Search: ((WFRF:(Stirrups Kathleen)) srt2:(2013) pers:(Wareham Nicholas J) mspu:(article) pers:(Salomaa Veikko)) >
Common variants ass...
Common variants associated with plasma triglycerides and risk for coronary artery disease
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Do, Ron (author)
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Willer, Cristen J. (author)
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Schmidt, Ellen M. (author)
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show more...
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Sengupta, Sebanti (author)
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Gao, Chi (author)
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Peloso, Gina M. (author)
-
- Gustafsson, Stefan (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
-
Kanoni, Stavroula (author)
-
- Ganna, Andrea (author)
- Karolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
-
Chen, Jin (author)
-
- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
-
Mora, Samia (author)
-
Beckmann, Jacques S. (author)
-
Bragg-Gresham, Jennifer L. (author)
-
Chang, Hsing-Yi (author)
-
Demirkan, Ayse (author)
-
Den Hertog, Heleen M. (author)
-
Donnelly, Louise A. (author)
-
Ehret, Georg B. (author)
-
Esko, Tonu (author)
-
Feitosa, Mary F. (author)
-
Ferreira, Teresa (author)
-
Fischer, Krista (author)
-
Fontanillas, Pierre (author)
-
Fraser, Ross M. (author)
-
Freitag, Daniel F. (author)
-
Gurdasani, Deepti (author)
-
Heikkila, Kauko (author)
-
Hyppoenen, Elina (author)
-
Isaacs, Aaron (author)
-
Jackson, Anne U. (author)
-
- Johansson, Åsa (author)
- Uppsala universitet,Genomik,Uppsala kliniska forskningscentrum (UCR)
-
Johnson, Toby (author)
-
Kaakinen, Marika (author)
-
Kettunen, Johannes (author)
-
Kleber, Marcus E. (author)
-
Li, Xiaohui (author)
-
Luan, Jian'an (author)
-
Lyytikainen, Leo-Pekka (author)
-
- Magnusson, Patrik K. E. (author)
- Karolinska Institutet
-
Mangino, Massimo (author)
-
Mihailov, Evelin (author)
-
Montasser, May E. (author)
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Mueller-Nurasyid, Martina (author)
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Nolte, Ilja M. (author)
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O'Connell, Jeffrey R. (author)
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Palmer, Cameron D. (author)
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Perola, Markus (author)
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Petersen, Ann-Kristin (author)
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Sanna, Serena (author)
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Saxena, Richa (author)
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Service, Susan K. (author)
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Shah, Sonia (author)
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- Shungin, Dmitry (author)
- Umeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Medicin,Institutionen för odontologi
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Sidore, Carlo (author)
-
- Song, Ci (author)
- Karolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
-
- Strawbridge, Rona J. (author)
- Karolinska Institutet
-
Surakka, Ida (author)
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Tanaka, Toshiko (author)
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Teslovich, Tanya M. (author)
-
Thorleifsson, Gudmar (author)
-
Van den Herik, Evita G. (author)
-
Voight, Benjamin F. (author)
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Volcik, Kelly A. (author)
-
Waite, Lindsay L. (author)
-
Wong, Andrew (author)
-
Wu, Ying (author)
-
Zhang, Weihua (author)
-
Absher, Devin (author)
-
Asiki, Gershim (author)
-
Barroso, Ines (author)
-
Been, Latonya F. (author)
-
Bolton, Jennifer L. (author)
-
Bonnycastle, Lori L. (author)
-
Brambilla, Paolo (author)
-
Burnett, Mary S. (author)
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Cesana, Giancarlo (author)
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Dimitriou, Maria (author)
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Doney, Alex S. F. (author)
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Doering, Angela (author)
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Elliott, Paul (author)
-
Epstein, Stephen E. (author)
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Eyjolfsson, Gudmundur Ingi (author)
-
- Gigante, Bruna (author)
- Karolinska Institutet
-
Goodarzi, Mark O. (author)
-
Grallert, Harald (author)
-
Gravito, Martha L. (author)
-
Groves, Christopher J. (author)
-
- Hallmans, Göran (author)
- Umeå universitet,Näringsforskning
-
Hartikainen, Anna-Liisa (author)
-
Hayward, Caroline (author)
-
Hernandez, Dena (author)
-
Hicks, Andrew A. (author)
-
Holm, Hilma (author)
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Hung, Yi-Jen (author)
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Illig, Thomas (author)
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Jones, Michelle R. (author)
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Kaleebu, Pontiano (author)
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Kastelein, John J. P. (author)
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Khaw, Kay-Tee (author)
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Kim, Eric (author)
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Klopp, Norman (author)
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Komulainen, Pirjo (author)
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Kumari, Meena (author)
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Langenberg, Claudia (author)
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Lehtimaki, Terho (author)
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Lin, Shih-Yi (author)
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Lindstrom, Jaana (author)
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Loos, Ruth J. F. (author)
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Mach, Francois (author)
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McArdle, Wendy L. (author)
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Meisinger, Christa (author)
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Mitchell, Braxton D. (author)
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Mueller, Gabrielle (author)
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Nagaraja, Ramaiah (author)
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- Narisu, Narisu (author)
- Karolinska Institutet
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Nieminen, Tuomo V. M. (author)
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Nsubuga, Rebecca N. (author)
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Olafsson, Isleifur (author)
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Ong, Ken K. (author)
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Palotie, Aarno (author)
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Papamarkou, Theodore (author)
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Pomilla, Cristina (author)
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Pouta, Anneli (author)
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Rader, Daniel J. (author)
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Reilly, Muredach P. (author)
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Ridker, Paul M. (author)
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Rivadeneira, Fernando (author)
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Rudan, Igor (author)
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Ruokonen, Aimo (author)
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Samani, Nilesh (author)
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Scharnagl, Hubert (author)
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Seeley, Janet (author)
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Silander, Kaisa (author)
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Stancakova, Alena (author)
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Stirrups, Kathleen (author)
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Swift, Amy J. (author)
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Tiret, Laurence (author)
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Uitterlinden, Andre G. (author)
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van Pelt, L. Joost (author)
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Vedantam, Sailaja (author)
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Wainwright, Nicholas (author)
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Wijmenga, Cisca (author)
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Wild, Sarah H. (author)
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Willemsen, Gonneke (author)
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Wilsgaard, Tom (author)
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Wilson, James F. (author)
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Young, Elizabeth H. (author)
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Zhao, Jing Hua (author)
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Adair, Linda S. (author)
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Arveiler, Dominique (author)
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Assimes, Themistocles L. (author)
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Bandinelli, Stefania (author)
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Bennett, Franklyn (author)
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Bochud, Murielle (author)
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Boehm, Bernhard O. (author)
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Boomsma, Dorret I. (author)
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Borecki, Ingrid B. (author)
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Bornstein, Stefan R. (author)
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Bovet, Pascal (author)
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Burnier, Michel (author)
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Campbell, Harry (author)
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Chakravarti, Aravinda (author)
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Chambers, John C. (author)
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Chen, Yii-Der Ida (author)
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Collins, Francis S. (author)
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Cooper, Richard S. (author)
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Danesh, John (author)
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Dedoussis, George (author)
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- de Faire, Ulf (author)
- Karolinska Institutet
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Feranil, Alan B. (author)
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Ferrieres, Jean (author)
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Ferrucci, Luigi (author)
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Freimer, Nelson B. (author)
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Gieger, Christian (author)
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Gudnason, Vilmundur (author)
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- Gyllensten, Ulf (author)
- Uppsala universitet,Genomik,Uppsala kliniska forskningscentrum (UCR)
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- Hamsten, Anders (author)
- Karolinska Institutet
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Harris, Tamara B. (author)
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Hingorani, Aroon (author)
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Hirschhorn, Joel N. (author)
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Hofman, Albert (author)
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Hovingh, G. Kees (author)
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Hsiung, Chao Agnes (author)
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Humphries, Steve E. (author)
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Hunt, Steven C. (author)
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Hveem, Kristian (author)
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Iribarren, Carlos (author)
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Jarvelin, Marjo-Riitta (author)
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Jula, Antti (author)
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Kahonen, Mika (author)
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Kaprio, Jaakko (author)
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Kesaniemi, Antero (author)
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Kivimaki, Mika (author)
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Kooner, Jaspal S. (author)
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Koudstaal, Peter J. (author)
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Krauss, Ronald M. (author)
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Kuh, Diana (author)
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Kuusisto, Johanna (author)
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Kyvik, Kirsten O. (author)
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Laakso, Markku (author)
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Lakka, Timo A. (author)
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- Lind, Lars (author)
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Lindgren, Cecilia M. (author)
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Martin, Nicholas G. (author)
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Maerz, Winfried (author)
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McCarthy, Mark I. (author)
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McKenzie, Colin A. (author)
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Meneton, Pierre (author)
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Metspalu, Andres (author)
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Moilanen, Leena (author)
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Morris, Andrew D. (author)
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Munroe, Patricia B. (author)
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Njolstad, Inger (author)
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Pedersen, Nancy L. (author)
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Power, Chris (author)
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Pramstaller, Peter P. (author)
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Price, Jackie F. (author)
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Psaty, Bruce M. (author)
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Quertermous, Thomas (author)
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Rauramaa, Rainer (author)
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Saleheen, Danish (author)
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Salomaa, Veikko (author)
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Sanghera, Dharambir K. (author)
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Saramies, Jouko (author)
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Schwarz, Peter E. H. (author)
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Sheu, Wayne H-H (author)
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Shuldiner, Alan R. (author)
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- Siegbahn, Agneta (author)
- Uppsala universitet,Molekylär epidemiologi,Uppsala kliniska forskningscentrum (UCR),Koagulation och inflammationsvetenskap
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Spector, Tim D. (author)
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Stefansson, Kari (author)
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Strachan, David P. (author)
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Tayo, Bamidele O. (author)
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Tremoli, Elena (author)
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Tuomilehto, Jaakko (author)
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Uusitupa, Matti (author)
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van Duijn, Cornelia M. (author)
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Vollenweider, Peter (author)
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- Wallentin, Lars (author)
- Uppsala universitet,Kardiologi
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Wareham, Nicholas J. (author)
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Whitfield, John B. (author)
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Wolffenbuttel, Bruce H. R. (author)
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Altshuler, David (author)
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Ordovas, Jose M. (author)
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Boerwinkle, Eric (author)
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Palmer, Colin N. A. (author)
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Thorsteinsdottir, Unnur (author)
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Chasman, Daniel I. (author)
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Rotter, Jerome I. (author)
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- Franks, Paul (author)
- Umeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Medicin,Lunds universitet, Harvard University
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Ripatti, Samuli (author)
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Cupples, L. Adrienne (author)
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Sandhu, Manjinder S. (author)
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Rich, Stephen S. (author)
-
Boehnke, Michael (author)
-
Deloukas, Panos (author)
-
Mohlke, Karen L. (author)
-
- Ingelsson, Erik (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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Abecasis, Goncalo R. (author)
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Daly, Mark J. (author)
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Neale, Benjamin M. (author)
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Kathiresan, Sekar (author)
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(creator_code:org_t)
- 2013-10-06
- 2013
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:11, s. 1345-
- Related links:
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Abstract
Subject headings
Close
- Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 x 10(-8) for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- ref (subject category)
- art (subject category)
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Do, Ron
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Willer, Cristen ...
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Bragg-Gresham, J ...
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Chang, Hsing-Yi
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Demirkan, Ayse
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Den Hertog, Hele ...
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Donnelly, Louise ...
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Ehret, Georg B.
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Kaakinen, Marika
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Li, Xiaohui
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Shungin, Dmitry
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Song, Ci
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Tanaka, Toshiko
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Wong, Andrew
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Wu, Ying
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Zhang, Weihua
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Absher, Devin
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Asiki, Gershim
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Barroso, Ines
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Been, Latonya F.
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Bolton, Jennifer ...
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Bonnycastle, Lor ...
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Brambilla, Paolo
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Burnett, Mary S.
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Cesana, Giancarl ...
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Dimitriou, Maria
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Doney, Alex S. F ...
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Doering, Angela
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Elliott, Paul
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Epstein, Stephen ...
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Eyjolfsson, Gudm ...
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Gigante, Bruna
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Goodarzi, Mark O ...
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Grallert, Harald
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Lindstrom, Jaana
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Loos, Ruth J. F.
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Meisinger, Chris ...
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Swift, Amy J.
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Wilsgaard, Tom
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Wilson, James F.
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Zhao, Jing Hua
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Arveiler, Domini ...
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Chambers, John C ...
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Collins, Francis ...
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Cooper, Richard ...
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Danesh, John
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Dedoussis, Georg ...
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Nature Genetics
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Uppsala University
-
Lund University
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Karolinska Institutet
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Umeå University