SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:prod.swepub.kib.ki.se:134950153"
 

Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:134950153" > Cortical thickness ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003363naa a2200481 4500
001oai:prod.swepub.kib.ki.se:134950153
003SwePub
008240920s2017 | |||||||||||000 ||eng|
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1349501532 URI
0247 a https://doi.org/10.1192/bjp.bp.115.1640202 DOI
040 a (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Fouche, JP4 aut
2451 0a Cortical thickness in obsessive-compulsive disorder: multisite mega-analysis of 780 brain scans from six centres
264 c 2018-01-02
264 1b Royal College of Psychiatrists,c 2017
520 a There is accumulating evidence for the role of fronto-striatal and associated circuits in obsessive–compulsive disorder (OCD) but limited and conflicting data on alterations in cortical thickness.AimsTo investigate alterations in cortical thickness and subcortical volume in OCD.MethodIn total, 412 patients with OCD and 368 healthy adults underwent magnetic resonance imaging scans. Between-group analysis of covariance of cortical thickness and subcortical volumes was performed and regression analyses undertaken.ResultsSignificantly decreased cortical thickness was found in the OCD group compared with controls in the superior and inferior frontal, precentral, posterior cingulate, middle temporal, inferior parietal and precuneus gyri. There was also a group x age interaction in the parietal cortex, with increased thinning with age in the OCD group relative to controls.ConclusionsOur findings are partially consistent with earlier work, suggesting that group differences in grey matter volume and cortical thickness could relate to the same underlying pathology of OCD. They partially support a frontostriatal model of OCD, but also suggest that limbic, temporal and parietal regions play a role in the pathophysiology of the disorder. The group x age interaction effects may be the result of altered neuroplasticity.
7001 a du Plessis, S4 aut
7001 a Hattingh, C4 aut
7001 a Roos, A4 aut
7001 a Lochner, C4 aut
7001 a Soriano-Mas, C4 aut
7001 a Sato, JR4 aut
7001 a Nakamae, T4 aut
7001 a Nishida, S4 aut
7001 a Kwon, JS4 aut
7001 a Jung, WH4 aut
7001 a Mataix-Cols, Du Karolinska Institutet4 aut
7001 a Hoexter, MQ4 aut
7001 a Alonso, P4 aut
7001 a de Wit, SJ4 aut
7001 a Veltman, DJ4 aut
7001 a Stein, DJ4 aut
7001 a van den Heuvel, OA4 aut
7102 a Karolinska Institutet4 org
7730 t The British journal of psychiatry : the journal of mental scienced : Royal College of Psychiatristsg 210:1, s. 67-74q 210:1<67-74x 1472-1465
7730 t British Journal of Psychiatryd : Royal College of Psychiatristsg 210:1, s. 67-74q 210:1<67-74x 0007-1250
8564 u https://www.cambridge.org/core/services/aop-cambridge-core/content/view/E6AE3490306FBA99A1FCDB62583298B6/S0007125000280719a.pdf/div-class-title-cortical-thickness-in-obsessive-compulsive-disorder-multisite-mega-analysis-of-780-brain-scans-from-six-centres-div.pdf
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:134950153
8564 8u https://doi.org/10.1192/bjp.bp.115.164020

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy