Outcome after resection for invasive intraductal papillary mucinous neoplasia is similar to conventional pancreatic ductal adenocarcinoma

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Holmberg, Marcus (författare)

Outcome after resection for invasive intraductal papillary mucinous neoplasia is similar to conventional pancreatic ductal adenocarcinoma

Artikel/kapitelEngelska2021

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Elsevier,2021
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:umu-187092
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-187092URI
https://doi.org/10.1016/j.pan.2021.07.009DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:148474886URI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:ref swepub-contenttype
Ämneskategori:art swepub-publicationtype

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Background/objectives: Resections for intraductal papillary mucinous neoplasm (IPMN) have increased last decades. Overall survival (OS) for conventional pancreatic ductal adenocarcinoma (PDAC) is well known but OS for invasive IPMN (inv-IPMN) is not as conclusive. This study aims to elucidate potential differences in clinicopathology and OS between these tumor types and to investigate if the raised number of resections have affected outcome.Methods: Consecutive patients ≥18 years of age resected for inv-IPMN and PDAC at Karolinska University Hospital between 2009 and 2018 were included. Clinicopathological variables were analyzed in multivariable regression models. Outcome was assessed calculating two-year OS, estimating OS using the Kaplan-Meier model and comparing survival functions with log-rank test.Results: 513 patients were included, 122 with inv-IPMN and 391 with PDAC. During the study period both the proportion resected inv-IPMN and two-year OS, irrespective of tumor type, increased (2.5%–45%; p < 0.001 and 44%–57%; p = 0.005 respectively). In Kaplan-Meier survival analysis inv-IPMN had more favorable median OS (mOS) compared to PDAC (33.6 months vs 19.3 months, p = 0.001). However, in multivariable Cox Regression analysis, tumor type was not a predictor for death, but so were resection period, tumor subtype and N-stage (all p < 0.001).Conclusion: In this large single center observational cohort study, inv-IPMN seemed to have favorable survival outcome compared to PDAC, but after adjusting for predictors for death this benefit vanished. The combination of a pronounced increase in resected inv-IPMN and a concurrent hazard abatement for death within 2 years during the study period proved to be a principal factor.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
Intraductal papillary mucinous neoplasm
Invasive
Pancreatic ductal adenocarcinoma
Survival

Biuppslag (personer, institutioner, konferenser, titlar ...)

Ghorbani, PoyaKarolinska Institutet (författare)
Gilg, StefanKarolinska Institutet (författare)
Del Chiaro, Marco (författare)
Arnelo, UrbanKarolinska Institutet,Umeå universitet,Kirurgi,Department of Clinical Science, Intervention, and Technology, Karolinska Institute, Stockholm, Sweden(Swepub:umu)urar0002 (författare)
Löhr, J.-MatthiasKarolinska Institutet (författare)
Sparrelid, ErnestoKarolinska Institutet (författare)
Karolinska InstitutetKirurgi (creator_code:org_t)

Sammanhörande titlar

Ingår i:Pancreatology (Print): Elsevier21:7, s. 1371-13771424-39031424-3911

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Av författaren/redakt...: Holmberg, Marcus; Ghorbani, Poya; Gilg, Stefan; Del Chiaro, Marc ...; Arnelo, Urban; Löhr, J.-Matthia ...; visa fler...; Sparrelid, Ernes ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kirurgi

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Gastroenterologi

Artiklar i publikationen: Pancreatology (P ...

Av lärosätet: Umeå universitet; Karolinska Institutet

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