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Disability, fatigue...
Disability, fatigue, pain and their associates in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study.
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- Peytrignet, Sébastien (author)
- University of Manchester
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- Denton, Christopher P (author)
- University College London
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- Lunt, Mark (author)
- University of Manchester
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- Hesselstrand, Roger (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Mouthon, Luc (author)
- Paris Descartes University
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- Silman, Alan (author)
- University of Oxford
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- Pan, Xiaoyan (author)
- University of Manchester
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- Brown, Edith (author)
- University of Manchester
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- Czirják, László (author)
- University of Pécs
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- Distler, Jörg H W (author)
- Friedrich-Alexander University Erlangen-Nürnberg
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- Distler, Oliver (author)
- University of Zurich
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- Fligelstone, Kim (author)
- University College London
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- Gregory, William J (author)
- Great Ormond Street Hospital
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- Ochiel, Rachel (author)
- University College London
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- Vonk, Madelon (author)
- Radboud University Nijmegen
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- Ancuta, Codrina (author)
- Grigore T. Popa University of Medicine and Pharmacy
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- Ong, Voon H (author)
- University College London
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- Farge, Dominique (author)
- Saint-Louis Hospital, Paris
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- Hudson, Marie (author)
- McGill University,Jewish General Hospital
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- Matucci-Cerinic, Marco (author)
- University of Florence
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- Balbir-Gurman, Alexandra (author)
- Technion - Israel Institute of Technology
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- Midtvedt, Øyvind (author)
- Norwegian Radium Hospital
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- Jordan, Alison C (author)
- New Queen Elizabeth Hospital
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- Stevens, Wendy (author)
- St. Vincent's Hospital, Melbourne
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- Moinzadeh, Pia (author)
- University of Cologne
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- Hall, Frances C (author)
- University of Cambridge
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- Agard, Christian (author)
- University of Nantes
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- Anderson, Marina E (author)
- University of Liverpool
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- Diot, Elisabeth (author)
- Hopital Bretonneau
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- Madhok, Rajan (author)
- Glasgow Royal Infirmary
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- Akil, Mohammed (author)
- Sheffield Teaching Hospitals
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- Buch, Maya H (author)
- University of Leeds,Leeds Teaching Hospitals NHS Trust
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- Chung, Lorinda (author)
- Stanford University
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- Damjanov, Nemanja (author)
- University of Belgrade
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- Gunawardena, Harsha (author)
- North Bristol NHS Trust
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- Lanyon, Peter (author)
- Nottingham NHS Treatment Centre,Nottingham University Hospitals NHS Trust
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- Ahmad, Yasmeen (author)
- Llandudno Hospital
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- Chakravarty, Kuntal (author)
- Queen's Hospital, Romford
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- Jacobsen, Søren (author)
- University of Copenhagen
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- MacGregor, Alexander J (author)
- University of East Anglia
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- McHugh, Neil (author)
- Royal National Hospital for Rheumatic Diseases
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- Müller-Ladner, Ulf (author)
- Justus Liebig University Giessen
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- Riemekasten, Gabriela (author)
- British Columbia Children's Hospital
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- Becker, Michael (author)
- Charité - University Medicine Berlin
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- Roddy, Janet (author)
- Royal Perth Hospital
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- Carreira, Patricia E (author)
- 12 de Octubre University Hospital
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- Fauchais, Anne Laure (author)
- University Hospital Of Limoges
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- Hachulla, Eric (author)
- University of Lille
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- Hamilton, Jennifer (author)
- Gateshead Hospitals Foundation Trust
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- Inanç, Murat (author)
- Istanbul University
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- McLaren, John S (author)
- Whyteman's Brae Hospital
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- van Laar, Jacob M (author)
- University Medical Center Utrecht
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- Pathare, Sanjay (author)
- James Cook University Hospital
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- Proudman, Susanna (author)
- University of Adelaide
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- Rudin, Anna, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Sahlgrenska Academy
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- Sahhar, Joanne (author)
- Monash University
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- Serratrice, Christine (author)
- Hospital Saint Joseph
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- Sheeran, Tom (author)
- Cannock Chase Hospital
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- Veale, Douglas J (author)
- St Vincent's University Hospital
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- Grange, Claire (author)
- Centre Hospitalier Lyon Sud
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- Trad, Georges-Selim (author)
- CHU Ambroise Paré
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- Herrick, Ariane L (author)
- Christie NHS Foundation Trust,University of Manchester
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- Coppere, Brigitte (author)
- Hôpital Edouard Herriot
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(creator_code:org_t)
- 2017-11-30
- 2018
- English.
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In: Rheumatology (Oxford, England). - : Oxford University Press (OUP). - 1462-0332 .- 1462-0324. ; 57:2, s. 370-381
- Related links:
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https://europepmc.or...
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- Our aim was to describe the burden of early dcSSc in terms of disability, fatigue and pain in the European Scleroderma Observational Study cohort, and to explore associated clinical features.Patients completed questionnaires at study entry, 12 and 24 months, including the HAQ disability index (HAQ-DI), the Cochin Hand Function Scale (CHFS), the Functional Assessment of Chronic Illness Therapy-fatigue and the Short Form 36 (SF36). Associates examined included the modified Rodnan skin score (mRSS), current digital ulcers and internal organ involvement. Correlations between 12-month changes were also examined.The 326 patients recruited (median disease duration 11.9 months) displayed high levels of disability [mean (s.d.) HAQ-DI 1.1 (0.83)], with 'grip' and 'activity' being most affected. Of the 18 activities assessed in the CHFS, those involving fine finger movements were most affected. High HAQ-DI and CHFS scores were both associated with high mRSS (ρ = 0.34, P < 0.0001 and ρ = 0.35, P < 0.0001, respectively). HAQ-DI was higher in patients with digital ulcers (P = 0.004), pulmonary fibrosis (P = 0.005), cardiac (P = 0.005) and muscle involvement (P = 0.002). As anticipated, HAQ-DI, CHFS, the Functional Assessment of Chronic Illness Therapy and SF36 scores were all highly correlated, in particular the HAQ-DI with the CHFS (ρ = 0.84, P < 0.0001). Worsening HAQ-DI over 12 months was strongly associated with increasing mRSS (ρ = 0.40, P < 0.0001), decreasing hand function (ρ = 0.57, P < 0.0001) and increasing fatigue (ρ = -0.53, P < 0.0001).The European Scleroderma Observational Study highlights the burden of disability in early dcSSc, with high levels of disability and fatigue, associating with the degree of skin thickening (mRSS). Impaired hand function is a major contributor to overall disability.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Adult
- Cost of Illness
- Disability Evaluation
- Europe
- Fatigue
- etiology
- physiopathology
- Female
- Fingers
- Hand Strength
- Health Surveys
- Humans
- Male
- Pain
- etiology
- physiopathology
- Prospective Studies
- Scleroderma
- Diffuse
- complications
- physiopathology
- Severity of Illness Index
- Skin Ulcer
- etiology
- physiopathology
- Disability
- Early diffuse cutaneous systemic sclerosis
- Hand function
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Peytrignet, Séba ...
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Denton, Christop ...
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Lunt, Mark
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Hesselstrand, Ro ...
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Mouthon, Luc
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Silman, Alan
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show more...
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Pan, Xiaoyan
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Brown, Edith
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Czirják, László
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Distler, Jörg H ...
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Distler, Oliver
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Fligelstone, Kim
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Gregory, William ...
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Ochiel, Rachel
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Vonk, Madelon
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Ancuta, Codrina
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Ong, Voon H
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Farge, Dominique
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Hudson, Marie
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Matucci-Cerinic, ...
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Balbir-Gurman, A ...
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Midtvedt, Øyvind
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Jordan, Alison C
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Stevens, Wendy
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Moinzadeh, Pia
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Hall, Frances C
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Agard, Christian
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Anderson, Marina ...
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Diot, Elisabeth
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Madhok, Rajan
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Akil, Mohammed
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Buch, Maya H
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Chung, Lorinda
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Damjanov, Nemanj ...
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Gunawardena, Har ...
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Lanyon, Peter
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Ahmad, Yasmeen
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Chakravarty, Kun ...
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Jacobsen, Søren
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MacGregor, Alexa ...
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McHugh, Neil
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Müller-Ladner, U ...
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Riemekasten, Gab ...
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Becker, Michael
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Roddy, Janet
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Carreira, Patric ...
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Fauchais, Anne L ...
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Hachulla, Eric
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Hamilton, Jennif ...
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Inanç, Murat
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McLaren, John S
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van Laar, Jacob ...
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Pathare, Sanjay
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Proudman, Susann ...
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Rudin, Anna, 196 ...
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Sahhar, Joanne
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Serratrice, Chri ...
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Sheeran, Tom
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Veale, Douglas J
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Grange, Claire
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Trad, Georges-Se ...
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Herrick, Ariane ...
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Coppere, Brigitt ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Rheumatology (Ox ...
- By the university
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University of Gothenburg
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Lund University