Liquid chromatography-ion mobility-high resolution mass spectrometry for analysis of pollutants in indoor dust: Identification and predictive capabilities

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: L773:0003 2670 OR L773:1873 4324 > (2020-2024) > Liquid chromatograp...

Details
MARC

Mullin, L.Waters Corporation, Milford MA, United States (author)

Liquid chromatography-ion mobility-high resolution mass spectrometry for analysis of pollutants in indoor dust : Identification and predictive capabilities

Article/chapterEnglish2020

Publisher, publication year, extent ...

Elsevier,2020
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:oru-83070
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-83070URI
https://doi.org/10.1016/j.aca.2020.05.052DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Dust analysis provides a means to assess the degree of exposure of humans in an indoor environment to various contaminant classes such as flame retardants, pesticides and others. There is increasing interest in non-targeted acquisitions using high resolution mass spectrometry (HRMS) to better capture the contaminant profile. However, these studies are confronted with the challenge of assessing confidence in proposed identifications, particularly when authentic standards are not available. Here, we demonstrate the analysis of dust extracts representing various indoor environments (industrial e-waste processing and domestic) for high-abundance environmental contaminants using a data-independent LC-HRMS approach, incorporating ion mobility spectrometry (IMS) to provide additional characterization capability for the complex samples. Twenty-nine xenobiotic compound identifications were made based on both targeted and non-targeted processing approaches using accurate mass precursor and product ion measurement combined with an ion mobility derived collision-cross section (TWCCSN2) determination. Characterization of the repeatability of TWCCSN2 value measurements and their average relative error to compared authentic standards of 0.38% were consistent with various published studies and represent a robust measurement property. TWCCSN2 values were particularly useful in cases where confirmation after the initial dust analysis was performed using a different chromatographic method, due to the gas-phase measurement being unaffected by such changes. Observed compound TWCCSN2 values were then compared to predicted CCSN2 values obtained using two different machine-learning based predictive techniques. Results from one of the predictive programs indicates a promising avenue for use of these models for supporting compound identification in non-targeted analyses.

Subject headings and genre

NATURVETENSKAP Kemi Analytisk kemi hsv//swe
NATURAL SCIENCES Chemical Sciences Analytical Chemistry hsv//eng
Collisioncross section
Data independent acquisition
High resolution mass spectrometry
Liquid chromatography
Non-targeted screening
Travelling-wave ion mobility
Chromatographic analysis
Dust
Electronic Waste
Flame retardants
Gas chromatography
Ions
Mass spectrometry
Phase measurement
Average relative error
Chromatographic methods
Collision cross sections
Environmental contaminant
Gas-phase measurement
Ion mobility spectrometry
Predictive capabilities
Ion chromatography

Added entries (persons, corporate bodies, meetings, titles ...)

Jobst, K.Memorial University of Newfoundland, St John's NL, Canada (author)
DiLorenzo, R. A.Department of Physiology and Experimental Medicine, The Hospital for Sick Children, Mouse Imaging Centre, Toronto, ON, Canada (author)
Plumb, R.Waters Corporation, Milford MA, United States (author)
Reiner, E. J.University of Toronto, Toronto ON, Canada (author)
Yeung, Leo W. Y.,1981-Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre(Swepub:oru)lyg (author)
Ericson Jogsten, Ingrid,1980-Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre(Swepub:oru)iden (author)
Waters Corporation, Milford MA, United StatesMemorial University of Newfoundland, St John's NL, Canada (creator_code:org_t)

Related titles

In:Analytica Chimica Acta: Elsevier1125, s. 29-400003-26701873-4324

Internet link

Find in a library

Analytica Chimica Acta (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Mullin, L.; Jobst, K.; DiLorenzo, R. A.; Plumb, R.; Reiner, E. J.; Yeung, Leo W. Y. ...; show more...; Ericson Jogsten, ...; show less...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Chemical Science ...; and Analytical Chemi ...

Articles in the publication: Analytica Chimic ...

By the university: Örebro University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se