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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06104naa a2201453 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:148933572 | |
| 003 | SwePub | |
| 008 | 240701s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1489335722 URI |
| 024 | 7 | a https://doi.org/10.1038/s41398-022-01823-22 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Weeland, CJ4 aut |
| 245 | 1 0 | a The thalamus and its subnuclei-a gateway to obsessive-compulsive disorder |
| 264 | c 2022-02-21 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2022 |
| 520 | a Larger thalamic volume has been found in children with obsessive-compulsive disorder (OCD) and children with clinical-level symptoms within the general population. Particular thalamic subregions may drive these differences. The ENIGMA-OCD working group conducted mega- and meta-analyses to study thalamic subregional volume in OCD across the lifespan. Structural T1-weighted brain magnetic resonance imaging (MRI) scans from 2649 OCD patients and 2774 healthy controls across 29 sites (50 datasets) were processed using the FreeSurfer built-in ThalamicNuclei pipeline to extract five thalamic subregions. Volume measures were harmonized for site effects using ComBat before running separate multiple linear regression models for children, adolescents, and adults to estimate volumetric group differences. All analyses were pre-registered (https://osf.io/73dvy) and adjusted for age, sex and intracranial volume. Unmedicated pediatric OCD patients (<12 years) had larger lateral (d = 0.46), pulvinar (d = 0.33), ventral (d = 0.35) and whole thalamus (d = 0.40) volumes at unadjusted p-values <0.05. Adolescent patients showed no volumetric differences. Adult OCD patients compared with controls had smaller volumes across all subregions (anterior, lateral, pulvinar, medial, and ventral) and smaller whole thalamic volume (d = −0.15 to −0.07) after multiple comparisons correction, mostly driven by medicated patients and associated with symptom severity. The anterior thalamus was also significantly smaller in patients after adjusting for thalamus size. Our results suggest that OCD-related thalamic volume differences are global and not driven by particular subregions and that the direction of effects are driven by both age and medication status. | |
| 700 | 1 | a Kasprzak, S4 aut |
| 700 | 1 | a de Joode, NT4 aut |
| 700 | 1 | a Abe, Y4 aut |
| 700 | 1 | a Alonso, P4 aut |
| 700 | 1 | a Ameis, SH4 aut |
| 700 | 1 | a Anticevic, A4 aut |
| 700 | 1 | a Arnold, PD4 aut |
| 700 | 1 | a Balachander, S4 aut |
| 700 | 1 | a Banaj, N4 aut |
| 700 | 1 | a Bargallo, N4 aut |
| 700 | 1 | a Batistuzzo, MC4 aut |
| 700 | 1 | a Benedetti, F4 aut |
| 700 | 1 | a Beucke, JCu Karolinska Institutet4 aut |
| 700 | 1 | a Bollettini, I4 aut |
| 700 | 1 | a Brecke, V4 aut |
| 700 | 1 | a Brem, S4 aut |
| 700 | 1 | a Cappi, C4 aut |
| 700 | 1 | a Cheng, YQ4 aut |
| 700 | 1 | a Cho, KIK4 aut |
| 700 | 1 | a Costa, DLC4 aut |
| 700 | 1 | a Dallaspezia, S4 aut |
| 700 | 1 | a Denys, D4 aut |
| 700 | 1 | a Eng, GK4 aut |
| 700 | 1 | a Ferreira, S4 aut |
| 700 | 1 | a Feusner, JD4 aut |
| 700 | 1 | a Fontaine, M4 aut |
| 700 | 1 | a Fouche, JP4 aut |
| 700 | 1 | a Grazioplene, RG4 aut |
| 700 | 1 | a Gruner, P4 aut |
| 700 | 1 | a He, MX4 aut |
| 700 | 1 | a Hirano, Y4 aut |
| 700 | 1 | a Hoexter, MQ4 aut |
| 700 | 1 | a Huyser, C4 aut |
| 700 | 1 | a Hu, H4 aut |
| 700 | 1 | a Jaspers-Fayer, F4 aut |
| 700 | 1 | a Kathmann, N4 aut |
| 700 | 1 | a Kaufmann, C4 aut |
| 700 | 1 | a Kim, M4 aut |
| 700 | 1 | a Koch, K4 aut |
| 700 | 1 | a Bin Kwak, Y4 aut |
| 700 | 1 | a Kwon, JS4 aut |
| 700 | 1 | a Lazaro, L4 aut |
| 700 | 1 | a Li, CSR4 aut |
| 700 | 1 | a Lochner, C4 aut |
| 700 | 1 | a Marsh, R4 aut |
| 700 | 1 | a Martinez-Zalacain, I4 aut |
| 700 | 1 | a Mataix-Cols, Du Karolinska Institutet4 aut |
| 700 | 1 | a Menchon, JM4 aut |
| 700 | 1 | a Minnuzi, L4 aut |
| 700 | 1 | a Moreira, PS4 aut |
| 700 | 1 | a Morgado, P4 aut |
| 700 | 1 | a Nakagawa, A4 aut |
| 700 | 1 | a Nakamae, T4 aut |
| 700 | 1 | a Narayanaswamy, JC4 aut |
| 700 | 1 | a Nurmi, EL4 aut |
| 700 | 1 | a Ortiz, AE4 aut |
| 700 | 1 | a Pariente, JC4 aut |
| 700 | 1 | a Piacentini, J4 aut |
| 700 | 1 | a Pico-Perez, M4 aut |
| 700 | 1 | a Piras, F4 aut |
| 700 | 1 | a Piras, F4 aut |
| 700 | 1 | a Pittenger, C4 aut |
| 700 | 1 | a Reddy, YCJ4 aut |
| 700 | 1 | a Rodriguez-Manrique, D4 aut |
| 700 | 1 | a Sakai, Y4 aut |
| 700 | 1 | a Shimizu, E4 aut |
| 700 | 1 | a Shivakumar, V4 aut |
| 700 | 1 | a Simpson, HB4 aut |
| 700 | 1 | a Soreni, N4 aut |
| 700 | 1 | a Soriano-Mas, C4 aut |
| 700 | 1 | a Sousa, N4 aut |
| 700 | 1 | a Spalletta, G4 aut |
| 700 | 1 | a Stern, ER4 aut |
| 700 | 1 | a Stevens, MC4 aut |
| 700 | 1 | a Stewart, SE4 aut |
| 700 | 1 | a Szeszko, PR4 aut |
| 700 | 1 | a Takahashi, J4 aut |
| 700 | 1 | a Tanamatis, T4 aut |
| 700 | 1 | a Tang, JS4 aut |
| 700 | 1 | a Thorsen, AL4 aut |
| 700 | 1 | a Tolin, D4 aut |
| 700 | 1 | a van der Werf, YD4 aut |
| 700 | 1 | a van Marle, H4 aut |
| 700 | 1 | a van Wingen, GA4 aut |
| 700 | 1 | a Vecchio, D4 aut |
| 700 | 1 | a Venkatasubramanian, G4 aut |
| 700 | 1 | a Walitza, S4 aut |
| 700 | 1 | a Wang, JC4 aut |
| 700 | 1 | a Wang, Z4 aut |
| 700 | 1 | a Watanabe, A4 aut |
| 700 | 1 | a Wolters, LH4 aut |
| 700 | 1 | a Xu, XF4 aut |
| 700 | 1 | a Yun, JY4 aut |
| 700 | 1 | a Zhao, Q4 aut |
| 700 | 1 | a White, T4 aut |
| 700 | 1 | a Thompson, PM4 aut |
| 700 | 1 | a Stein, DJ4 aut |
| 700 | 1 | a van den Heuvel, OA4 aut |
| 700 | 1 | a Vriend, C4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Translational psychiatryd : Springer Science and Business Media LLCg 12:1, s. 70-q 12:1<70-x 2158-3188 |
| 856 | 4 | u https://www.nature.com/articles/s41398-022-01823-2.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:148933572 |
| 856 | 4 8 | u https://doi.org/10.1038/s41398-022-01823-2 |
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- Weeland, CJ
- Kasprzak, S
- de Joode, NT
- Abe, Y
- Alonso, P
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- Anticevic, A
- Arnold, PD
- Balachander, S
- Banaj, N
- Bargallo, N
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- Bollettini, I
- Brecke, V
- Brem, S
- Cappi, C
- Cheng, YQ
- Cho, KIK
- Costa, DLC
- Dallaspezia, S
- Denys, D
- Eng, GK
- Ferreira, S
- Feusner, JD
- Fontaine, M
- Fouche, JP
- Grazioplene, RG
- Gruner, P
- He, MX
- Hirano, Y
- Hoexter, MQ
- Huyser, C
- Hu, H
- Jaspers-Fayer, F
- Kathmann, N
- Kaufmann, C
- Kim, M
- Koch, K
- Bin Kwak, Y
- Kwon, JS
- Lazaro, L
- Li, CSR
- Lochner, C
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- Mataix-Cols, D
- Menchon, JM
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- Moreira, PS
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