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Plasma Amyloid-β, T...
Plasma Amyloid-β, Total Tau, and Neurofilament Light Chain Across the Alzheimer's Disease Clinical Spectrum: A Population-Based Study
- Article/chapterEnglish2023
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LIBRIS-ID:oai:gup.ub.gu.se/332290
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https://gup.ub.gu.se/publication/332290URI
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https://doi.org/10.3233/JAD-230932DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-224676URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:154343890URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Background: Plasma biomarkers have emerged as a promising approach for characterizing pathophysiology in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Objective: We aimed to characterize plasma biomarkers for AD and neurodegeneration across the AD clinical continuum, and to assess their ability to differentiate between AD, MCI, and normal cognition. Methods: This population-based study engaged 1,446 rural-dwelling older adults (age >= 60 years, 61.0% women) derived from MIND-China; of these, 402 were defined with MCI and 142 with AD. Plasma amyloid-beta (A beta), total tau (t-tau), and neurofilament light chain (NfL) concentrations were analyzed using the Simoa platform. Data were analyzed using linear and logistic regression models, and receiver operating characteristic (ROC) analysis. Results: Across the AD clinical spectrum, plasma A beta(40) and NfL increased, whereas A beta(42)/A beta(40) ratio decreased. Plasma t-tau was higher in people withADdementia than those with MCI or normal cognition. Plasma NfL outperformed other biomarkers in differentiating AD from normal cognition (area under the ROC curve [AUC] = 0.75), but all plasma biomarkers performed poorly to distinguish MCI from normal cognition (AUC <0.60). Plasma NfL in combination with age, sex, education, and APOE genotype yielded the AUC of 0.87 for differentiating between AD and normal cognition, 0.79 between AD and MCI, and 0.64 between MCI and normal cognition. Conclusions: In this Chinese population, AD plasma biomarkers vary by age, sex, and APOE genotype. Plasma A beta, t-tau, and NfL differ across the AD clinical spectrum, and plasma NfL appears to be superior to plasma A beta and t-tau for defining the clinical spectrum.
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Hou, Tingting
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Li, Yuanjing
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Liu, Rui
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Cong, Lin
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Liu, Keke
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Liu, CuicuiKarolinska Institutet
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Han, Xiaolei
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Ren, Yifei
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Tang, Shi
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Winblad, BengtKarolinska Institutet
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Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka
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Wang, YongxiangStockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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Du, Yifeng
(author)
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Qiu, ChengxuanStockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
(creator_code:org_t)
Related titles
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In:JOURNAL OF ALZHEIMERS DISEASE96:2, s. 845-8581387-28771875-8908
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- By the author/editor
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Dong, Yi
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Hou, Tingting
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Li, Yuanjing
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Liu, Rui
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Cong, Lin
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Liu, Keke
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show more...
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Liu, Cuicui
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Han, Xiaolei
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Ren, Yifei
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Tang, Shi
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Winblad, Bengt
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Blennow, Kaj, 19 ...
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Wang, Yongxiang
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Du, Yifeng
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Qiu, Chengxuan
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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JOURNAL OF ALZHE ...
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University of Gothenburg
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Stockholm University
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Karolinska Institutet