WFRF:(Howells F. M.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 15983naa a2201249 4500 | |
| 001 | oai:DiVA.org:liu-174557 | |
| 003 | SwePub | |
| 008 | 210322s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1745572 URI |
| 024 | 7 | a https://doi.org/10.1017/S10928529200010912 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Fountoulakis, K.N.u Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece4 aut |
| 245 | 1 0 | a Modeling psychological function in patients with schizophrenia with the PANSS :b An international multi-center study |
| 264 | 1 | b Cambridge University Press,c 2021 |
| 338 | a print2 rdacarrier | |
| 520 | a Background.The aim of the current study was to explore the changing interrelationships among clinical variables through the stages of schizophrenia in order to assemble a comprehensive and meaningful disease model.Methods.Twenty-nine centers from 25 countries participated and included 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Multiple linear regression analysis and visual inspection of plots were performed.Results.The results suggest that with progression stages, there are changing correlations among Positive and Negative Syndrome Scale factors at each stage and each factor correlates with all the others in that particular stage, in which this factor is dominant. This internal structure further supports the validity of an already proposed four stages model, with positive symptoms dominating the first stage, excitement/hostility the second, depression the third, and neurocognitive decline the last stage.Conclusions.The current study investigated the mental organization and functioning in patients with schizophrenia in relation to different stages of illness progression. It revealed two distinct “cores” of schizophrenia, the “Positive” and the “Negative,” while neurocognitive decline escalates during the later stages. Future research should focus on the therapeutic implications of such a model. Stopping the progress of the illness could demand to stop the succession of stages. This could be achieved not only by both halting the triggering effect of positive and negative symptoms, but also by stopping the sensitization effect on the neural pathways responsible for the development of hostility, excitement, anxiety, and depression as well as the deleterious effect on neural networks responsible for neurocognition. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
| 653 | a long-term course; model; outcome; Schizophrenia; staging | |
| 700 | 1 | a Dragioti, Elena,c Ph.D.u Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Stockholm Psychiatric Southwest Clinic, Karolinska Huddinge University Hospital, Sweden4 aut0 (Swepub:liu)eledr71 |
| 700 | 1 | a Theofilidis, A.T.u 3rd Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece4 aut |
| 700 | 1 | a Wiklund, Tobias,d 1986-u Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Stockholm Psychiatric Southwest Clinic, Karolinska Huddinge University Hospital, Huddinge, Sweden4 aut0 (Swepub:liu)tobwi28 |
| 700 | 1 | a Atmatzidis, Xenofonu Linköpings universitet,Institutionen för hälsa, medicin och vård,Medicinska fakulteten,Stockholm Psychiatric Southwest Clinic, Karolinska Huddinge University Hospital, Huddinge, Sweden4 aut0 (Swepub:liu)n/a |
| 700 | 1 | a Nimatoudis, I.u 3rd Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece4 aut |
| 700 | 1 | a Thys, E.u University Psychiatric Center, Katholieke Universiteit Leuven, Kortenberg, Belgium4 aut |
| 700 | 1 | a Wampers, M.u University Psychiatric Center, Katholieke Universiteit Leuven, Kortenberg, Belgium; Department of Neurosciences, Katholieke Universiteit Leuven, Leuven, Belgium4 aut |
| 700 | 1 | a Hranov, L.u University Multiprofile Hospital for Active Treatment in Neurology and Psychiatry sveti Naum, Sofia, Bulgaria4 aut |
| 700 | 1 | a Hristova, T.u University Multiprofile Hospital for Active Treatment in Neurology and Psychiatry sveti Naum, Sofia, Bulgaria4 aut |
| 700 | 1 | a Aptalidis, D.u University Multiprofile Hospital for Active Treatment in Neurology and Psychiatry sveti Naum, Sofia, Bulgaria4 aut |
| 700 | 1 | a Milev, R.u Department of Psychiatry, Queens University, Providence Care Hospital, Kingston, ON, Canada4 aut |
| 700 | 1 | a Iftene, F.u Department of Psychiatry, Queens University, Providence Care Hospital, Kingston, ON, Canada4 aut |
| 700 | 1 | a Spaniel, F.u National Institute of Mental Health, Klecany, Czech Republic4 aut |
| 700 | 1 | a Knytl, P.u National Institute of Mental Health, Klecany, Czech Republic4 aut |
| 700 | 1 | a Furstova, P.u National Institute of Mental Health, Klecany, Czech Republic4 aut |
| 700 | 1 | a From, T.u Department of Psychiatry, University of Turku, Turku, Finland4 aut |
| 700 | 1 | a Karlsson, H.u Department of Psychiatry, University of Turku, Turku, Finland4 aut |
| 700 | 1 | a Walta, M.u Department of Psychiatry, University of Turku, Turku, Finland4 aut |
| 700 | 1 | a Salokangas, R.K.R.u Department of Psychiatry, University of Turku, Turku, Finland4 aut |
| 700 | 1 | a Azorin, J.-M.u Department of Psychiatry, Sainte Marguerite University Hospital, Marseille, France; Timone Institute of Neuroscience, Marseille, France4 aut |
| 700 | 1 | a Bouniard, J.u Department of Psychiatry, Sainte Marguerite University Hospital, Marseille, France; Timone Institute of Neuroscience, Marseille, France4 aut |
| 700 | 1 | a Montant, J.u Department of Psychiatry, Sainte Marguerite University Hospital, Marseille, France; Timone Institute of Neuroscience, Marseille, France4 aut |
| 700 | 1 | a Juckel, G.u Department of Psychiatry, Ruhr University Bochum, Bochum, Germany4 aut |
| 700 | 1 | a Haussleiter, I.S.u Department of Psychiatry, Ruhr University Bochum, Bochum, Germany4 aut |
| 700 | 1 | a Douzenis, A.u 2nd Department of Psychiatry, National and Kapodistrian University of Athens, Athens, Greece4 aut |
| 700 | 1 | a Michopoulos, I.u 2nd Department of Psychiatry, National and Kapodistrian University of Athens, Athens, Greece4 aut |
| 700 | 1 | a Ferentinos, P.u 2nd Department of Psychiatry, National and Kapodistrian University of Athens, Athens, Greece4 aut |
| 700 | 1 | a Smyrnis, N.u Department of Psychiatry, National and Kapodistrian University of Athens School of Medicine, Eginition Hospital, Athens, Greece4 aut |
| 700 | 1 | a Mantonakis, L.u Department of Psychiatry, National and Kapodistrian University of Athens School of Medicine, Eginition Hospital, Athens, Greece4 aut |
| 700 | 1 | a Nemes, Z.u Nyír Gyula Hospital, Budapest, Hungary4 aut |
| 700 | 1 | a Gonda, X.u Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary4 aut |
| 700 | 1 | a Vajda, D.u Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary4 aut |
| 700 | 1 | a Juhasz, A.u Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary4 aut |
| 700 | 1 | a Shrivastava, A.u Western University, London, ON, Canada4 aut |
| 700 | 1 | a Waddington, J.u Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland4 aut |
| 700 | 1 | a Pompili, M.u Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, SantAndrea Hospital, Sapienza University of Rome, Rome, Italy4 aut |
| 700 | 1 | a Comparelli, A.u Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, SantAndrea Hospital, Sapienza University of Rome, Rome, Italy4 aut |
| 700 | 1 | a Corigliano, V.u Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, SantAndrea Hospital, Sapienza University of Rome, Rome, Italy4 aut |
| 700 | 1 | a Rancans, E.u Department of Psychiatry and Narcology, Riga Stradins University, Riga, Latvia4 aut |
| 700 | 1 | a Navickas, A.u Department of Clinic of Psychiatric, Faculty of Medicine, Vilnius University, Vilnius, Lithuania; Department of Psychosocial Rehabilitation, Vilnius Mental Health Center, Vilnius, Lithuania; Department for Psychosis Treatment, Vilnius Mental Health Center, Vilnius, Lithuania4 aut |
| 700 | 1 | a Hilbig, J.u Department of Clinic of Psychiatric, Faculty of Medicine, Vilnius University, Vilnius, Lithuania; Department of Psychosocial Rehabilitation, Vilnius Mental Health Center, Vilnius, Lithuania; Department for Psychosis Treatment, Vilnius Mental Health Center, Vilnius, Lithuania4 aut |
| 700 | 1 | a Bukelskis, L.u Department of Clinic of Psychiatric, Faculty of Medicine, Vilnius University, Vilnius, Lithuania; Department of Psychosocial Rehabilitation, Vilnius Mental Health Center, Vilnius, Lithuania; Department for Psychosis Treatment, Vilnius Mental Health Center, Vilnius, Lithuania4 aut |
| 700 | 1 | a Stevovic, L.I.u Clinical Department of Psychiatry, Clinical Centre of Montenegro, Podgorica, Montenegro; Department of Psychiatry, School of Medicine, University of Montenegro, Podgorica, Montenegro; Clinical Department of Neurology, Clinical Centre of Montenegro, Podgorica, Montenegro4 aut |
| 700 | 1 | a Vodopic, S.u Clinical Department of Psychiatry, Clinical Centre of Montenegro, Podgorica, Montenegro; Department of Psychiatry, School of Medicine, University of Montenegro, Podgorica, Montenegro; Clinical Department of Neurology, Clinical Centre of Montenegro, Podgorica, Montenegro4 aut |
| 700 | 1 | a Esan, O.u Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria4 aut |
| 700 | 1 | a Oladele, O.u Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria4 aut |
| 700 | 1 | a Osunbote, C.u Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria4 aut |
| 700 | 1 | a Rybakowski, J.K.u Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland4 aut |
| 700 | 1 | a Wojciak, P.u Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland4 aut |
| 700 | 1 | a Domowicz, K.u Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland4 aut |
| 700 | 1 | a Figueira, M.L.u Department of Psychiatry and Mental Health, Santa Maria University Hospital, Lisbon, Portugal4 aut |
| 700 | 1 | a Linhares, L.u Department of Psychiatry and Mental Health, Santa Maria University Hospital, Lisbon, Portugal4 aut |
| 700 | 1 | a Crawford, J.u Department of Psychiatry and Mental Health, Santa Maria University Hospital, Lisbon, Portugal4 aut |
| 700 | 1 | a Panfil, A.-L.u University of Medicine and Pharmacy of Târgu Mures, Târgu Mures, Romania4 aut |
| 700 | 1 | a Smirnova, D.u Department of Psychiatry, Samara Psychiatric Hospital, Inpatient Unit, Samara State Medical University, Samara, Russian Federation4 aut |
| 700 | 1 | a Izmailova, O.u Department of Psychiatry, Samara Psychiatric Hospital, Inpatient Unit, Samara State Medical University, Samara, Russian Federation4 aut |
| 700 | 1 | a Lecic-Tosevski, D.u Institute of Mental Health, Belgrade, Serbia; Serbian Academy of Sciences and Arts, Belgrade, Serbia4 aut |
| 700 | 1 | a Temmingh, H.u Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa4 aut |
| 700 | 1 | a Howells, F.u Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa4 aut |
| 700 | 1 | a Bobes, J.u Department of Psychiatry, University of Oviedo, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Oviedo, Spain4 aut |
| 700 | 1 | a Garcia-Portilla, M.P.u Department of Psychiatry, University of Oviedo, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Oviedo, Spain4 aut |
| 700 | 1 | a Garciá-Alvarez, L.u Department of Psychiatry, University of Oviedo, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Oviedo, Spain4 aut |
| 700 | 1 | a Erzin, G.u Psychiatry Department, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey4 aut |
| 700 | 1 | a Karada, H.u Psychiatry Department, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey4 aut |
| 700 | 1 | a De, Sousa A.u Department of Psychiatry, Lokmanya Tilak Municipal Medical College, Mumbai, India4 aut |
| 700 | 1 | a Bendre, A.u Department of Psychiatry, Lokmanya Tilak Municipal Medical College, Mumbai, India4 aut |
| 700 | 1 | a Hoschl, C.u National Institute of Mental Health, Klecany, Czech Republic4 aut |
| 700 | 1 | a Bredicean, C.u University of Medicine, Pharmacy of Timisoara, Timisoara, Romania4 aut |
| 700 | 1 | a Papava, I.u University of Medicine, Pharmacy of Timisoara, Timisoara, Romania4 aut |
| 700 | 1 | a Vukovic, O.u Institute of Mental Health, School of Medicine, University of Belgrade, Belgrade, Serbia4 aut |
| 700 | 1 | a Pejuskovic, B.u Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland4 aut |
| 700 | 1 | a Russell, V.u Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland4 aut |
| 700 | 1 | a Athanasiadis, L.u 1st Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece4 aut |
| 700 | 1 | a Konsta, A.u 1st Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece4 aut |
| 700 | 1 | a Stein, D.u Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa; MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa4 aut |
| 700 | 1 | a Berk, M.u IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Australia; Orygen, National Centre of Excellence in Youth Mental Health, Parkville, VIC, Australia; Centre for Youth Mental Health, Florey Institute for Neuroscience and Mental Health, Parkville, VIC, Australia; Department of Psychiatry, University of Melbourne, Parkville, VIC, Australia4 aut |
| 700 | 1 | a Dean, O.u IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Australia; Orygen, National Centre of Excellence in Youth Mental Health, Parkville, VIC, Australia; Centre for Youth Mental Health, Florey Institute for Neuroscience and Mental Health, Parkville, VIC, Australia; Department of Psychiatry, University of Melbourne, Parkville, VIC, Australia4 aut |
| 700 | 1 | a Tandon, R.u Department of Psychiatry, University of Florida, Gainesville, FL, United States4 aut |
| 700 | 1 | a Kasper, S.u Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria4 aut |
| 700 | 1 | a De, Hert M.u University Psychiatric Center, Katholieke Universiteit Leuven, Kortenberg, Belgium; Department of Neurosciences, Katholieke Universiteit Leuven, Leuven, Belgium; Antwerp Health Law and Ethics Chair, AHLEC University, Antwerpen, Belgium4 aut |
| 710 | 2 | a Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greeceb Avdelningen för prevention, rehabilitering och nära vård4 org |
| 773 | 0 | t CNS Spectrumsd : Cambridge University Pressg 26:3, s. 290-298q 26:3<290-298x 1092-8529x 2165-6509 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-174557 |
| 856 | 4 8 | u https://doi.org/10.1017/S1092852920001091 |
- 15 av 33
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Hitta mer i SwePub
- Av författaren/redakt...
- Fountoulakis, K. ...
- Dragioti, Elena, ...
- Theofilidis, A.T ...
- Wiklund, Tobias, ...
- Atmatzidis, Xeno ...
- Nimatoudis, I.
- visa fler...
- Thys, E.
- Wampers, M.
- Hranov, L.
- Hristova, T.
- Aptalidis, D.
- Milev, R.
- Iftene, F.
- Spaniel, F.
- Knytl, P.
- Furstova, P.
- From, T.
- Karlsson, H.
- Walta, M.
- Salokangas, R.K. ...
- Azorin, J.-M.
- Bouniard, J.
- Montant, J.
- Juckel, G.
- Haussleiter, I.S ...
- Douzenis, A.
- Michopoulos, I.
- Ferentinos, P.
- Smyrnis, N.
- Mantonakis, L.
- Nemes, Z.
- Gonda, X.
- Vajda, D.
- Juhasz, A.
- Shrivastava, A.
- Waddington, J.
- Pompili, M.
- Comparelli, A.
- Corigliano, V.
- Rancans, E.
- Navickas, A.
- Hilbig, J.
- Bukelskis, L.
- Stevovic, L.I.
- Vodopic, S.
- Esan, O.
- Oladele, O.
- Osunbote, C.
- Rybakowski, J.K.
- Wojciak, P.
- Domowicz, K.
- Figueira, M.L.
- Linhares, L.
- Crawford, J.
- Panfil, A.-L.
- Smirnova, D.
- Izmailova, O.
- Lecic-Tosevski, ...
- Temmingh, H.
- Howells, F.
- Bobes, J.
- Garcia-Portilla, ...
- Garciá-Alvarez, ...
- Erzin, G.
- Karada, H.
- De, Sousa A.
- Bendre, A.
- Hoschl, C.
- Bredicean, C.
- Papava, I.
- Vukovic, O.
- Pejuskovic, B.
- Russell, V.
- Athanasiadis, L.
- Konsta, A.
- Stein, D.
- Berk, M.
- Dean, O.
- Tandon, R.
- Kasper, S.
- De, Hert M.
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