Sökning: WFRF:(Borecki Ingrid B) > Genome-wide meta-an...
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000 | 14095naa a2202641 4500 | |
001 | oai:DiVA.org:uu-275673 | |
003 | SwePub | |
008 | 160204s2016 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-118403 | |
009 | oai:lup.lub.lu.se:a43cac51-7d1c-4b8b-bea1-43549c501499 | |
009 | oai:gup.ub.gu.se/243492 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2756732 URI |
024 | 7 | a https://doi.org/10.1038/ncomms104942 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1184032 URI |
024 | 7 | a https://lup.lub.lu.se/record/88298032 URI |
024 | 7 | a https://gup.ub.gu.se/publication/2434922 URI |
040 | a (SwePub)uud (SwePub)umud (SwePub)lud (SwePub)gu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Kilpeläinen, Tuomas O4 aut |
245 | 1 0 | a Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels |
264 | c 2016-02-01 | |
264 | 1 | b Springer Science and Business Media LLC,c 2016 |
338 | a electronic2 rdacarrier | |
520 | a Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe obesity, no common loci regulating circulating leptin levels have been uncovered. Therefore, we performed a genome-wide association study (GWAS) of circulating leptin levels from 32,161 individuals and followed up loci reaching P<10(-6) in 19,979 additional individuals. We identify five loci robustly associated (P<5 × 10(-8)) with leptin levels in/near LEP, SLC32A1, GCKR, CCNL1 and FTO. Although the association of the FTO obesity locus with leptin levels is abolished by adjustment for BMI, associations of the four other loci are independent of adiposity. The GCKR locus was found associated with multiple metabolic traits in previous GWAS and the CCNL1 locus with birth weight. Knockdown experiments in mouse adipose tissue explants show convincing evidence for adipogenin, a regulator of adipocyte differentiation, as the novel causal gene in the SLC32A1 locus influencing leptin levels. Our findings provide novel insights into the regulation of leptin production by adipose tissue and open new avenues for examining the influence of variation in leptin levels on adiposity and metabolic health. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng |
653 | a adipose tissue; animal tissue; Article; birth weight; body mass; controlled study; explant; female; follow up; gene locus; genetic association; genetic trait; human; major clinical study; male; meta analysis (topic); mouse; nonhuman; obesity | |
700 | 1 | a Carli, Jayne F Martin4 aut |
700 | 1 | a Skowronski, Alicja A4 aut |
700 | 1 | a Sun, Qi4 aut |
700 | 1 | a Kriebel, Jennifer4 aut |
700 | 1 | a Feitosa, Mary F4 aut |
700 | 1 | a Hedman, Åsa Ku Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)ashed124 |
700 | 1 | a Drong, Alexander W4 aut |
700 | 1 | a Hayes, James E4 aut |
700 | 1 | a Zhao, Jinghua4 aut |
700 | 1 | a Pers, Tune H4 aut |
700 | 1 | a Schick, Ursula4 aut |
700 | 1 | a Grarup, Niels4 aut |
700 | 1 | a Kutalik, Zoltán4 aut |
700 | 1 | a Trompet, Stella4 aut |
700 | 1 | a Mangino, Massimo4 aut |
700 | 1 | a Kristiansson, Kati4 aut |
700 | 1 | a Beekman, Marian4 aut |
700 | 1 | a Lyytikäinen, Leo-Pekka4 aut |
700 | 1 | a Eriksson, Joelu Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research4 aut0 (Swepub:gu)xerjoe |
700 | 1 | a Henneman, Peter4 aut |
700 | 1 | a Lahti, Jari4 aut |
700 | 1 | a Tanaka, Toshiko4 aut |
700 | 1 | a Luan, Jian'an4 aut |
700 | 1 | a Greco M, Fabiola Del4 aut |
700 | 1 | a Pasko, Dorota4 aut |
700 | 1 | a Renström, Fridau Umeå University,Lund University,Lunds universitet,Umeå universitet,Enheten för biobanksforskning,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö 20502, Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-frm |
700 | 1 | a Willems, Sara M4 aut |
700 | 1 | a Mahajan, Anubha4 aut |
700 | 1 | a Rose, Lynda M4 aut |
700 | 1 | a Guo, Xiuqing4 aut |
700 | 1 | a Liu, Yongmei4 aut |
700 | 1 | a Kleber, Marcus E4 aut |
700 | 1 | a Pérusse, Louis4 aut |
700 | 1 | a Gaunt, Tom4 aut |
700 | 1 | a Söderberg, Stefanu Umeå universitet,Kardiologi4 aut0 (Swepub:umu)stso0001 |
700 | 1 | a Ju Sung, Yun4 aut |
700 | 1 | a Ramos, Yolande F4 aut |
700 | 1 | a Amin, Najaf4 aut |
700 | 1 | a Amuzu, Antoinette4 aut |
700 | 1 | a Barroso, Inês4 aut |
700 | 1 | a Bellis, Claire4 aut |
700 | 1 | a Blangero, John4 aut |
700 | 1 | a Buckley, Brendan M4 aut |
700 | 1 | a Böhringer, Stefan4 aut |
700 | 1 | a I Chen, Yii-Der4 aut |
700 | 1 | a de Craen, Anton J N4 aut |
700 | 1 | a Crosslin, David R4 aut |
700 | 1 | a Dale, Caroline E4 aut |
700 | 1 | a Dastani, Zari4 aut |
700 | 1 | a Day, Felix R4 aut |
700 | 1 | a Deelen, Joris4 aut |
700 | 1 | a Delgado, Graciela E4 aut |
700 | 1 | a Demirkan, Ayse4 aut |
700 | 1 | a Finucane, Francis M4 aut |
700 | 1 | a Ford, Ian4 aut |
700 | 1 | a Garcia, Melissa E4 aut |
700 | 1 | a Gieger, Christian4 aut |
700 | 1 | a Gustafsson, Stefanu Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)stegu732 |
700 | 1 | a Hallmans, Göranu Umeå universitet,Näringsforskning,Enheten för biobanksforskning4 aut |
700 | 1 | a Hankinson, Susan E4 aut |
700 | 1 | a Havulinna, Aki S4 aut |
700 | 1 | a Herder, Christian4 aut |
700 | 1 | a Hernandez, Dena4 aut |
700 | 1 | a Hicks, Andrew A4 aut |
700 | 1 | a Hunter, David J4 aut |
700 | 1 | a Illig, Thomas4 aut |
700 | 1 | a Ingelsson, Eriku Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)ering425 |
700 | 1 | a Ioan-Facsinay, Andreea4 aut |
700 | 1 | a Jansson, John-Olov,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xjanjo |
700 | 1 | a Jenny, Nancy S4 aut |
700 | 1 | a Jørgensen, Marit E4 aut |
700 | 1 | a Jørgensen, Torben4 aut |
700 | 1 | a Karlsson, Magnusu Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)orto-mka |
700 | 1 | a Koenig, Wolfgang4 aut |
700 | 1 | a Kraft, Peter4 aut |
700 | 1 | a Kwekkeboom, Joanneke4 aut |
700 | 1 | a Laatikainen, Tiina4 aut |
700 | 1 | a Ladwig, Karl-Heinz4 aut |
700 | 1 | a LeDuc, Charles A4 aut |
700 | 1 | a Lowe, Gordon4 aut |
700 | 1 | a Lu, Yingchang4 aut |
700 | 1 | a Marques-Vidal, Pedro4 aut |
700 | 1 | a Meisinger, Christa4 aut |
700 | 1 | a Menni, Cristina4 aut |
700 | 1 | a Morris, Andrew P4 aut |
700 | 1 | a Myers, Richard H4 aut |
700 | 1 | a Männistö, Satu4 aut |
700 | 1 | a Nalls, Mike A4 aut |
700 | 1 | a Paternoster, Lavinia4 aut |
700 | 1 | a Peters, Annette4 aut |
700 | 1 | a Pradhan, Aruna D4 aut |
700 | 1 | a Rankinen, Tuomo4 aut |
700 | 1 | a Rasmussen-Torvik, Laura J4 aut |
700 | 1 | a Rathmann, Wolfgang4 aut |
700 | 1 | a Rice, Treva K4 aut |
700 | 1 | a Brent Richards, J4 aut |
700 | 1 | a Ridker, Paul M4 aut |
700 | 1 | a Sattar, Naveed4 aut |
700 | 1 | a Savage, David B4 aut |
700 | 1 | a Söderberg, Stefan4 aut |
700 | 1 | a Timpson, Nicholas J4 aut |
700 | 1 | a Vandenput, Liesbeth,d 1974u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xvanli |
700 | 1 | a van Heemst, Diana4 aut |
700 | 1 | a Uh, Hae-Won4 aut |
700 | 1 | a Vohl, Marie-Claude4 aut |
700 | 1 | a Walker, Mark4 aut |
700 | 1 | a Wichmann, Heinz-Erich4 aut |
700 | 1 | a Widén, Elisabeth4 aut |
700 | 1 | a Wood, Andrew R4 aut |
700 | 1 | a Yao, Jie4 aut |
700 | 1 | a Zeller, Tanja4 aut |
700 | 1 | a Zhang, Yiying4 aut |
700 | 1 | a Meulenbelt, Ingrid4 aut |
700 | 1 | a Kloppenburg, Margreet4 aut |
700 | 1 | a Astrup, Arne4 aut |
700 | 1 | a Sørensen, Thorkild I A4 aut |
700 | 1 | a Sarzynski, Mark A4 aut |
700 | 1 | a Rao, D C4 aut |
700 | 1 | a Jousilahti, Pekka4 aut |
700 | 1 | a Vartiainen, Erkki4 aut |
700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a Rivadeneira, Fernando4 aut |
700 | 1 | a Uitterlinden, André G4 aut |
700 | 1 | a Kajantie, Eero4 aut |
700 | 1 | a Osmond, Clive4 aut |
700 | 1 | a Palotie, Aarno4 aut |
700 | 1 | a Eriksson, Johan G4 aut |
700 | 1 | a Heliövaara, Markku4 aut |
700 | 1 | a Knekt, Paul B4 aut |
700 | 1 | a Koskinen, Seppo4 aut |
700 | 1 | a Jula, Antti4 aut |
700 | 1 | a Perola, Markus4 aut |
700 | 1 | a Huupponen, Risto K4 aut |
700 | 1 | a Viikari, Jorma S4 aut |
700 | 1 | a Kähönen, Mika4 aut |
700 | 1 | a Lehtimäki, Terho4 aut |
700 | 1 | a Raitakari, Olli T4 aut |
700 | 1 | a Mellström, Dan,d 1945u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xmelda |
700 | 1 | a Lorentzon, Mattias,d 1970u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xlomat |
700 | 1 | a Casas, Juan P4 aut |
700 | 1 | a Bandinelli, Stefanie4 aut |
700 | 1 | a März, Winfried4 aut |
700 | 1 | a Isaacs, Aaron4 aut |
700 | 1 | a van Dijk, Ko W4 aut |
700 | 1 | a van Duijn, Cornelia M4 aut |
700 | 1 | a Harris, Tamara B4 aut |
700 | 1 | a Bouchard, Claude4 aut |
700 | 1 | a Allison, Matthew A4 aut |
700 | 1 | a Chasman, Daniel I4 aut |
700 | 1 | a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xohlcl |
700 | 1 | a Lind, Larsu Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)larslind |
700 | 1 | a Scott, Robert A4 aut |
700 | 1 | a Langenberg, Claudia4 aut |
700 | 1 | a Wareham, Nicholas J4 aut |
700 | 1 | a Ferrucci, Luigi4 aut |
700 | 1 | a Frayling, Timothy M4 aut |
700 | 1 | a Pramstaller, Peter P4 aut |
700 | 1 | a Borecki, Ingrid B4 aut |
700 | 1 | a Waterworth, Dawn M4 aut |
700 | 1 | a Bergmann, Sven4 aut |
700 | 1 | a Waeber, Gérard4 aut |
700 | 1 | a Vollenweider, Peter4 aut |
700 | 1 | a Vestergaard, Henrik4 aut |
700 | 1 | a Hansen, Torben4 aut |
700 | 1 | a Pedersen, Oluf4 aut |
700 | 1 | a Hu, Frank B4 aut |
700 | 1 | a Eline Slagboom, P4 aut |
700 | 1 | a Grallert, Harald4 aut |
700 | 1 | a Spector, Tim D4 aut |
700 | 1 | a Jukema, J W4 aut |
700 | 1 | a Klein, Robert J4 aut |
700 | 1 | a Schadt, Erik E4 aut |
700 | 1 | a Franks, Paul W.u Umeå University,Lund University,Lunds universitet,Umeå universitet,Medicin,Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachussetts 02115, USA; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö 20502, Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-plf |
700 | 1 | a Lindgren, Cecilia M4 aut |
700 | 1 | a Leibel, Rudolph L4 aut |
700 | 1 | a Loos, Ruth J F4 aut |
710 | 2 | a Uppsala universitetb Molekylär epidemiologi4 org |
773 | 0 | t Nature Communicationsd : Springer Science and Business Media LLCg 7q 7x 2041-1723 |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:900718/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://www.nature.com/articles/ncomms10494.pdf |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:918918/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://dx.doi.org/10.1038/ncomms10494x freey FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-275673 |
856 | 4 8 | u https://doi.org/10.1038/ncomms10494 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-118403 |
856 | 4 8 | u https://lup.lub.lu.se/record/8829803 |
856 | 4 8 | u https://gup.ub.gu.se/publication/243492 |
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