WFRF:(Van de Velde M)
Sökning: WFRF:(Van de Velde M) > IBD risk loci are e...
- 18 av 131
- Föregående post
- Nästa post
- Till träfflistan
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 10238naa a2202677 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:138576159 | |
| 003 | SwePub | |
| 008 | 240701s2018 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:oru-68044 | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1385761592 URI |
| 024 | 7 | a https://doi.org/10.1038/s41467-018-04365-82 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-680442 URI |
| 040 | a (SwePub)kid (SwePub)oru | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Momozawa, Yu Unit of Animal Genomics, WELBIO, GIGA-R, Faculty of Veterinary Medicine, University of Liège (B34), Liège, Belgium; Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Science, 1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, Japan4 aut |
| 245 | 1 0 | a IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes |
| 264 | c 2018-06-21 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2018 |
| 500 | a Funding Agencies:WELBIO (CAUSIBD) BELSPO (BeMGI) Horizon 2020 (SYSCID) Fonds de la Recherche Scientifique de Belgique (F.R.S.-FNRS) 2.5020.11 Japan Agency for Medical Research and Development Ministry of Education, Culture, Sports, Sciences and Technology of the Japanese government Russian Ministry of Science and Education under 5-100 Excellence Programme VIDI grant from the Netherlands Organisation for Scientific Research (NWO) 016.136.308 Netherlands Federation of University Medical Centres Dutch Government | |
| 520 | a GWAS have identified >200 risk loci for Inflammatory Bowel Disease (IBD). The majority of disease associations are known to be driven by regulatory variants. To identify the putative causative genes that are perturbed by these variants, we generate a large transcriptome data set (nine disease-relevant cell types) and identify 23,650 cis-eQTL. We show that these are determined by ∼9720 regulatory modules, of which ∼3000 operate in multiple tissues and ∼970 on multiple genes. We identify regulatory modules that drive the disease association for 63 of the 200 risk loci, and show that these are enriched in multigenic modules. Based on these analyses, we resequence 45 of the corresponding 100 candidate genes in 6600 Crohn disease (CD) cases and 5500 controls, and show with burden tests that they include likely causative genes. Our analyses indicate that ≥10-fold larger sample sizes will be required to demonstrate the causality of individual genes using this approach. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 700 | 1 | a Dmitrieva, J4 aut |
| 700 | 1 | a Theatre, E4 aut |
| 700 | 1 | a Deffontaine, V4 aut |
| 700 | 1 | a Rahmouni, S4 aut |
| 700 | 1 | a Charloteaux, B4 aut |
| 700 | 1 | a Crins, F4 aut |
| 700 | 1 | a Docampo, E4 aut |
| 700 | 1 | a Elansary, M4 aut |
| 700 | 1 | a Gori, AS4 aut |
| 700 | 1 | a Lecut, C4 aut |
| 700 | 1 | a Mariman, R4 aut |
| 700 | 1 | a Mni, Mu Karolinska Institutet4 aut |
| 700 | 1 | a Oury, C4 aut |
| 700 | 1 | a Altukhov, I4 aut |
| 700 | 1 | a Alexeev, D4 aut |
| 700 | 1 | a Aulchenko, Y4 aut |
| 700 | 1 | a Amininejad, L4 aut |
| 700 | 1 | a Bouma, G4 aut |
| 700 | 1 | a Hoentjen, F4 aut |
| 700 | 1 | a Lowenberg, M4 aut |
| 700 | 1 | a Oldenburg, B4 aut |
| 700 | 1 | a Pierik, MJ4 aut |
| 700 | 1 | a vander Meulen-de Jong, AE4 aut |
| 700 | 1 | a van der Woude, CJ4 aut |
| 700 | 1 | a Visschedijk, MC4 aut |
| 700 | 1 | a Lathrop, M4 aut |
| 700 | 1 | a Hugot, JP4 aut |
| 700 | 1 | a Weersma, RK4 aut |
| 700 | 1 | a De Vos, M4 aut |
| 700 | 1 | a Franchimont, D4 aut |
| 700 | 1 | a Vermeire, S4 aut |
| 700 | 1 | a Kubo, M4 aut |
| 700 | 1 | a Louis, E4 aut |
| 700 | 1 | a Georges, M4 aut |
| 700 | 1 | a Abraham, C4 aut |
| 700 | 1 | a Achkar, JP4 aut |
| 700 | 1 | a Ahmad, T4 aut |
| 700 | 1 | a Ananthakrishnan, AN4 aut |
| 700 | 1 | a Andersen, V4 aut |
| 700 | 1 | a Anderson, CA4 aut |
| 700 | 1 | a Andrews, JM4 aut |
| 700 | 1 | a Annese, V4 aut |
| 700 | 1 | a Aumais, G4 aut |
| 700 | 1 | a Baidoo, L4 aut |
| 700 | 1 | a Baldassano, RN4 aut |
| 700 | 1 | a Bampton, PA4 aut |
| 700 | 1 | a Barclay, M4 aut |
| 700 | 1 | a Barrett, JC4 aut |
| 700 | 1 | a Bayless, TM4 aut |
| 700 | 1 | a Bethge, J4 aut |
| 700 | 1 | a Bitton, A4 aut |
| 700 | 1 | a Boucher, G4 aut |
| 700 | 1 | a Brand, S4 aut |
| 700 | 1 | a Brandt, B4 aut |
| 700 | 1 | a Brant, SR4 aut |
| 700 | 1 | a Buning, C4 aut |
| 700 | 1 | a Chew, A4 aut |
| 700 | 1 | a Halfvarson, Jonas,d 1970-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology4 aut0 (Swepub:oru)jshn |
| 700 | 1 | a Cleynen, I4 aut |
| 700 | 1 | a Cohain, A4 aut |
| 700 | 1 | a Croft, A4 aut |
| 700 | 1 | a Daly, MJ4 aut |
| 700 | 1 | a D'Amato, Mu Karolinska Institutet4 aut |
| 700 | 1 | a Danese, S4 aut |
| 700 | 1 | a De Jong, D4 aut |
| 700 | 1 | a Denapiene, G4 aut |
| 700 | 1 | a Denson, LA4 aut |
| 700 | 1 | a Devaney, KL4 aut |
| 700 | 1 | a Dewit, O4 aut |
| 700 | 1 | a D'Inca, R4 aut |
| 700 | 1 | a Dubinsky, M4 aut |
| 700 | 1 | a Duerr, RH4 aut |
| 700 | 1 | a Edwards, C4 aut |
| 700 | 1 | a Ellinghaus, D4 aut |
| 700 | 1 | a Essers, J4 aut |
| 700 | 1 | a Ferguson, LR4 aut |
| 700 | 1 | a Festen, EA4 aut |
| 700 | 1 | a Fleshner, P4 aut |
| 700 | 1 | a Florin, T4 aut |
| 700 | 1 | a Franke, A4 aut |
| 700 | 1 | a Fransen, K4 aut |
| 700 | 1 | a Gearry, R4 aut |
| 700 | 1 | a Gieger, C4 aut |
| 700 | 1 | a Glas, J4 aut |
| 700 | 1 | a Goyette, P4 aut |
| 700 | 1 | a Green, T4 aut |
| 700 | 1 | a Griffiths, AM4 aut |
| 700 | 1 | a Guthery, SL4 aut |
| 700 | 1 | a Hakonarson, H4 aut |
| 700 | 1 | a Halfvarson, J4 aut |
| 700 | 1 | a Hanigan, K4 aut |
| 700 | 1 | a Haritunians, T4 aut |
| 700 | 1 | a Hart, A4 aut |
| 700 | 1 | a Hawkey, C4 aut |
| 700 | 1 | a Hayward, NK4 aut |
| 700 | 1 | a Hedl, M4 aut |
| 700 | 1 | a Henderson, P4 aut |
| 700 | 1 | a Hu, XH4 aut |
| 700 | 1 | a Huang, HL4 aut |
| 700 | 1 | a Hui, KY4 aut |
| 700 | 1 | a Imielinski, M4 aut |
| 700 | 1 | a Ippoliti, A4 aut |
| 700 | 1 | a Jonaitis, L4 aut |
| 700 | 1 | a Jostins, L4 aut |
| 700 | 1 | a Karlsen, TH4 aut |
| 700 | 1 | a Kennedy, NA4 aut |
| 700 | 1 | a Khan, MA4 aut |
| 700 | 1 | a Kiudelis, G4 aut |
| 700 | 1 | a Krishnaprasad, K4 aut |
| 700 | 1 | a Kugathasan, S4 aut |
| 700 | 1 | a Kupcinskas, L4 aut |
| 700 | 1 | a Latiano, A4 aut |
| 700 | 1 | a Laukens, D4 aut |
| 700 | 1 | a Lawrance, IC4 aut |
| 700 | 1 | a Lee, JC4 aut |
| 700 | 1 | a Lees, CW4 aut |
| 700 | 1 | a Leja, M4 aut |
| 700 | 1 | a Van Limbergen, J4 aut |
| 700 | 1 | a Lionetti, P4 aut |
| 700 | 1 | a Liu, JZ4 aut |
| 700 | 1 | a Mahy, G4 aut |
| 700 | 1 | a Mansfield, J4 aut |
| 700 | 1 | a Massey, D4 aut |
| 700 | 1 | a Mathew, CG4 aut |
| 700 | 1 | a McGovern, DPB4 aut |
| 700 | 1 | a Milgrom, R4 aut |
| 700 | 1 | a Mitrovic, M4 aut |
| 700 | 1 | a Montgomery, GW4 aut |
| 700 | 1 | a Mowat, C4 aut |
| 700 | 1 | a Newman, W4 aut |
| 700 | 1 | a Ng, A4 aut |
| 700 | 1 | a Ng, SC4 aut |
| 700 | 1 | a Ng, SME4 aut |
| 700 | 1 | a Nikolaus, S4 aut |
| 700 | 1 | a Ning, K4 aut |
| 700 | 1 | a Nothen, M4 aut |
| 700 | 1 | a Oikonomou, I4 aut |
| 700 | 1 | a Palmieri, O4 aut |
| 700 | 1 | a Parkes, M4 aut |
| 700 | 1 | a Phillips, A4 aut |
| 700 | 1 | a Ponsioen, CY4 aut |
| 700 | 1 | a Potocnik, U4 aut |
| 700 | 1 | a Prescott, NJ4 aut |
| 700 | 1 | a Proctor, DD4 aut |
| 700 | 1 | a Radford-Smith, G4 aut |
| 700 | 1 | a Rahier, JF4 aut |
| 700 | 1 | a Raychaudhuri, S4 aut |
| 700 | 1 | a Regueiro, M4 aut |
| 700 | 1 | a Rieder, F4 aut |
| 700 | 1 | a Rioux, JD4 aut |
| 700 | 1 | a Ripke, S4 aut |
| 700 | 1 | a Roberts, R4 aut |
| 700 | 1 | a Russell, RK4 aut |
| 700 | 1 | a Sanderson, JD4 aut |
| 700 | 1 | a Sans, M4 aut |
| 700 | 1 | a Satsangi, J4 aut |
| 700 | 1 | a Schadt, EE4 aut |
| 700 | 1 | a Schreiber, S4 aut |
| 700 | 1 | a Schulte, D4 aut |
| 700 | 1 | a Schumm, LP4 aut |
| 700 | 1 | a Scott, R4 aut |
| 700 | 1 | a Seielstad, M4 aut |
| 700 | 1 | a Sharma, Y4 aut |
| 700 | 1 | a Silverberg, MS4 aut |
| 700 | 1 | a Simms, LA4 aut |
| 700 | 1 | a Skieceviciene, J4 aut |
| 700 | 1 | a Spain, SL4 aut |
| 700 | 1 | a Steinhart, AH4 aut |
| 700 | 1 | a Stempak, JM4 aut |
| 700 | 1 | a Stronati, L4 aut |
| 700 | 1 | a Sventoraityte, J4 aut |
| 700 | 1 | a Targan, SR4 aut |
| 700 | 1 | a Taylor, KM4 aut |
| 700 | 1 | a ter Velde, A4 aut |
| 700 | 1 | a Torkvist, Lu Karolinska Institutet4 aut |
| 700 | 1 | a Tremelling, M4 aut |
| 700 | 1 | a van Sommeren, S4 aut |
| 700 | 1 | a Vasiliauskas, E4 aut |
| 700 | 1 | a Verspaget, HW4 aut |
| 700 | 1 | a Walters, T4 aut |
| 700 | 1 | a Wang, K4 aut |
| 700 | 1 | a Wang, MH4 aut |
| 700 | 1 | a Wei, Z4 aut |
| 700 | 1 | a Whiteman, D4 aut |
| 700 | 1 | a Wijmenga, C4 aut |
| 700 | 1 | a Wilson, DC4 aut |
| 700 | 1 | a Winkelmann, J4 aut |
| 700 | 1 | a Xavier, RJ4 aut |
| 700 | 1 | a Zhang, B4 aut |
| 700 | 1 | a Zhang, CK4 aut |
| 700 | 1 | a Zhang, H4 aut |
| 700 | 1 | a Zhang, W4 aut |
| 700 | 1 | a Zhao, HYu Department of Biostatistics, School of Public Health, Yale University, New Haven CT, United States4 aut |
| 700 | 1 | a Zhao, ZZ4 aut |
| 710 | 2 | a Karolinska Institutetb Unit of Animal Genomics, WELBIO, GIGA-R, Faculty of Veterinary Medicine, University of Liège (B34), Liège, Belgium; Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Science, 1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, Japan4 org |
| 773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 9:1, s. 2427-q 9:1<2427-x 2041-1723 |
| 856 | 4 | u https://www.nature.com/articles/s41467-018-04365-8.pdf |
| 856 | 4 | u https://doi.org/10.1038/s41467-018-04365-8y Fulltext |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:138576159 |
| 856 | 4 8 | u https://doi.org/10.1038/s41467-018-04365-8 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-68044 |
- 18 av 131
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Momozawa, Y
- Dmitrieva, J
- Theatre, E
- Deffontaine, V
- Rahmouni, S
- Charloteaux, B
- visa fler...
- Crins, F
- Docampo, E
- Elansary, M
- Gori, AS
- Lecut, C
- Mariman, R
- Mni, M
- Oury, C
- Altukhov, I
- Alexeev, D
- Aulchenko, Y
- Amininejad, L
- Bouma, G
- Hoentjen, F
- Lowenberg, M
- Oldenburg, B
- Pierik, MJ
- vander Meulen-de ...
- van der Woude, C ...
- Visschedijk, MC
- Lathrop, M
- Hugot, JP
- Weersma, RK
- De Vos, M
- Franchimont, D
- Vermeire, S
- Kubo, M
- Louis, E
- Georges, M
- Abraham, C
- Achkar, JP
- Ahmad, T
- Ananthakrishnan, ...
- Andersen, V
- Anderson, CA
- Andrews, JM
- Annese, V
- Aumais, G
- Baidoo, L
- Baldassano, RN
- Bampton, PA
- Barclay, M
- Barrett, JC
- Bayless, TM
- Bethge, J
- Bitton, A
- Boucher, G
- Brand, S
- Brandt, B
- Brant, SR
- Buning, C
- Chew, A
- Halfvarson, Jona ...
- Cleynen, I
- Cohain, A
- Croft, A
- Daly, MJ
- D'Amato, M
- Danese, S
- De Jong, D
- Denapiene, G
- Denson, LA
- Devaney, KL
- Dewit, O
- D'Inca, R
- Dubinsky, M
- Duerr, RH
- Edwards, C
- Ellinghaus, D
- Essers, J
- Ferguson, LR
- Festen, EA
- Fleshner, P
- Florin, T
- Franke, A
- Fransen, K
- Gearry, R
- Gieger, C
- Glas, J
- Goyette, P
- Green, T
- Griffiths, AM
- Guthery, SL
- Hakonarson, H
- Halfvarson, J
- Hanigan, K
- Haritunians, T
- Hart, A
- Hawkey, C
- Hayward, NK
- Hedl, M
- Henderson, P
- Hu, XH
- Huang, HL
- Hui, KY
- Imielinski, M
- Ippoliti, A
- Jonaitis, L
- Jostins, L
- Karlsen, TH
- Kennedy, NA
- Khan, MA
- Kiudelis, G
- Krishnaprasad, K
- Kugathasan, S
- Kupcinskas, L
- Latiano, A
- Laukens, D
- Lawrance, IC
- Lee, JC
- Lees, CW
- Leja, M
- Van Limbergen, J
- Lionetti, P
- Liu, JZ
- Mahy, G
- Mansfield, J
- Massey, D
- Mathew, CG
- McGovern, DPB
- Milgrom, R
- Mitrovic, M
- Montgomery, GW
- Mowat, C
- Newman, W
- Ng, A
- Ng, SC
- Ng, SME
- Nikolaus, S
- Ning, K
- Nothen, M
- Oikonomou, I
- Palmieri, O
- Parkes, M
- Phillips, A
- Ponsioen, CY
- Potocnik, U
- Prescott, NJ
- Proctor, DD
- Radford-Smith, G
- Rahier, JF
- Raychaudhuri, S
- Regueiro, M
- Rieder, F
- Rioux, JD
- Ripke, S
- Roberts, R
- Russell, RK
- Sanderson, JD
- Sans, M
- Satsangi, J
- Schadt, EE
- Schreiber, S
- Schulte, D
- Schumm, LP
- Scott, R
- Seielstad, M
- Sharma, Y
- Silverberg, MS
- Simms, LA
- Skieceviciene, J
- Spain, SL
- Steinhart, AH
- Stempak, JM
- Stronati, L
- Sventoraityte, J
- Targan, SR
- Taylor, KM
- ter Velde, A
- Torkvist, L
- Tremelling, M
- van Sommeren, S
- Vasiliauskas, E
- Verspaget, HW
- Walters, T
- Wang, K
- Wang, MH
- Wei, Z
- Whiteman, D
- Wijmenga, C
- Wilson, DC
- Winkelmann, J
- Xavier, RJ
- Zhang, B
- Zhang, CK
- Zhang, H
- Zhang, W
- Zhao, HY
- Zhao, ZZ
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Medicinska och f ...
- och Medicinsk geneti ...
- Artiklar i publikationen
- Nature communica ...
- Av lärosätet
- Karolinska Institutet
- Örebro universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
