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Omics signatures li...
Omics signatures linking persistent organic pollutants to cardiovascular disease in the Swedish mammography cohort
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- Schillemans, Tessa (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Inst Environm Med, Cardiovasc & Nutr Epidemiol, S-17177 Stockholm, Sweden.
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- Yan, Yingxiao, 1997 (författare)
- Chalmers University of Technology
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- Ribbenstedt, Anton, 1986 (författare)
- Chalmers University of Technology
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- Donat-Vargas, Carolina (författare)
- Karolinska Institute,Centre for Research in Environmental Epidemiology
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- Lindh, Christian H. (författare)
- Lund University,Lunds universitet,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups
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- Kiviranta, Hannu (författare)
- Department of Health Security, National Institute for Health and Welfare, Kuopio, Finland,Natl Inst Hlth & Welf, Dept Hlth Secur, Kuopio 70701, Finland.,National Institute for Health and Welfare,Finnish National Institute for Health and Welfare
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- Rantakokko, Panu (författare)
- Department of Health Security, National Institute for Health and Welfare, Kuopio, Finland,Natl Inst Hlth & Welf, Dept Hlth Secur, Kuopio 70701, Finland.,National Institute for Health and Welfare,Finnish National Institute for Health and Welfare
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- Wolk, Alicja (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Inst Environm Med, Cardiovasc & Nutr Epidemiol, S-17177 Stockholm, Sweden.
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- Landberg, Rikard (författare)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Food and Nutrition Sciences, Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden,Chalmers Univ Technol, Dept Life Sci, Food & Nutr Sci, S-41296 Gothenburg, Sweden.;Umeå Univ, Dept Publ Hlth & Clin Med, S-90187 Umeå, Sweden.,Chalmers tekniska högskola,Chalmers University of Technology,Umeå University
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- Åkesson, Agneta (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Inst Environm Med, Cardiovasc & Nutr Epidemiol, S-17177 Stockholm, Sweden.
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- Brunius, Carl (författare)
- Uppsala universitet,Medicinsk epidemiologi,Chalmers Univ Technol, Dept Life Sci, Food & Nutr Sci, S-41296 Gothenburg, Sweden; Chalmers Univ Technol, Dept Life Sci, Chalmers Mass Spectrometry Infrastruct, S-41296 Gothenburg, Sweden,Uppsala University,Chalmers tekniska högskola,Chalmers University of Technology
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Karolinska Institutet Karolinska Inst, Inst Environm Med, Cardiovasc & Nutr Epidemiol, S-17177 Stockholm, Sweden (creator_code:org_t)
- American Chemical Society (ACS), 2024
- 2024
- Engelska.
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Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 58:2, s. 1036-1047
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://research.cha... (primary) (free)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Cardiovascular disease (CVD) development may be linked to persistent organic pollutants (POPs), including organochlorine compounds (OCs) and perfluoroalkyl and polyfluoroalkyl substances (PFAS). To explore underlying mechanisms, we investigated metabolites, proteins, and genes linking POPs with CVD risk. We used data from a nested case-control study on myocardial infarction (MI) and stroke from the Swedish Mammography Cohort - Clinical (n = 657 subjects). OCs, PFAS, and multiomics (9511 liquid chromatography-mass spectrometry (LC-MS) metabolite features; 248 proteins; 8110 gene variants) were measured in baseline plasma. POP-related omics features were selected using random forest followed by Spearman correlation adjusted for confounders. From these, CVD-related omics features were selected using conditional logistic regression. Finally, 29 (for OCs) and 12 (for PFAS) unique features associated with POPs and CVD. One omics subpattern, driven by lipids and inflammatory proteins, associated with MI (OR = 2.03; 95% CI = 1.47; 2.79), OCs, age, and BMI, and correlated negatively with PFAS. Another subpattern, driven by carnitines, associated with stroke (OR = 1.55; 95% CI = 1.16; 2.09), OCs, and age, but not with PFAS. This may imply that OCs and PFAS associate with different omics patterns with opposite effects on CVD risk, but more research is needed to disentangle potential modifications by other factors.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- LANTBRUKSVETENSKAPER -- Annan lantbruksvetenskap -- Lantbrukets arbetsmiljö och säkerhet (hsv//swe)
- AGRICULTURAL SCIENCES -- Other Agricultural Sciences -- Agricultural Occupational Health and Safety (hsv//eng)
Nyckelord
- cardiovascular disease
- genetics
- metabolomics
- multiomics
- nested case-control study
- persistent organic pollutants
- proteomics
- cardiovascular disease
- genetics
- metabolomics
- multiomics
- nested case-control study
- persistent organic pollutants
- proteomics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Schillemans, Tes ...
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Yan, Yingxiao, 1 ...
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Ribbenstedt, Ant ...
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Donat-Vargas, Ca ...
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Lindh, Christian ...
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Kiviranta, Hannu
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visa fler...
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Rantakokko, Panu
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Wolk, Alicja
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Landberg, Rikard
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Åkesson, Agneta
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Brunius, Carl
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Arbetsmedicin oc ...
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- LANTBRUKSVETENSKAPER
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LANTBRUKSVETENSK ...
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och Annan lantbruksv ...
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- Artiklar i publikationen
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Environmental Sc ...
- Av lärosätet
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Umeå universitet
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Karolinska Institutet
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Uppsala universitet
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Chalmers tekniska högskola
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Lunds universitet