WFRF:(Lomnytska Marta)
Sökning: WFRF:(Lomnytska Marta) > Transforming growth...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03577naa a2200445 4500 | |
| 001 | oai:DiVA.org:uu-72987 | |
| 003 | SwePub | |
| 008 | 050531s2004 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-729872 URI |
| 024 | 7 | a https://doi.org/10.1002/pmic.2003006592 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb engb -1 | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Lomnytska, Martau Uppsala universitet,Ludwiginstitutet för cancerforskning4 aut0 (Swepub:uu)marlo829 |
| 245 | 1 0 | a Transforming growth factor-beta1-regulated proteins in human endothelial cells identified by two-dimensional gel electrophoresis and mass spectrometry |
| 264 | 1 | b Wiley,c 2004 |
| 338 | a print2 rdacarrier | |
| 520 | a Transforming growth factor-beta (TGFbeta) is a potent regulator of angiogenesis affecting proliferation, differentiation and migration of endothelial cells. The effect of TGFbeta on endothelial cells depends on the origin of the cells and on the experimental conditions. Global analysis of TGFbeta signalling is expected to unveil mechanisms of this variability and identify novel targets of the growth factor. Here, we report proteome profiling of human microvascular endothelial cells obtained from dermis, which were treated with TGFbeta1 and compared to nontreated cells. We identified 54 proteins affected by TGFbeta1 using two-dimensional gel electrophoresis and peptide mass fingerprinting. Thirteen of the identified proteins are involved in various signalling processes. Seven proteins are involved in cytoskeleton rearrangements and six are involved in regulation of metabolism. Ten proteins were identical to predicted hypothetical proteins with no assigned functions. In agreement with the effect of TGFbeta1 on components of the cytoskeleton, TGFbeta1 induces actin cytoskeleton rearrangements. TGFbeta1 also affected expression of E2F6, p57Kip2, G(q)alpha, hnRNP A1 and myosin light chain proteins as shown by immunoblotting. Down-regulation of the transcriptional repressor E2F6 by TGFbeta1 correlated with a weak growth-inhibitory activity of TGFbeta1 on HMVEC-d cells. Twenty-five of the identified proteins have not previously been described as being regulated by TGFbeta1, providing new insights into TGFbeta1 signalling in endothelial cells. | |
| 520 | a | |
| 653 | a Cells; Cultured | |
| 653 | a Cytoskeleton/*metabolism | |
| 653 | a Dermis | |
| 653 | a Electrophoresis; Gel; Two-Dimensional | |
| 653 | a Endothelial Cells/*metabolism | |
| 653 | a Humans | |
| 653 | a Peptide Mapping | |
| 653 | a Proteome | |
| 653 | a Research Support; Non-U.S. Gov't | |
| 653 | a Signal Transduction/*physiology | |
| 653 | a Transforming Growth Factor beta/*metabolism | |
| 700 | 1 | a Lukiyanchuk, Vasylu Uppsala universitet,Ludwiginstitutet för cancerforskning4 aut0 (Swepub:uu)valuk169 |
| 700 | 1 | a Hellman, Ulfu Uppsala universitet,Ludwiginstitutet för cancerforskning4 aut0 (Swepub:uu)ulfhm |
| 700 | 1 | a Souchelnytskyi, Serhiyu Uppsala universitet,Ludwiginstitutet för cancerforskning4 aut0 (Swepub:uu)sergsouc |
| 710 | 2 | a Uppsala universitetb Ludwiginstitutet för cancerforskning4 org |
| 773 | 0 | t Proteomicsd : Wileyg 4:4, s. 995-1006q 4:4<995-1006x 1615-9853x 1615-9861 |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=15048981&dopt=Citation |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-72987 |
| 856 | 4 8 | u https://doi.org/10.1002/pmic.200300659 |
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