Lille, France.;Univ Lille, CNRS UMR 8199, European Genom Inst Diabet EGID, Inst Pasteur Lille, Lille, France.4 aut
700	1	a Yengo, Loicu Lille Inst Biol, European Genom Inst Diabet, Lille, France.;Univ Lille, CNRS UMR 8199, European Genom Inst Diabet EGID, Inst Pasteur Lille, Lille, France.4 aut
700	1	a Jiang, Longdau Imperial Coll London, Dept Genom Common Dis, London, England.4 aut
700	1	a Sparso, Thomasu Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.4 aut
700	1	a Kestler, Hans A.u Fritz Lipmann Inst, Leibniz Inst Aging, Jena, Germany.;Univ Ulm, Inst Med Syst Biol, Ulm, Germany.4 aut
700	1	a Chheda, Himanshuu Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland.4 aut
700	1	a Eisele, Lewinu Univ Hosp Essen, Inst Med Informat, Biometry & Epidemiol, Essen, Germany.4 aut
700	1	a Gustafsson, Stefanu Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)stegu732
700	1	a Frånberg, Mattiasu Stockholms universitet,Numerisk analys och datalogi (NADA),Science for Life Laboratory (SciLifeLab),Karolinska Inst, Dept Med Solna, Cardiovascular Med Unit, Stockholm, Sweden.;Sci Life Lab, Stockholm, Sweden.;Stockholm Univ, Dept Numer Anal & Comp Sci, Stockholm, Sweden.4 aut0 (Swepub:su)mafr3971
700	1	a Strawbridge, Rona J.u Karolinska Inst, Dept Med Solna, Cardiovascular Med Unit, Stockholm, Sweden.4 aut
700	1	a Benediktsson, Rafnu Univ Iceland, Fac Med, Reykjavik, Iceland.;Landspitali Univ Hosp, Reykjavik, Iceland.,Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.4 aut
700	1	a Hreidarsson, Astradur B.u Landspitali Univ Hosp, Reykjavik, Iceland.,INSERM, CESP, UMR 1018, Villejuif, France.;Univ Paris Sud, UMR 1018, Villejuif, France.4 aut
700	1	a Kong, Augustineu Amgen Inc, DECODE genet, Reykjavik, Iceland.4 aut
700	1	a Sigurdsson, Gunnaru Landspitali Univ Hosp, Reykjavik, Iceland.;Iceland Heart Assoc, Kopavogur, Iceland.4 aut
700	1	a Kerrison, Nicola D.u Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.4 aut
700	1	a Luan, Jian'anu Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.4 aut
700	1	a Liang, Limingu Karolinska Institutet,Harvard T H Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard T H Chan Sch Publ Hlth, Dept Biostatist, Boston, MA USA.,Natl Human Genome Res Inst, Natl Inst Hlth, Bethesda, MD USA.,Karolinska Inst tutet, Dept Med Epidemiol & Biostatist, Stockholm, Sweden.,Univ N Carolina, Dept Genet, Chapel Hill, NC USA.4 aut
700	1	a Meitinger, Thomasu Munich Heart Alliance, German Ctr Cardiovascular Dis, Munich, Germany.;Fritz Lipmann Inst, Leibniz Inst Aging, Jena, Germany.;Inst Human Genet, Helmholtz Zentrum Munchen, Neuherberg, Germany. Tech Univ Munich, Inst Human Genet, Munich, Germany.4 aut
700	1	a Roden, Michaelu German Ctr Diabet Res, Neuherberg, Germany.;Heinrich Heine Univ, Fac Med, Dept Endocrinol & Diabet, Dusseldorf, Germany.;Heinrich Heine Univ Dusseldorf, Leibniz Inst Diabet Res, German Diabet Ctr, Inst Clin Diabetol, Dusseldorf, Germany.4 aut
700	1	a Thorand, Barbarau German Ctr Diabet Res, Neuherberg, Germany.4 aut
700	1	a Esko, Tonuu Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.;Broad Inst & Harvard, Program Med & Populat Genet, Cambridge, MA USA.;Boston Childrens Hosp, Divis Genet & Endocrinol, Boston, MA USA.;Natl Heart Lung & Blood Inst, Framingham Heart Study, Framingham, MA USA.4 aut
700	1	a Mihailov, Evelinu Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.4 aut
700	1	a Fox, Carolineu Harvard Med Sch, Divis Endocrinol, Diabet & Hypertens, Brigham & Womens Hosp, Boston, MA USA.4 aut
700	1	a Liu, Ching-Tiu Boston Univ Sch Publ Hlth, Dept Biostat, Boston, MA USA.4 aut
700	1	a Rybin, Denisu Boston Univ Sch Publ Hlth, Data Coordinating Ctr, Boston, MA USA.4 aut
700	1	a Isomaa, Bou Folkhalsan Res Ctr, Helsinki, Finland.;Dept Social Serv & Hlth Care, Pietarsaari, Finland.4 aut
700	1	a Lyssenko, Valeriyau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Lund Univ, Univ Hosp Scania, Dept Clin Sci Malmo, Lund Univ Diabet Ctr, Lund, Sweden.4 aut0 (Swepub:lu)endo-vly
700	1	a Tuomi, Tiinamaijau Folkhalsan Res Ctr, Helsinki, Finland.;Univ Helsinki, Helsinki Univ Hosp, Dept Med, Helsinki, Finland.,Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.,Univ Exeter Med Sch, Inst Biomed & Clin Sci, Exeter, Devon, England.,Univ Med Ctr Utrecht, Utrecht, Netherlands.4 aut
700	1	a Couper, David J.u Univ N Carolina, Dept Biostatist, Collaborat Studies Coordinating Ctr, Chapel Hill, NC USA.4 aut
700	1	a Pankow, James S.u Univ Minnesota, Divis Epidemiol Community Hlth, Minneapolis, MN USA.4 aut
700	1	a Grarup, Nielsu Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.4 aut
700	1	a Have, Christian T.4 aut
700	1	a Jorgensen, Marit E.u Steno Diabet Ctr, Gentofte, Denmark.,Univ Lille, CNRS UMR 8199, European Genom Inst Diabet EGID, Inst Pasteur Lille, Lille, France.4 aut
700	1	a Jorgensen, Torbenu Capital Region Denmark, Res Ctr Prevent & Hlth, Copenhagen, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.;Aalborg Univ, Fac Med, Aalborg, Denmark.4 aut
700	1	a Linneberg, Allanu Capital Region Denmark, Res Ctr Prevent & Hlth, Copenhagen, Denmark.;Copenhagen Univ Hosp, Rigshospitalet, Copenhagen, Denmark. Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, DK-1168 Copenhagen, Denmark.4 aut
700	1	a Cornelis, Marilyn C.u NW Univ Feinberg Sch Med, Dept Prevent Med, Chicago, IL USA.,Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Healthy Ageing & Ctr Med Syst Biol, Netherlands Consortium, Netherlands Genom Initiat, Rotterdam, Netherlands.4 aut
700	1	a Van Dam, Rob M.u Harvard T H Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.4 aut
700	1	a Hunter, David J.u Harvard T H Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard T H Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Brigham & Womens Hosp, Channing Div Network Med, Dept Med, Boston, MA USA.;Harvard Med Sch, Boston, MA USA.;Harvard T H Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA USA.4 aut
700	1	a Kraft, Peteru Harvard T H Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard T H Chan Sch Publ Hlth, Dept Biostatist, Boston, MA USA.;Harvard T H Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA USA.4 aut
700	1	a Sun, Qiu Harvard T H Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Brigham & Womens Hosp, Channing Div Network Med, Dept Med, Boston, MA USA.;Harvard Med Sch, Boston, MA USA.4 aut
700	1	a Edkins, Sarahu Wellcome Trust Sanger Inst, Hinxton, England.4 aut
700	1	a Owen, Katharine R.u Univ Oxford, Oxford Ctr Diabet, Endocrinol & Metab, Oxford, England.;Natl Inst Hlth Res Oxford Biomed Res Ctr, Churchill Hosp, Oxford, England.4 aut
700	1	a Perry, John R. B.4 aut
700	1	a Wood, Andrew R.u Univ Exeter Med Sch, Univ Exeter, Genet Complex Traits, Exeter, Devon, England.4 aut
700	1	a Zeggini, Eleftheriau Wellcome Trust Sanger Inst, Hinxton, England.4 aut
700	1	a Tajes-Fernandes, Juanu Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.4 aut
700	1	a Abecasis, Goncalo R.u Univ Michigan, Dept Biostatist & Ctr Stat Genet, Ann Arbor, MI USA.4 aut
700	1	a Lannfelt, Larsu Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)lalan021
700	1	a Chines, Peter S.u Natl Human Genome Res Inst, Natl Inst Hlth, Bethesda, MD USA.4 aut
700	1	a Stringham, Heather M.u Univ Michigan, Dept Biostatist & Ctr Stat Genet, Ann Arbor, MI USA.4 aut
700	1	a Koistinen, Heikki A.u Natl Inst Hlth & Welf, Dept Hlth, Helsinki, Finland.;Univ Helsinki, Helsinki Univ Cent Hosp, Dept Med & Abdominal Ctr, Endocrinol, Helsinki, Finland.;Biomedicum Helsinki 2U, Minerva Fdn Inst Med Res, Helsinki, Finland.4 aut
700	1	a Kinnunen, Leenau Natl Inst Hlth & Welf, Dept Hlth, Helsinki, Finland.;Univ Helsinki, Helsinki Univ Cent Hosp, Dept Med & Abdominal Ctr, Endocrinol, Helsinki, Finland.;Biomedicum Helsinki 2U, Minerva Fdn Inst Med Res, Helsinki, Finland.4 aut
700	1	a Sennblad, Bengtu Karolinska Inst, Dept Med Solna, Cardiovascular Med Unit, Stockholm, Sweden.;Sci Life Lab, Stockholm, Sweden.4 aut
700	1	a Muehleisen, Thomas W.u Univ Bonn, Inst Human Genet, Bonn, Germany.;Univ Bonn, Dept Genom, Life Brain Ctr, Bonn, Germany.4 aut
700	1	a Noethen, Markus M.u Univ Bonn, Inst Human Genet, Bonn, Germany.;Univ Bonn, Dept Genom, Life Brain Ctr, Bonn, Germany.4 aut
700	1	a Pechlivanis, Sonaliu Univ Hosp Essen, Inst Med Informat, Biometry & Epidemiol, Essen, Germany.4 aut
700	1	a Baldassarre, Damianou Ist Ricovero Cura Carattere Sci, Ctr Cardiologico Monzino, Milan, Italy.;Univ Milan, Dipartimento Sci Farmacol Biomol, Milan, Italy.4 aut
700	1	a Gertow, Karlu Karolinska Inst, Dept Med Solna, Cardiovascular Med Unit, Stockholm, Sweden.4 aut
700	1	a Humphries, Steve E.u UCL, Inst Cardiovascular Sci, BHF Labs, Cardiovascular Genet, London, England.4 aut
700	1	a Tremoli, Elenau Ist Ricovero Cura Carattere Sci, Ctr Cardiologico Monzino, Milan, Italy.;Univ Milan, Dipartimento Sci Farmacol Biomol, Milan, Italy.4 aut
700	1	a Klopp, Normanu Res Unit Mol Epidemiol, German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Neuherberg, Germany.;Hannover Med Sch, Hannover Unified Biobank, Hannover, Germany.4 aut
700	1	a Meyer, Juliau German Res Ctr Environm Hlth, Inst Genet Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany.,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Dept Stat, Oxford, England.4 aut
700	1	a Steinbach, Geraldu Univ Ulm, Dept Clin Chem & Cent Lab, Ulm, Germany.4 aut
700	1	a Wennauer, Romanu Erasmus MC, Dept Internal Med, Rotterdam, Netherlands.4 aut
700	1	a Eriksson, Johan G.u Folkhalsan Res Ctr, Helsinki, Finland.;Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.;Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.;Helsinki Univ Cent Hosp, Unit Gen Practice, Helsinki, Finland.4 aut
700	1	a Mannisto, Satuu Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.4 aut
700	1	a Peltonen, Leenau Wellcome Trust Sanger Inst, Hinxton, England.;Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland.;Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.;Broad Inst & Harvard, Cambridge, MA USA.4 aut
700	1	a Tikkanen, Emmiu Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland.;Univ Helsinki, Hjelt Inst, Dept Publ Hlth, Helsinki, Finland.4 aut
700	1	a Charpentier, Guillaumeu Corbeil Essonnes Hosp, Endocrinol Diabetol Unit, Corbeil Essonnes, France.4 aut
700	1	a Eury, Elodie4 aut
700	1	a Lobbens, Stephaneu Univ Lille, CNRS UMR 8199, European Genom Inst Diabet EGID, Inst Pasteur Lille, Lille, France.4 aut
700	1	a Gigante, Brunau Karolinska Institutet,Inst Environm Medi cine, Karolinska Inst, Divis Cardiovascular Epidemiol, Stockholm, Sweden.4 aut
700	1	a Leander, Karinu Karolinska Institutet,Inst Environm Medi cine, Karolinska Inst, Divis Cardiovascular Epidemiol, Stockholm, Sweden.4 aut
700	1	a McLeod, Olgau Karolinska Inst, Dept Med Solna, Cardiovascular Med Unit, Stockholm, Sweden.4 aut
700	1	a Bottinger, Erwin P.u Charles Bronfman Inst Personalized Med, Icahn Sch Med, Mt Sinai, New York, NY USA.4 aut
700	1	a Gottesman, Omriu Charles Bronfman Inst Personalized Med, Icahn Sch Med, Mt Sinai, New York, NY USA.4 aut
700	1	a Ruderfer, Douglasu Icahn Sch Med, Dept Psychiat, Divis Psychiat Genom, Mt Sinai, New York, NY USA.4 aut
700	1	a Blueher, Matthiasu Univ Leipzig, IFB Adiposity Dis, Leipzig, Germany.;Univ Leipzig, Dept Med, Leipzig, Germany.4 aut
700	1	a Kovacs, Peteru Univ Leipzig, IFB Adiposity Dis, Leipzig, Germany.;Univ Leipzig, Dept Med, Leipzig, Germany.4 aut
700	1	a Tonjes, Ankeu Univ Leipzig, IFB Adiposity Dis, Leipzig, Germany.;Univ Leipzig, Dept Med, Leipzig, Germany.4 aut
700	1	a Maruthur, Nisa M.u Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.;Johns Hopkins Bloomberg Sch Med, Dept Med, Divis Gen Internal Med, Baltimore, MD USA.;Johns Hopkins Univ, Welch Ctr Prevent, Epidemiol & Clin Res, Baltimore, MD USA.4 aut
700	1	a Scapoli, Chiarau Univ Ferrara, Dept Life Sci & Biotechnol, Ferrara, Italy.4 aut
700	1	a Erbel, Raimundu Univ Hosp Essen, Inst Med Informat, Biometry & Epidemiol, Essen, Germany.4 aut
700	1	a Joeckel, Karl-Heinzu Univ Hosp Essen, Inst Med Informat, Biometry & Epidemiol, Essen, Germany.4 aut
700	1	a Moebus, Susanneu Univ Hosp Essen, Inst Med Informat, Biometry & Epidemiol, Essen, Germany.4 aut
700	1	a De Faire, Ulfu Karolinska Institutet,Inst Environm Medi cine, Karolinska Inst, Divis Cardiovascular Epidemiol, Stockholm, Sweden.4 aut
700	1	a Hamsten, Andersu Karolinska Institutet,Karolinska Inst, Dept Med Solna, Cardiovascular Med Unit, Stockholm, Sweden.4 aut
700	1	a Stumvoll, Michaelu Univ Leipzig, IFB Adiposity Dis, Leipzig, Germany.;Univ Leipzig, Dept Med, Leipzig, Germany.4 aut
700	1	a Deloukas, Panagiotisu Wellcome Trust Sanger Inst, Hinxton, England.;Queen Mary Univ London, William Harvey Res Inst, Barts & London Sch Med & Dent, London, England.4 aut
700	1	a Donnelly, Peter J.4 aut
700	1	a Frayling, Timothy M.u Univ Exeter Med Sch, Univ Exeter, Genet Complex Traits, Exeter, Devon, England.4 aut
700	1	a Hattersley, Andrew T.4 aut
700	1	a Ripatti, Samuliu Wellcome Trust Sanger Inst, Hinxton, England.;Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland.;Univ Helsinki, Hjelt Inst, Dept Publ Hlth, Helsinki, Finland.;Natl Inst Hlth & Welf, Publ Hlth Genom Unit, Helsinki, Finland.4 aut
700	1	a Salomaa, Veikkou Natl Inst Hlth & Welf, Dept Hlth, Helsinki, Finland.4 aut
700	1	a Lind, Larsu Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)larslind
700	1	a Boehm, Bernhard O.u Univ Med Ctr Ulm, Dept Internal Med, Divis Endocrinol & Diabet, Ulm, Germany.;Nanyang Technol Univ, Imperial Coll London, Lee Kong Chian Sch Med, Singapore, Singapore.4 aut
700	1	a Bergman, Richard N.u Cedars Sinai Med Ctr, Diabetes & Obes Res Inst, Los Angeles, CA USA.4 aut
700	1	a Collins, Francis S.u Natl Human Genome Res Inst, Natl Inst Hlth, Bethesda, MD USA.4 aut
700	1	a Mohlke, Karen L.4 aut
700	1	a Tuomilehto, Jaakkou Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.;Dasman Diabet Inst, Dasman, Kuwait.;Danube Univ Krems, Ctr Vasc Prevent, Krems, Austria.;King Abdulaziz Univ, Diabetes Res Grp, Jeddah, Saudi Arabia.4 aut
700	1	a Hansen, Torbenu Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.;Univ So Denmark, Fac Hlth Sci, Odense, Denmark.4 aut
700	1	a Pedersen, Olufu Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.4 aut
700	1	a Barroso, Inesu Wellcome Trust Sanger Inst, Hinxton, England.;Addenbrookes Hosp Cambridge, Wellcome Trust MRC Inst Metab Sci, Hlth Res Cambridge Biomed Res Ctr, Cambridge, England.;Univ Cambridge Metab Res Labs, Wellcome Trust MRC Inst Metab Sci, Hlth Res Cambridge Biomed Res Ctr, Cambridge, England.4 aut
700	1	a Lannfelt, Lars4 aut
700	1	a Ingelsson, Erik,d 1975-u Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)ering425
700	1	a Lind, Lars4 aut
700	1	a Lindgren, Cecilia M.u Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Broad Inst & Harvard, Cambridge, MA USA.4 aut
700	1	a Cauchi, Stephaneu Lille Inst Biol, European Genom Inst Diabet, Lille, France.4 aut
700	1	a Froguel, Philippeu Imperial Coll London, Dept Genom Common Dis, London, England.;Lille Inst Biol, European Genom Inst Diabet, Lille, France.;Univ Lille, CNRS UMR 8199, European Genom Inst Diabet EGID, Inst Pasteur Lille, Lille, France.4 aut
700	1	a Loos, Ruth J. F.u Charles Bronfman Inst Personalized Med, Icahn Sch Med, Mt Sinai, New York, NY USA.;Icahn Sch Med, Genet Obes & Related Metab Traits Program, Mt Sinai, New York, NY USA.;Mindich Child Hlth & Dev Inst, Icahn Sch Med, Mt Sinai, New York, NY USA.4 aut
700	1	a Balkau, Beverleyu Broad Inst & Harvard, Program Med & Populat Genet, Cambridge, MA USA.;Amgen Inc, DECODE genet, Reykjavik, Iceland.;Harvard Med Sch, Dept Med, Boston, MA USA.;Massachusetts Gen Hosp, Gen Med Divis, Boston, MA USA.,Harvard T H Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard T H Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Brigham & Womens Hosp, Channing Div Network Med, Dept Med, Boston, MA USA.;Harvard Med Sch, Boston, MA USA.4 aut
700	1	a Boeing, Heineru German Inst Human Nutr Potsdam Rehbrucke, Nuthetal, Germany.4 aut
700	1	a Franks, Paul W.u Umeå University,Lunds universitet,Umeå universitet,Medicin,Lund University, Malmö, Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Lund Univ, Malmo, Sweden.;Umea Univ, Umea, Sweden.4 aut0 (Swepub:lu)med-plf
700	1	a Gurrea, Aurelio Barricarteu Navarra Publ Hlth Inst, Pamplona, Spain.;Navarra Inst Hlth Res, Pamplona, Spain.;CIBER Epidemiol & Publ Hlth, Madrid, Spain.4 aut
700	1	a Palli, Domenicou Canc Res & Prevent Inst, Florence, Italy.4 aut
700	1	a Van der Schouw, Yvonne T.4 aut
700	1	a Altshuler, Davidu Broad Inst & Harvard, Cambridge, MA USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA USA.;Harvard Med Sch, Dept Med, Boston, MA USA.;Harvard Med Sch, Dept Genet, Boston, MA USA.;Harvard Med Sch, Dept Mol Biol, Boston, MA USA.;Massachusetts Gen Hosp, Diabet Unit, Boston, MA USA.4 aut
700	1	a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Lund Univ, Univ Hosp Scania, Dept Clin Sci Malmo, Lund Univ Diabet Ctr, Lund, Sweden.;Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland.4 aut0 (Swepub:lu)endo-lgr
700	1	a Langenberg, Claudiau Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.4 aut
700	1	a Wareham, Nicholas J.u Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.4 aut
700	1	a Sijbrands, Ericu Erasmus MC, Dept Internal Med, Rotterdam, Netherlands.4 aut
700	1	a Van Duijn, Cornelia M.4 aut
700	1	a Florez, Jose C.u Broad Inst & Harvard, Program Med & Populat Genet, Cambridge, MA USA.;Harvard Med Sch, Dept Med, Boston, MA USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Diabet Unit, Boston, MA USA.4 aut
700	1	a Meigs, James B.4 aut
700	1	a Boerwinkle, Ericu Univ Texas Hlth Sci Ctr, Human Genet Ctr, Houston, TX USA.;Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX USA.4 aut
700	1	a Gieger, Christianu Res Unit Mol Epidemiol, German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Neuherberg, Germany.;German Res Ctr Environm Hlth, Inst Epidemiol II, Helmholtz Zentrum Munchen, Neuherberg, Germany.4 aut
700	1	a Strauch, Konstantinu German Res Ctr Environm Hlth, Inst Genet Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany.;Ludwig Maximilians Univ Munchen, Inst Med Informat, Genet Epidemiol, Biometry & Epidemiol, Munich, Germany.4 aut
700	1	a Metspalu, Andresu Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.;Univ Tartu, Inst Mol & Cell Biol, Tartu, Estonia.4 aut
700	1	a Morris, Andrew D.u Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland.4 aut
700	1	a Palmer, Colin N. A.u Univ Dundee, Biomed Res Inst, Ninewells Hosp, Cardiovascular & Diabet Med, Dundee, Scotland.4 aut
700	1	a Hu, Frank B.4 aut
700	1	a Thorsteinsdottir, Unnuru Amgen Inc, DECODE genet, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.4 aut
700	1	a Stefansson, Kariu Amgen Inc, DECODE genet, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.4 aut
700	1	a Dupuis, Joseeu Boston Univ Sch Publ Hlth, Dept Biostat, Boston, MA USA.4 aut
700	1	a Morris, Andrew P.u Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England.;Univ Liverpool, Dept Mol & Clin Pharmacol, Liverpool, Merseyside, England.4 aut
700	1	a Boehnke, Michaelu Univ Michigan, Dept Biostatist & Ctr Stat Genet, Ann Arbor, MI USA.4 aut
700	1	a McCarthy, Mark I.u Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Oxford Ctr Diabet, Endocrinol & Metab, Oxford, England.;Natl Inst Hlth Res Oxford Biomed Res Ctr, Churchill Hosp, Oxford, England.4 aut
700	1	a Prokopenko, Ingau Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Imperial Coll London, Dept Genom Common Dis, London, England.;Univ Oxford, Oxford Ctr Diabet, Endocrinol & Metab, Oxford, England.4 aut
710	2	a University of Cambridgeb Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.4 org
773	0	t Diabetesd : American Diabetes Associationg 66:11, s. 2888-2902q 66:11<2888-2902x 0012-1797x 1939-327X
856	4	u https://diabetes.diabetesjournals.org/content/diabetes/66/11/2888.full.pdf
856	4	u http://dx.doi.org/10.2337/db16-1253y FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-148842
856	4 8	u https://doi.org/10.2337/db16-1253
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-141797
856	4 8	u https://lup.lub.lu.se/record/5867f78e-7daa-491d-a64c-af454921c7f1
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:136876541
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-340702

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Av författaren/redakt...: Scott, Robert A.; Scott, Laura J.; Maegi, Reedik; Marullo, Letizia; Gaulton, Kyle J.; Kaakinen, Marika; visa fler...; Pervjakova, Nata ...; Pers, Tune H.; Johnson, Andrew ...; Eicher, John D.; Jackson, Anne U.; Ferreira, Teresa; Lee, Yeji; Ma, Clement; Steinthorsdottir ...; Thorleifsson, Gu ...; Qi, Lu; Van Zuydam, Nata ...; Mahajan, Anubha; Chen, Han; Almgren, Peter; Voight, Ben F.; Grallert, Harald; Mueller-Nurasyid ...; Ried, Janina S.; Rayner, Nigel W.; Robertson, Neil; Karssen, Lennart ...; Van Leeuwen, Eli ...; Willems, Sara M.; Fuchsberger, Chr ...; Kwan, Phoenix; Teslovich, Tanya ...; Chanda, Pritam; Li, Man; Lu, Yingchang; Dina, Christian; Thuillier, Dorot ...; Yengo, Loic; Jiang, Longda; Sparso, Thomas; Kestler, Hans A.; Chheda, Himanshu; Eisele, Lewin; Gustafsson, Stef ...; Frånberg, Mattia ...; Strawbridge, Ron ...; Benediktsson, Ra ...; Hreidarsson, Ast ...; Kong, Augustine; Sigurdsson, Gunn ...; Kerrison, Nicola ...; Luan, Jian'an; Liang, Liming; Meitinger, Thoma ...; Roden, Michael; Thorand, Barbara; Esko, Tonu; Mihailov, Evelin; Fox, Caroline; Liu, Ching-Ti; Rybin, Denis; Isomaa, Bo; Lyssenko, Valeri ...; Tuomi, Tiinamaij ...; Couper, David J.; Pankow, James S.; Grarup, Niels; Have, Christian ...; Jorgensen, Marit ...; Jorgensen, Torbe ...; Linneberg, Allan; Cornelis, Marily ...; Van Dam, Rob M.; Hunter, David J.; Kraft, Peter; Sun, Qi; Edkins, Sarah; Owen, Katharine ...; Perry, John R. B ...; Wood, Andrew R.; Zeggini, Elefthe ...; Tajes-Fernandes, ...; Abecasis, Goncal ...; Lannfelt, Lars; Chines, Peter S.; Stringham, Heath ...; Koistinen, Heikk ...; Kinnunen, Leena; Sennblad, Bengt; Muehleisen, Thom ...; Noethen, Markus ...; Pechlivanis, Son ...; Baldassarre, Dam ...; Gertow, Karl; Humphries, Steve ...; Tremoli, Elena; Klopp, Norman; Meyer, Julia; Steinbach, Geral ...; Wennauer, Roman; Eriksson, Johan ...; Mannisto, Satu; Peltonen, Leena; Tikkanen, Emmi; Charpentier, Gui ...; Eury, Elodie; Lobbens, Stephan ...; Gigante, Bruna; Leander, Karin; McLeod, Olga; Bottinger, Erwin ...; Gottesman, Omri; Ruderfer, Dougla ...; Blueher, Matthia ...; Kovacs, Peter; Tonjes, Anke; Maruthur, Nisa M ...; Scapoli, Chiara; Erbel, Raimund; Joeckel, Karl-He ...; Moebus, Susanne; De Faire, Ulf; Hamsten, Anders; Stumvoll, Michae ...; Deloukas, Panagi ...; Donnelly, Peter ...; Frayling, Timoth ...; Hattersley, Andr ...; Ripatti, Samuli; Salomaa, Veikko; Lind, Lars; Boehm, Bernhard ...; Bergman, Richard ...; Collins, Francis ...; Mohlke, Karen L.; Tuomilehto, Jaak ...; Hansen, Torben; Pedersen, Oluf; Barroso, Ines; Ingelsson, Erik, ...; Lindgren, Cecili ...; Cauchi, Stephane; Froguel, Philipp ...; Loos, Ruth J. F.; Balkau, Beverley; Boeing, Heiner; Franks, Paul W.; Gurrea, Aurelio ...; Palli, Domenico; Van der Schouw, ...; Altshuler, David; Groop, Leif; Langenberg, Clau ...; Wareham, Nichola ...; Sijbrands, Eric; Van Duijn, Corne ...; Florez, Jose C.; Meigs, James B.; Boerwinkle, Eric; Gieger, Christia ...; Strauch, Konstan ...; Metspalu, Andres; Morris, Andrew D ...; Palmer, Colin N. ...; Hu, Frank B.; Thorsteinsdottir ...; Stefansson, Kari; Dupuis, Josee; Morris, Andrew P ...; Boehnke, Michael; McCarthy, Mark I ...; Prokopenko, Inga; visa färre...

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