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Therapeutic efficac...
Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes
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- Carlström, Karl E. (författare)
- Karolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
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- Ewing, Ewoud (författare)
- Karolinska Institutet,Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
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- Granqvist, Mathias (författare)
- Karolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
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- Gyllenberg, Alexandra (författare)
- Karolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
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- Aeinehband, Shahin (författare)
- Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
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- Enoksson, Sara Lind (författare)
- Karolinska Institutet,Department of Clinical Immunology Karolinska University Hospital, Stockholm, Sweden,Karolinska Univ Hosp, Sweden
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- Checa, Antonio (författare)
- Karolinska Institutet,Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
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- Badam, Tejaswi (författare)
- Linköpings universitet,Högskolan i Skövde,Institutionen för biovetenskap,Forskningscentrum för Systembiologi,Department of Physics, Chemistry & Biology (IFM), Bioinformatics, Linköping University, Sweden,Translationell Bioinformatik, Translational Bioinformatics,Bioinformatik,Tekniska fakulteten,Univ Skovde, Sweden
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- Huang, Jesse (författare)
- Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
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- Gomez-Cabrero, David (författare)
- Karolinska Institutet,Translational Bioinformatics Unit, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Publica de Nevarra (UPNA), IdiSNA, Pamplona, Spain,Univ Publ Nevarra UPNA, Spain
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- Gustafsson, Mika (författare)
- Linköpings universitet,Bioinformatik,Tekniska fakulteten
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- Al Nimer, Faiez (författare)
- Karolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
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- Wheelock, Craig E. (författare)
- Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
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- Kockum, Ingrid (författare)
- Karolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
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- Olsson, Tomas (författare)
- Karolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
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- Jagodic, Maja (författare)
- Karolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
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- Piehl, Fredrik (författare)
- Karolinska Institutet,Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
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(creator_code:org_t)
- 2019-07-12
- 2019
- Engelska.
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Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 10:1, s. 1-13
- Relaterad länk:
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https://doi.org/10.1...
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https://his.diva-por... (primary) (Raw object)
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https://www.nature.c...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Dimethyl fumarate (DMF) is a first-line-treatment for relapsing-remitting multiple sclerosis (RRMS). The redox master regulator Nrf2, essential for redox balance, is a target of DMF, but its precise therapeutic mechanisms of action remain elusive. Here we show impact of DMF on circulating monocytes and T cells in a prospective longitudinal RRMS patient cohort. DMF increases the level of oxidized isoprostanes in peripheral blood. Other observed changes, including methylome and transcriptome profiles, occur in monocytes prior to T cells. Importantly, monocyte counts and monocytic ROS increase following DMF and distinguish patients with beneficial treatment-response from non-responders. A single nucleotide polymorphism in the ROS-generating NOX3 gene is associated with beneficial DMF treatment-response. Our data implicate monocyte-derived oxidative processes in autoimmune diseases and their treatment, and identify NOX3 genetic variant, monocyte counts and redox state as parameters potentially useful to inform clinical decisions on DMF therapy of RRMS.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- placebo-controlled phase-3
- TH17 cell-differentiation
- regulatory T-cells
- oxidative stress
- hydrogen-peroxide
- redox regulation
- NRF2 pathway
- oral BG-12
- arthritis
- suppression
- Bioinformatik
- Bioinformatics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Carlström, Karl ...
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Ewing, Ewoud
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Granqvist, Mathi ...
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Gyllenberg, Alex ...
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Aeinehband, Shah ...
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Enoksson, Sara L ...
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visa fler...
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Checa, Antonio
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Badam, Tejaswi
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Huang, Jesse
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Gomez-Cabrero, D ...
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Gustafsson, Mika
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Al Nimer, Faiez
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Wheelock, Craig ...
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Kockum, Ingrid
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Olsson, Tomas
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Jagodic, Maja
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Piehl, Fredrik
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
- Artiklar i publikationen
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Nature Communica ...
- Av lärosätet
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Högskolan i Skövde
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Karolinska Institutet
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Linköpings universitet