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Sökning: WFRF:(Wahlberg Jeanette) > (2020-2024) > Reference intervals...

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FältnamnIndikatorerMetadata
00008427naa a2200997 4500
001oai:gup.ub.gu.se/296151
003SwePub
008240528s2020 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-180275
009oai:DiVA.org:liu-174306
009oai:DiVA.org:uu-441103
009oai:prod.swepub.kib.ki.se:146151326
009oai:lup.lub.lu.se:bbee6383-6f24-4ded-b244-64435614964d
0247 a https://gup.ub.gu.se/publication/2961512 URI
0247 a https://doi.org/10.1530/EJE-19-08722 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1802752 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1743062 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4411032 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1461513262 URI
0247 a https://lup.lub.lu.se/record/bbee6383-6f24-4ded-b244-64435614964d2 URI
040 a (SwePub)gud (SwePub)umud (SwePub)liud (SwePub)uud (SwePub)kid (SwePub)lu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bäcklund, Nilsu Umeå University,Umeå universitet,Avdelningen för medicin,Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden,Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden4 aut0 (Swepub:umu)niba0024
2451 0a Reference intervals of salivary cortisol and cortisone and their diagnostic accuracy in Cushing's syndrome
264 1b Bioscientifica,c 2020
500 a This study was supported by a donation to Umeå University for research on pituitary disease.
520 a Objective: The challenge of diagnosing Cushing's syndrome (CS) calls for high precision biochemical screening. This study aimed to establish robust reference intervals for, and compare the diagnostic accuracy of, salivary cortisol and cortisone in late-night samples and after a low-dose (1 mg) dexamethasone suppression test (DST). Design and methods: Saliva samples were collected at 08:00 and 23:00 h, and at 08:00 h, after a DST, from 22 patients with CS and from 155 adult reference subjects. We also collected samples at 20:00 and 22:00 h from 78 of the reference subjects. Salivary cortisol and cortisone were analysed with liquid chromatography-tandem mass spectrometry. The reference intervals were calculated as the 2.5th and 97.5th percentiles of the reference population measurements. Diagnostic accuracies of different tests were compared, based on areas under the receiver-operating characteristic curves. Results: The upper reference limits of salivary cortisol and cortisone at 23:00 h were 3.6 nmol/L and 13.5 nmol/L, respectively. Using these reference limits, CS was detected with a sensitivity (95% CI) of 90% (70-99%) and specificity of 96% (91-98%) for cortisol, and a 100% (84-100%) sensitivity and 95% (90-98%) specificity for cortisone. After DST, cortisol and cortisone upper reference limits were 0.79 nmol/L and 3.5 nmol/L, respectively. CS was detected with 95% (75-100%) sensitivity and 96% (92-99%) specificity with cortisol, and 100% (83-100%) sensitivity and 94% (89-97%) specificity with cortisone. No differences in salivary cortisol or cortisone levels were found between samples collected at 22:00 and 23:00 h. Conclusion: Salivary cortisol and cortisone in late-night samples and after DST showed high accuracy for diagnosing CS, salivary cortisone being slightly, but significantly better. © 2020 European Society of Endocrinology Printed in Great Britain.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650 7a NATURVETENSKAPx Kemix Analytisk kemi0 (SwePub)104012 hsv//swe
650 7a NATURAL SCIENCESx Chemical Sciencesx Analytical Chemistry0 (SwePub)104012 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Annan medicin och hälsovetenskapx Gerontologi, medicinsk/hälsovetenskaplig inriktning0 (SwePub)305022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Other Medical and Health Sciencesx Gerontology, specialising in Medical and Health Sciences0 (SwePub)305022 hsv//eng
653 a cortisone
653 a dexamethasone
653 a hydrocortisone
653 a adult
653 a aged
653 a area under the curve
653 a chemistry
653 a circadian rhythm
653 a Cushing syndrome
653 a female
653 a human
653 a male
653 a mass screening
653 a middle aged
653 a procedures
653 a receiver operating characteristic
653 a reference value
653 a saliva
653 a sensitivity and specificity
653 a tandem mass spectrometry
653 a time factor
653 a very elderly
653 a young adult
653 a Aged
653 a 80 and over
653 a Area Under Curve
653 a Humans
653 a Reference Values
653 a ROC Curve
653 a Time Factors
7001 a Brattsand, Göranu Umeå University,Umeå universitet,Klinisk kemi,Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden,Umeå Univ, Dept Med Biosci, Clin Chem, Umeå, Sweden4 aut0 (Swepub:umu)gobr0001
7001 a Israelsson, Marlenu Umeå University,Umeå universitet,Klinisk kemi,Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden,Umeå Univ, Dept Med Biosci, Clin Chem, Umeå, Sweden4 aut0 (Swepub:umu)mais0016
7001 a Ragnarsson, Oskar,d 1971u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden,Univ Gothenburg, Inst Med, Dept Internal Med & Clin Nutr, Sahlgrenska Acad, Gothenburg, Sweden; Sahlgrens Univ Hosp, Dept Endocrinol, Gothenburg, Sweden4 aut0 (Swepub:gu)xragos
7001 a Burman, Piau Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-bap
7001 a Edén Engström, Brittu Uppsala University,Uppsala universitet,Endokrinologi och mineralmetabolism4 aut0 (Swepub:uu)brittee
7001 a Høybye, C.u Karolinska Institutet,Karolinska University Hospital4 aut
7001 a Berinder, K.u Karolinska Institutet,Karolinska University Hospital4 aut
7001 a Wahlberg, Jeanette,d 1969-u Linköping University,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken,Linköping Univ, Dept Med & Hlth Sci, Dept Endocrinol, Linköping, Sweden4 aut0 (Swepub:liu)jeawa98
7001 a Olsson, Tommyu Umeå University,Umeå universitet,Avdelningen för medicin,Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden,Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden4 aut0 (Swepub:umu)tool0003
7001 a Dahlqvist, Peru Umeå University,Umeå universitet,Avdelningen för medicin,Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden,Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden4 aut0 (Swepub:umu)perdat96
7102 a Umeå universitetb Avdelningen för medicin4 org
7730 t European Journal of Endocrinologyd : Bioscientificag 182:6, s. 569-582q 182:6<569-582x 0804-4643x 1479-683X
8564 u http://dx.doi.org/10.1530/EJE-19-0872y FULLTEXT
8564 8u https://gup.ub.gu.se/publication/296151
8564 8u https://doi.org/10.1530/EJE-19-0872
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-180275
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-174306
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-441103
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:146151326
8564 8u https://lup.lub.lu.se/record/bbee6383-6f24-4ded-b244-64435614964d

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