Glymphatic pathways in the gyrencephalic brain

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Fältnamn	Indikatorer	Metadata
000		03412naa a2200301 4500
001		oai:lup.lub.lu.se:68a913cf-108e-4ba8-9b06-92b64c4b8097
003		SwePub
008		210319s2021 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/68a913cf-108e-4ba8-9b06-92b64c4b80972 URI
024	7	a https://doi.org/10.1177/0271678X219961752 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Bèchet, Nicholas Burdonu Lund University,Lunds universitet,Glia-Immune Interactions,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine4 aut0 (Swepub:lu)ni6106be
245	1 0	a Glymphatic pathways in the gyrencephalic brain
264	1	c 2021
520		a Identification of the perivascular compartment as the point of exchange between cerebrospinal fluid (CSF) and interstitial fluid mediating solute clearance in the brain, named the glymphatic system, has emerged as an important clearance pathway for neurotoxic peptides such as amyloid-beta. However, the foundational science of the glymphatic system is based on rodent studies. Here we investigated whether the glymphatic system exists in a large mammal with a highly gyrified brain. CSF penetration into the brain via perivascular pathways, a hallmark of glymphatic function, was seen throughout the gyrencephalic cortex and subcortical structures, validating the conservation of the glymphatic system in a large mammal. Macroscopic CSF tracer distribution followed the sulci and fissures showing that these folds enhance CSF dispersion. Three-dimensional renditions from light sheet microscopy showed a PVS influx density 4-fold larger in the pig brain than in mice. This demonstrates the existence of an advanced solute transport system in the gyrencephalic brain that could be utilised therapeutically for enhancing waste clearance.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
700	1	a Shanbhag, Nagesh Cu Lund University,Lunds universitet,Glia-Immune Interactions,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine4 aut0 (Swepub:lu)na4682sh
700	1	a Lundgaard, Ibenu Lund University,Lunds universitet,Glia-Immune Interactions,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine4 aut0 (Swepub:lu)ib4521lu
710	2	a Glia-Immune Interactionsb Forskargrupper vid Lunds universitet4 org
773	0	t Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolismx 1559-7016
856	4	u http://dx.doi.org/10.1177/0271678X21996175y FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/68a913cf-108e-4ba8-9b06-92b64c4b8097
856	4 8	u https://doi.org/10.1177/0271678X21996175

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Av författaren/redakt...: Bèchet, Nicholas ...; Shanbhag, Nagesh ...; Lundgaard, Iben

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