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FältnamnIndikatorerMetadata
00008989naa a2200697 4500
001oai:DiVA.org:umu-189825
003SwePub
008211125s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1898252 URI
0247 a https://doi.org/10.1186/s12933-021-01413-42 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Sinning, Christophu Department of Cardiology, University Heart & Vascular Center Hamburg, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany4 aut
2451 0a Association of glycated hemoglobin A1c levels with cardiovascular outcomes in the general population :b results from the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium
264 c 2021-11-15
264 1b BioMed Central,c 2021
338 a electronic2 rdacarrier
520 a Background: Biomarkers may contribute to improved cardiovascular risk estimation. Glycated hemoglobin A1c (HbA1c) is used to monitor the quality of diabetes treatment. Its strength of association with cardiovascular outcomes in the general population remains uncertain. This study aims to assess the association of HbA1c with cardiovascular outcomes in the general population.Methods: Data from six prospective population-based cohort studies across Europe comprising 36,180 participants were analyzed. HbA1c was evaluated in conjunction with classical cardiovascular risk factors (CVRFs) for association with cardiovascular mortality, cardiovascular disease (CVD) incidence, and overall mortality in subjects without diabetes (N = 32,496) and with diabetes (N = 3684).Results: Kaplan–Meier curves showed higher event rates with increasing HbA1c levels (log-rank-test: p < 0.001). Cox regression analysis revealed significant associations between HbA1c (in mmol/mol) in the total study population and the examined outcomes. Thus, a hazard ratio (HR) of 1.16 (95% confidence interval (CI) 1.02–1.31, p = 0.02) for cardiovascular mortality, 1.13 (95% CI 1.03–1.24, p = 0.01) for CVD incidence, and 1.09 (95% CI 1.02–1.17, p = 0.01) for overall mortality was observed per 10 mmol/mol increase in HbA1c. The association with CVD incidence and overall mortality was also observed in study participants without diabetes with increased HbA1c levels (HR 1.12; 95% CI 1.01–1.25, p = 0.04) and HR 1.10; 95% CI 1.01–1.20, p = 0.02) respectively. HbA1c cut-off values of 39.9 mmol/mol (5.8%), 36.6 mmol/mol (5.5%), and 38.8 mmol/mol (5.7%) for cardiovascular mortality, CVD incidence, and overall mortality, showed also an increased risk.Conclusions: HbA1c is independently associated with cardiovascular mortality, overall mortality and cardiovascular disease in the general European population. A mostly monotonically increasing relationship was observed between HbA1c levels and outcomes. Elevated HbA1c levels were associated with cardiovascular disease incidence and overall mortality in participants without diabetes underlining the importance of HbA1c levels in the overall population.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe)
653 a Biomarkers
653 a Cardiovascular risk
653 a Glycated hemoglobin A1c (HbA1c)
653 a MORGAM (MONICA Risk Genetics Archiving and Monograph)
653 a Mortality
7001 a Makarova, Nataliyau Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf, Hamburg, Germany4 aut
7001 a Völzke, Henryu Department of Study of Health in Pomerania/Clinical-Epidemiological Research, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany4 aut
7001 a Schnabel, Renate B.u Department of Cardiology, University Heart & Vascular Center Hamburg, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany4 aut
7001 a Ojeda, Franciscou Department of Cardiology, University Heart & Vascular Center Hamburg, Hamburg, Germany4 aut
7001 a Dörr, Marcusu German Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany; Department of Internal Medicine B, University of Medicine Greifswald, Greifswald, Germany4 aut
7001 a Felix, Stephan B.u German Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany; Department of Internal Medicine B, University of Medicine Greifswald, Greifswald, Germany4 aut
7001 a Koenig, Wolfgangu German Heart Center Munich, Technical University, Munich, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany4 aut
7001 a Peters, Annetteu German Research Center for Environmental Health, Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany4 aut
7001 a Rathmann, Wolfgangu Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany4 aut
7001 a Schöttker, Benu Division of Clinical Epidemiology and Ageing Research, German Cancer Research Center, Heidelberg, Germany; Network Aging Research, University of Heidelberg, Heidelberg, Germany4 aut
7001 a Brenner, Hermannu Division of Clinical Epidemiology and Ageing Research, German Cancer Research Center, Heidelberg, Germany; Network Aging Research, University of Heidelberg, Heidelberg, Germany4 aut
7001 a Veronesi, Giovanniu Department of Medicine and Surgery, EPIMED Research Center, University of Insubria at Varese, Varese, Italy4 aut
7001 a Cesana, Giancarlou Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy4 aut
7001 a Brambilla, Paolou Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy4 aut
7001 a Palosaari, Tarjau Finnish Institute for Health and Welfare, Division Public Health and Welfare, Helsinki, Finland4 aut
7001 a Kuulasmaa, Kariu Finnish Institute for Health and Welfare, Division Public Health and Welfare, Helsinki, Finland4 aut
7001 a Njølstad, Ingeru Department of Community Medicine, UiT The Arctic University of Norway, Tromsö, Norway4 aut
7001 a Bøgeberg Mathiesen, Ellisivu Brain and Circulation Research Group, UiT The Arctic University of Norway, Tromsö, Norway; Neurological Department, University Hospital of North Norway, Tromsö, Norway4 aut
7001 a Wilsgaard, Tomu Department of Community Medicine, UiT The Arctic University of Norway, Tromsö, Norway4 aut
7001 a Blankenberg, Stefanu Department of Cardiology, University Heart & Vascular Center Hamburg, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany4 aut
7001 a Söderberg, Stefanu Umeå universitet,Avdelningen för medicin4 aut0 (Swepub:umu)stso0001
7001 a Ferrario, Marco M.u Department of Medicine and Surgery, EPIMED Research Center, University of Insubria at Varese, Varese, Italy4 aut
7001 a Thorand, Barbarau German Research Center for Environmental Health, Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Munich, Neuherberg, Germany4 aut
7102 a Department of Cardiology, University Heart & Vascular Center Hamburg, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germanyb Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf, Hamburg, Germany4 org
7730 t Cardiovascular Diabetologyd : BioMed Centralg 20:1q 20:1x 1475-2840
8564 u https://doi.org/10.1186/s12933-021-01413-4y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1614507/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://cardiab.biomedcentral.com/track/pdf/10.1186/s12933-021-01413-4
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-189825
8564 8u https://doi.org/10.1186/s12933-021-01413-4

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