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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005085naa a2200829 4500
001oai:DiVA.org:umu-100946
003SwePub
008150316s2015 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:130660049
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1009462 URI
0247 a https://doi.org/10.1136/annrheumdis-2013-2047492 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1306600492 URI
040 a (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Kim, Kwangwoo4 aut
2451 0a High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci
264 c 2014-02-14
264 1b BMJ,c 2015
338 a print2 rdacarrier
520 a Objective A highly polygenic aetiology and high degree of allele-sharing between ancestries have been well elucidated in genetic studies of rheumatoid arthritis. Recently, the high-density genotyping array Immunochip for immune disease loci identified 14 new rheumatoid arthritis risk loci among individuals of European ancestry. Here, we aimed to identify new rheumatoid arthritis risk loci using Korean-specific Immunochip data. Methods We analysed Korean rheumatoid arthritis case-control samples using the Immunochip and genome-wide association studies (GWAS) array to search for new risk alleles of rheumatoid arthritis with anticitrullinated peptide antibodies. To increase power, we performed a meta-analysis of Korean data with previously published European Immunochip and GWAS data for a total sample size of 9299 Korean and 45 790 European case-control samples. Results We identified eight new rheumatoid arthritis susceptibility loci (TNFSF4, LBH, EOMES, ETS1-FLI1, COG6, RAD51B, UBASH3A and SYNGR1) that passed a genome-wide significance threshold (p<5x10(-8)), with evidence for three independent risk alleles at 1q25/TNFSF4. The risk alleles from the seven new loci except for the TNFSF4 locus (monomorphic in Koreans), together with risk alleles from previously established RA risk loci, exhibited a high correlation of effect sizes between ancestries. Further, we refined the number of single nucleotide polymorphisms (SNPs) that represent potentially causal variants through a trans-ethnic comparison of densely genotyped SNPs. Conclusions This study demonstrates the advantage of dense-mapping and trans-ancestral analysis for identification of potentially causal SNPs. In addition, our findings support the importance of T cells in the pathogenesis and the fact of frequent overlap of risk loci among diverse autoimmune diseases.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
7001 a Bang, So-Young4 aut
7001 a Lee, Hye-Soon4 aut
7001 a Cho, Soo-Kyung4 aut
7001 a Choi, Chan-Bum4 aut
7001 a Sung, Yoon-Kyoung4 aut
7001 a Kim, Tae-Hwan4 aut
7001 a Jun, Jae-Bum4 aut
7001 a Yoo, Dae Hyun4 aut
7001 a Kang, Young Mo4 aut
7001 a Kim, Seong-Kyu4 aut
7001 a Suh, Chang-Hee4 aut
7001 a Shim, Seung-Cheol4 aut
7001 a Lee, Shin-Seok4 aut
7001 a Lee, Jisoo4 aut
7001 a Chung, Won Tae4 aut
7001 a Choe, Jung-Yoon4 aut
7001 a Shin, Hyoung Doo4 aut
7001 a Lee, Jong-Young4 aut
7001 a Han, Bok-Ghee4 aut
7001 a Nath, Swapan K.4 aut
7001 a Eyre, Steve4 aut
7001 a Bowes, John4 aut
7001 a Pappas, Dimitrios A.4 aut
7001 a Kremer, Joel M.4 aut
7001 a Gonzalez-Gay, Miguel A.4 aut
7001 a Rodriguez-Rodriguez, Luis4 aut
7001 a Ärlestig, Lisbethu Umeå universitet,Reumatologi4 aut0 (Swepub:umu)litarg99
7001 a Okada, Yukinori4 aut
7001 a Diogo, Dorothee4 aut
7001 a Liao, Katherine P.u Karolinska Institutet4 aut
7001 a Karlson, Elizabeth W.4 aut
7001 a Raychaudhuri, Soumya4 aut
7001 a Rantapää-Dahlqvist, Solbrittu Umeå universitet,Reumatologi4 aut0 (Swepub:umu)sora0001
7001 a Martin, Javier4 aut
7001 a Klareskog, Larsu Karolinska Institutet4 aut
7001 a Padyukov, Leonid4 aut
7001 a Gregersen, Peter K.4 aut
7001 a Worthington, Jane4 aut
7001 a Greenberg, Jeffrey D.4 aut
7001 a Plenge, Robert M.4 aut
7001 a Bae, Sang-Cheol4 aut
7102 a Umeå universitetb Reumatologi4 org
7730 t Annals of the Rheumatic Diseasesd : BMJg 74:3q 74:3x 0003-4967x 1468-2060
8564 u https://europepmc.org/articles/pmc4467986?pdf=render
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100946
8564 8u https://doi.org/10.1136/annrheumdis-2013-204749
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:130660049

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