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Search: L773:1387 2877 OR L773:1875 8908 > (2020-2024) > Cognition Mediates ...

Cognition Mediates the Association Between Cerebrospinal Fluid Biomarkers of Amyloid and P-Tau and Neuropsychiatric Symptoms

Frank, Brandon (author)
Walsh, Michael (author)
Hurley, Landon (author)
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Groh, Jenna (author)
Blennow, Kaj (author)
Zetterberg, Henrik, 1973 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Tripodis, Yorghos (author)
Budson, Andrew E. (author)
O'Connor, Maureen K. (author)
Martin, Brett (author)
Weller, Jason (author)
McKee, Ann (author)
Qiu, Wendy (author)
Stein, Thor D. (author)
Stern, Robert A. (author)
Mez, Jesse (author)
Henson, Rachel (author)
Long, Justin (author)
Aschenbrenner, Andrew J. (author)
Babulal, Ganesh M. (author)
Morris, John C. (author)
Schindler, Suzanne (author)
Alosco, Michael L. (author)
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 (creator_code:org_t)
2024
2024
English.
In: JOURNAL OF ALZHEIMERS DISEASE. - 1387-2877 .- 1875-8908. ; 100:3, s. 1055-1073
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Background: Neuropsychiatric symptoms (NPS) can be an early manifestation of Alzheimer's disease (AD). However, the associations among NPS, cognition, and AD biomarkers across the disease spectrum are unclear. Objective: We analyzed cross-sectional mediation pathways between cerebrospinal fluid (CSF) biomarkers of AD (A beta(1-42), p-tau(181)), cognitive function, and NPS. Methods: Primary models included 781 participants from the National Alzheimer's Coordinating Center (NACC) data set who had CSF analyzed for AD biomarkers using Lumipulse. NPS were assessed with the Neuropsychiatric Inventory Questionnaire (NPI-Q). We assessed cognition with the harmonized MMSE/MoCA, as well as neuropsychological tests sensitive to AD pathology: story recall, naming, animal fluency, and Trails B. The Clinical Dementia Rating (CDR (R)) scale assessed dementia severity. Mediation models were estimated with Kemeny metric covariance in a structural equation model framework, controlling for age, education, sex, and APOE epsilon 4. Results: The sample was older adults (M = 73.85, SD = 6.68; 49.9% male, 390; 27.9% dementia, 218) who were predominantly white (n = 688, 88.1%). Higher p-tau(181)/A beta(1-42) ratio predicted higher NPI-Q, which was partially mediated by the MMSE/MoCA and, in a second model, story recall. No other pathway was statistically significant. Both the MMSE/MoCA and NPI-Q independently mediated the association between p-tau(181)/A beta(1-42) ratio and CDR global impairment. With dementia excluded, p-tau(181)/A beta(1-42) ratio was no longer associated with the NPI-Q. Conclusions: NPS may be secondary to cognitive impairment and AD pathology through direct and indirect pathways. NPS independently predict dementia severity in AD. However, AD pathology likely plays less of a role in NPS in samples without dementia.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Keyword

Alzheimer's disease
amyloid
biomarkers
cerebrospinal fluid
cognition
neuropsychiatric symptoms
p-tau

Publication and Content Type

ref (subject category)
art (subject category)

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