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WFRF:(Chen Gary K.)
 

Sökning: WFRF:(Chen Gary K.) > (2020-2024) > Gene–gene interacti...

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FältnamnIndikatorerMetadata
00010689naa a2200913 4500
001oai:DiVA.org:umu-192772
003SwePub
008220309s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1927722 URI
0247 a https://doi.org/10.1186/s40001-022-00638-72 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Rosenberger, Albertu Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany; Institut Für Genetische Epidemiologie, Universitätsmedizin Göttingen, Humboldtallee 32, Göttingen, Germany4 aut
2451 0a Gene–gene interaction of AhR with and within the Wnt cascade affects susceptibility to lung cancer
264 c 2022-01-31
264 1b BioMed Central (BMC),c 2022
338 a electronic2 rdacarrier
520 a Background: Aberrant Wnt signalling, regulating cell development and stemness, influences the development of many cancer types. The Aryl hydrocarbon receptor (AhR) mediates tumorigenesis of environmental pollutants. Complex interaction patterns of genes assigned to AhR/Wnt-signalling were recently associated with lung cancer susceptibility.Aim: To assess the association and predictive ability of AhR/Wnt-genes with lung cancer in cases and controls of European descent.Methods: Odds ratios (OR) were estimated for genomic variants assigned to the Wnt agonist and the antagonistic genes DKK2, DKK3, DKK4, FRZB, SFRP4 and Axin2. Logistic regression models with variable selection were trained, validated and tested to predict lung cancer, at which other previously identified SNPs that have been robustly associated with lung cancer risk could also enter the model. Furthermore, decision trees were created to investigate variant × variant interaction. All analyses were performed for overall lung cancer and for subgroups.Results: No genome-wide significant association of AhR/Wnt-genes with overall lung cancer was observed, but within the subgroups of ever smokers (e.g., maker rs2722278 SFRP4; OR = 1.20; 95% CI 1.13–1.27; p = 5.6 × 10–10) and never smokers (e.g., maker rs1133683 Axin2; OR = 1.27; 95% CI 1.19–1.35; p = 1.0 × 10–12). Although predictability is poor, AhR/Wnt-variants are unexpectedly overrepresented in optimized prediction scores for overall lung cancer and for small cell lung cancer. Remarkably, the score for never-smokers contained solely two AhR/Wnt-variants. The optimal decision tree for never smokers consists of 7 AhR/Wnt-variants and only two lung cancer variants.Conclusions: The role of variants belonging to Wnt/AhR-pathways in lung cancer susceptibility may be underrated in main-effects association analysis. Complex interaction patterns in individuals of European descent have moderate predictive capacity for lung cancer or subgroups thereof, especially in never smokers.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Association
653 a Decision trees
653 a Gene–gene integration
653 a Never smoker
653 a Polygenic risk score
653 a Prediction
653 a Small cell lung cancer
653 a Susceptibility
7001 a Muttray, Nilsu Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany4 aut
7001 a Hung, Rayjean J.u Lunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, ON, Toronto, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada4 aut
7001 a Christiani, David C.u Department of Environmental Health, Harvard T.H. Chan School of Public Health and Massachusetts General Hospital/Harvard Medical School, MA, Boston, United States4 aut
7001 a Caporaso, Neil E.u Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, MD, Bethesda, United States4 aut
7001 a Liu, Geoffreyu Medical Oncology and Medical Biophysics, Princess Margaret Cancer Centre, ON, Toronto, Canada; Medicine and Epidemiology, Dalla Lana School of Public Health, University of Toronto, ON, Toronto, Canada4 aut
7001 a Bojesen, Stig E.u Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen, Denmark4 aut
7001 a Le Marchand, Loicu Epidemiology Program, University of Hawaii Cancer Center, HI, Honolulu, United States4 aut
7001 a Albanes, Demetriosu Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, MD, Bethesda, United States4 aut
7001 a Aldrich, Melinda C.u Department of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center, TN, Nashville, United States4 aut
7001 a Tardon, Adoninau Faculty of Medicine, University of Oviedo, ISPA and CIBERESP, Oviedo, Spain4 aut
7001 a Fernández-Tardón, Guillermou Faculty of Medicine, University of Oviedo, ISPA and CIBERESP, Oviedo, Spain4 aut
7001 a Rennert, Gadu Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel4 aut
7001 a Field, John K.u Department of Molecular and Clinical Cancer Medicine, Roy Castle Lung Cancer Research Programme, The University of Liverpool, Liverpool, United Kingdom4 aut
7001 a Davies, Michael P. A.u Department of Molecular and Clinical Cancer Medicine, Roy Castle Lung Cancer Research Programme, The University of Liverpool, Liverpool, United Kingdom4 aut
7001 a Liloglou, Triantafillosu Department of Molecular and Clinical Cancer Medicine, Roy Castle Lung Cancer Research Programme, The University of Liverpool, Liverpool, United Kingdom4 aut
7001 a Kiemeney, Lambertus A.u Departments of Health Evidence and Urology, Radboud University Medical Center, Nijmegen, Netherlands4 aut
7001 a Lazarus, Philipu Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, WA, Spokane, United States4 aut
7001 a Wendel, Bernadetteu Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany4 aut
7001 a Haugen, Aageu National Institute of Occupational Health, Oslo, Norway4 aut
7001 a Zienolddiny, Shanbehu National Institute of Occupational Health, Oslo, Norway4 aut
7001 a Lam, Stephenu British Columbia Cancer Agency, BC, Vancouver, Canada4 aut
7001 a Schabath, Matthew B.u Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, FL, Tampa, United States4 aut
7001 a Andrew, Angeline S.u Department of Epidemiology, Geisel School of Medicine, NH, Hanover, United States4 aut
7001 a Duell, Eric J.u Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain4 aut
7001 a Arnold, Susanne M.u Markey Cancer Center, University of Kentucky, KY, Lexington, United States4 aut
7001 a Goodman, Gary E.u Swedish Medical Group, WA, Seattle, United States4 aut
7001 a Chen, Chuu Program in Epidemiology, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut
7001 a Doherty, Jennifer A.u Department of Population Health Sciences, Huntsman Cancer Institute, University of Utah, UT, Salt Lake City, United States4 aut
7001 a Taylor, Fionau Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom4 aut
7001 a Cox, Angelau Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom4 aut
7001 a Woll, Penella J.u Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom4 aut
7001 a Risch, Angelau University of Salzburg and Cancer Cluster Salzburg, Salzburg, Austria4 aut
7001 a Muley, Thomas R.u Member of the German Center for Lung Research (DZL), Translational Lung Research Center (TLRC) Heidelberg, Heidelberg, Germany; Translational Research Unit, Thoraxklinik, University Hospital Heidelberg, Heidelberg, Germany4 aut
7001 a Johansson, Mikaelu Umeå universitet,Onkologi4 aut0 (Swepub:umu)mijo0025
7001 a Brennan, Paulu International Agency for Research on Cancer, World Health Organization, Lyon, France4 aut
7001 a Landi, Maria Teresau Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, MD, Bethesda, United States4 aut
7001 a Shete, Sanjay S.u Department of Biostatistics, Division of Basic Sciences, The University of Texas MD Anderson Cancer Center, TX, Houston, United States4 aut
7001 a Amos, Christopher I.u Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States4 aut
7001 a Bickeböller, Heikeu Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany4 aut
7102 a Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany; Institut Für Genetische Epidemiologie, Universitätsmedizin Göttingen, Humboldtallee 32, Göttingen, Germanyb Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany4 org
7730 t European Journal of Medical Researchd : BioMed Central (BMC)g 27:1q 27:1x 0949-2321x 2047-783X
8564 u https://doi.org/10.1186/s40001-022-00638-7y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1643177/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://eurjmedres.biomedcentral.com/track/pdf/10.1186/s40001-022-00638-7
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-192772
8564 8u https://doi.org/10.1186/s40001-022-00638-7

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