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Sökning: ((L773:1460 2156) pers:(Palmqvist Sebastian)) > Early stages of tau...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007563naa a2200577 4500
001oai:lup.lub.lu.se:1144f001-c413-4f2d-bcf0-698964cd9d74
003SwePub
008220208s2021 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:148474830
0247 a https://lup.lub.lu.se/record/1144f001-c413-4f2d-bcf0-698964cd9d742 URI
0247 a https://doi.org/10.1093/brain/awab1142 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1484748302 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Berron, Davidu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)da1401be
2451 0a Early stages of tau pathology and its associations with functional connectivity, atrophy and memory
264 c 2021-03-16
264 1b Oxford University Press (OUP),c 2021
300 a 13 s.
520 a In Alzheimer's disease, post-mortem studies have shown that the first cortical site where neurofibrillary tangles appear is the transentorhinal region, a subregion within the medial temporal lobe that largely overlaps with Brodmann area 35, and the entorhinal cortex. Here we used tau-PET imaging to investigate the sequence of tau pathology progression within the human medial temporal lobe and across regions in the posterior-medial system. Our objective was to study how medial temporal tau is related to functional connectivity, regional atrophy, and memory performance. We included 215 amyloid-β- cognitively unimpaired, 81 amyloid-β+ cognitively unimpaired and 87 amyloid-β+ individuals with mild cognitive impairment, who each underwent 18F-RO948 tau and 18F-flutemetamol amyloid PET imaging, structural T1-MRI and memory assessments as part of the Swedish BioFINDER-2 study. First, event-based modelling revealed that the entorhinal cortex and Brodmann area 35 show the earliest signs of tau accumulation followed by the anterior and posterior hippocampus, Brodmann area 36 and the parahippocampal cortex. In later stages, tau accumulation became abnormal in neocortical temporal and finally parietal brain regions. Second, in cognitively unimpaired individuals, increased tau load was related to local atrophy in the entorhinal cortex, Brodmann area 35 and the anterior hippocampus and tau load in several anterior medial temporal lobe subregions was associated with distant atrophy of the posterior hippocampus. Tau load, but not atrophy, in these regions was associated with lower memory performance. Further, tau-related reductions in functional connectivity in critical networks between the medial temporal lobe and regions in the posterior-medial system were associated with this early memory impairment. Finally, in patients with mild cognitive impairment, the association of tau load in the hippocampus with memory performance was partially mediated by posterior hippocampal atrophy. In summary, our findings highlight the progression of tau pathology across medial temporal lobe subregions and its disease stage-specific association with memory performance. While tau pathology might affect memory performance in cognitively unimpaired individuals via reduced functional connectivity in critical medial temporal lobe-cortical networks, memory impairment in mild cognitively impaired patients is associated with posterior hippocampal atrophy.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653 a Alzheimer's disease
653 a medial temporal lobe subregions
653 a memory
653 a MRI
653 a tau-PET imaging
7001 a Vogel, Jacob W.u University of Pennsylvania4 aut0 (Swepub:lu)ja8870vo
7001 a Insel, Philip S.u Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,University of California, San Francisco4 aut0 (Swepub:lu)med-ppi
7001 a Pereira, Joana B.u Karolinska Institutet,Karolinska Institute4 aut
7001 a Xie, Longu University of Pennsylvania,Hospital of the University of Pennsylvania4 aut
7001 a Wisse, Laura E.M.u Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Hospital of the University of Pennsylvania,University of Pennsylvania4 aut0 (Swepub:lu)la3343wi
7001 a Yushkevich, Paul A.u Hospital of the University of Pennsylvania,University of Pennsylvania4 aut
7001 a Palmqvist, Sebastianu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-spa
7001 a Mattsson-Carlgren, Niklasu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Brain Injury After Cardiac Arrest,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Clinical Memory Research,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)med-nmn
7001 a Stomrud, Eriku Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-esr
7001 a Smith, Rubenu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Regeneration in Movement Disorders,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)mphy-rsm
7001 a Strandberg, Olofu Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,MR Physics,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)teor-osn
7001 a Hansson, Oskaru Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,University of Pennsylvania4 aut0 (Swepub:lu)mphy-ohn
7102 a Klinisk minnesforskningb Forskargrupper vid Lunds universitet4 org
7730 t Braind : Oxford University Press (OUP)g 144:9, s. 2771-2783q 144:9<2771-2783x 0006-8950x 1460-2156
8564 u http://dx.doi.org/10.1093/brain/awab114x freey FULLTEXT
8564 u https://academic.oup.com/brain/advance-article-pdf/doi/10.1093/brain/awab114/40323599/awab114.pdf
8564 8u https://lup.lub.lu.se/record/1144f001-c413-4f2d-bcf0-698964cd9d74
8564 8u https://doi.org/10.1093/brain/awab114
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:148474830

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