SwePub
Sök i LIBRIS databas

  Utökad sökning

(WFRF:(Haiman Christopher)) lar1:(umu)
 

Sökning: (WFRF:(Haiman Christopher)) lar1:(umu) > Association of brea...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005387naa a2200817 4500
001oai:DiVA.org:umu-111131
003SwePub
008151106s2015 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:132193794
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1111312 URI
0247 a https://doi.org/10.1002/ijc.294462 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1321937942 URI
040 a (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Barrdahl, Myrto4 aut
2451 0a Association of breast cancer risk loci with breast cancer survival
264 c 2015-08-14
264 1b Wiley-Blackwell,c 2015
338 a print2 rdacarrier
520 a The survival of breast cancer patients is largely influenced by tumor characteristics, such as TNM stage, tumor grade and hormone receptor status. However, there is growing evidence that inherited genetic variation might affect the disease prognosis and response to treatment. Several lines of evidence suggest that alleles influencing breast cancer risk might also be associated with breast cancer survival. We examined the associations between 35 breast cancer susceptibility loci and the disease over-all survival (OS) in 10,255 breast cancer patients from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3) of which 1,379 died, including 754 of breast cancer. We also conducted a meta-analysis of almost 35,000 patients and 5,000 deaths, combining results from BPC3 and the Breast Cancer Association Consortium (BCAC) and performed in silico analyses of SNPs with significant associations. In BPC3, the C allele of LSP1-rs3817198 was significantly associated with improved OS (HRper-allele=0.70; 95% CI: 0.58-0.85; ptrend=2.84 x 10-4; HRheterozygotes=0.71; 95% CI: 0.55-0.92; HRhomozygotes=0.48; 95% CI: 0.31-0.76; p2DF=1.45 x 10-3). In silico, the C allele of LSP1-rs3817198 was predicted to increase expression of the tumor suppressor cyclin-dependent kinase inhibitor 1C (CDKN1C). In the meta-analysis, TNRC9-rs3803662 was significantly associated with increased death hazard (HRMETA =1.09; 95% CI: 1.04-1.15; ptrend=6.6 x 10-4; HRheterozygotes=0.96 95% CI: 0.90-1.03; HRhomozygotes=1.21; 95% CI: 1.09-1.35; p2DF=1.25 x 10-4). In conclusion, we show that there is little overlap between the breast cancer risk single nucleotide polymorphisms (SNPs) identified so far and the SNPs associated with breast cancer prognosis, with the possible exceptions of LSP1-rs3817198 and TNRC9-rs3803662.What's new? Genetic factors are known to influence the risk of breast cancer, but inherited genetic variation may also affect disease prognosis and response to treatment. In this study, the we investigated whether single nucleotide polymorphisms (SNPs) that are known to be associated with breast cancer risk might also influence the survival of breast-cancer patients. While two of the investigated SNPs may influence survival, there was otherwise no indication that SNP alleles related to breast cancer risk also play a role in the survival of breast cancer patients.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a breast cancer
653 a SNP
653 a survival
653 a BPC3
653 a meta-analysis
7001 a Canzian, Federico4 aut
7001 a Lindström, Sara4 aut
7001 a Shui, Irene4 aut
7001 a Black, Amanda4 aut
7001 a Hoover, Robert N4 aut
7001 a Ziegler, Regina G4 aut
7001 a Buring, Julie E4 aut
7001 a Chanock, Stephen J4 aut
7001 a Diver, W Ryan4 aut
7001 a Gapstur, Susan M4 aut
7001 a Gaudet, Mia M4 aut
7001 a Giles, Graham G4 aut
7001 a Haiman, Christopher4 aut
7001 a Henderson, Brian E4 aut
7001 a Hankinson, Susan4 aut
7001 a Hunter, David J4 aut
7001 a Joshi, Amit D4 aut
7001 a Kraft, Peter4 aut
7001 a Lee, I-Min4 aut
7001 a Le Marchand, Loic4 aut
7001 a Milne, Roger L4 aut
7001 a Southey, Melissa C4 aut
7001 a Willett, Walter4 aut
7001 a Gunter, Marc4 aut
7001 a Panico, Salvatore4 aut
7001 a Sund, Malinu Umeå universitet,Kirurgi4 aut0 (Swepub:umu)masu0021
7001 a Weiderpass, Elisabeteu Karolinska Institutet4 aut
7001 a Sánchez, María-José4 aut
7001 a Overvad, Kim4 aut
7001 a Dossus, Laure4 aut
7001 a Peeters, Petra H4 aut
7001 a Khaw, Kay-Tee4 aut
7001 a Trichopoulos, Dimitrios4 aut
7001 a Kaaks, Rudolf4 aut
7001 a Campa, Daniele4 aut
7102 a Umeå universitetb Kirurgi4 org
7730 t International Journal of Cancerd : Wiley-Blackwellg 137:12, s. 2837-2845q 137:12<2837-2845x 0020-7136x 1097-0215
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.29446
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-111131
8564 8u https://doi.org/10.1002/ijc.29446
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:132193794

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy