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Final height after ...
Final height after combined growth hormone and GnRH analogue treatment in adopted girls with early puberty
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- Tuvemo, Torsten (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forskning/Tuvemo,Kvinnors och barns hälsa Uppsala
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- Jonsson, Björn (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forskning/Tuvemo,Kvinnors och barns hälsa Uppsala
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- Gustafsson, Jan (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forskning/Tuvemo,Kvinnors och barns hälsa Uppsala
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- Albertsson-Wikland, Kerstin, 1947 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics,Sahlgrenska sjukhuset Göteborg
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- Aronson, AS (author)
- Sahlgrenska sjukhuset Göteborg
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- Häger, Anders, 1939- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Pediatrik,Barn- och ungdomskliniken i Linköping
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- Ivarsson, Sten (author)
- Barnkliniken Malmö
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- Kriström, Berit (author)
- Gothenburg University,Göteborgs universitet,Umeå universitet,Pediatrik,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics,Barnkliniken Malmö
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- Marcus, Claude (author)
- Karolinska Institutet,Huddinge sjukhus Huddinge
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- Nilsson, Karl-Olof (author)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Barnkliniken Malmö
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- Westgren, U (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics,Sahlgrenska sjukhuset Göteborg
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- Westphal, Otto, 1935 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics,Sahlgrenska sjukhuset Göteborg
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- Åman, Jan (author)
- Barnkliniken Örebro,Barnendokrinologisk forskning/Tuvemo
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- Proos, Lemm (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forskning/Tuvemo,Kvinnors och barns hälsa Uppsala
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(creator_code:org_t)
- Wiley, 2004
- 2004
- English.
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In: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 93:11, s. 1456-1462
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
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- Background: Girls adopted from developing countries often have early or precocious puberty, requiring treatment with gonadotrophin-releasing hormone (GnRH) analogues. During such treatment, decreased growth velocity is frequent. Aim: To study whether the addition of growth hormone (GH) to GnRH analogue treatment improves final height in girls with early or precocious puberty. Methods: Forty-six girls with early or precocious puberty (age ≤9.5 y) adopted from developing countries were randomized for treatment for 2-4 y with GnRH analogue, or with a combination of GH and GnRH analogue. Results: During treatment, the mean growth velocity in the GH/GnRH analogue group was significantly higher compared to the control group. Combined GH/GnRH analogue treatment resulted in a higher final height: 158.9 cm compared to 155.8 cm in the GnRH analogue-treated group. Three out of 24 girls (13%) in the combined group and nine of the 22 girls (41%) treated with GnRH analogue alone attained a final height below -2 standard deviation scores (SDS). Conclusion: The difference between the two groups is statistically significant, and possibly of clinical importance. A future challenge is to identify a subgroup with clinically significant advantage of GH addition to GnRH analogue treatment. Being very short on arrival in Sweden and being short and young at start of treatment are possible indicators.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- Puberty
- precocious
- GnRH analogue
- growth hormone
- girls
- controlled clinical trial
- MEDICINE
- MEDICIN
- clinical trial
- controlled
- girls
- growth hormone
- GnRH analogue
- puberty
- precocious
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Tuvemo, Torsten
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Jonsson, Björn
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Gustafsson, Jan
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Albertsson-Wikla ...
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Aronson, AS
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Häger, Anders, 1 ...
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show more...
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Ivarsson, Sten
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Kriström, Berit
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Marcus, Claude
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Nilsson, Karl-Ol ...
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Westgren, U
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Westphal, Otto, ...
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Åman, Jan
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Proos, Lemm
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
- Articles in the publication
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Acta Paediatrica
- By the university
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Linköping University
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Umeå University
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Uppsala University
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Karolinska Institutet
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Lund University
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University of Gothenburg