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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003475naa a2200385 4500
001oai:lup.lub.lu.se:f2f7d913-9335-4b27-ad7a-05ab9052952c
003SwePub
008160401s2004 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/11292162 URI
0247 a https://doi.org/10.1186/1476-4598-3-62 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Diep, Chieu B4 aut
2451 0a Genome characteristics of primary carcinomas, local recurrences, carcinomatoses, and liver metastases from colorectal cancer patients
264 1b Springer Science and Business Media LLC,c 2004
520 a BACKGROUND: Colorectal cancer (CRC) is one of the most common causes of cancer-related deaths in the Western world, and despite the fact that metastases are usually the ultimate cause of deaths, the knowledge of the genetics of advanced stages of this disease is limited. In order to identify potential genetic abnormalities underlying the development of local and distant metastases in CRC patients, we have, by comparative genomic hybridization, compared the DNA copy number profiles of 10 primary carcinomas, 14 local recurrences, 7 peritoneal carcinomatoses, and 42 liver metastases from 61 CRC patients. RESULTS: The median number of aberrations among the primary carcinomas, local recurrences, carcinomatoses, and liver metastases was 10, 6, 13, and 14, respectively. Several genetic imbalances, such as gains of 7, 8q, 13q, and 20, and losses of 4q, 8p, 17p, and 18, were common in all groups. In contrast, gains of 5p and 12p were more common in the carcinomatoses than in other stages of the disease. With hierarchical cluster analysis, liver metastases could be divided into two main subgroups according to clusters of chromosome changes. CONCLUSIONS: Each stage of CRC progression is characterized by a particular genetic profile, and both carcinomatoses and liver metastases are more genetically complex than local recurrences and primary carcinomas. This is the first genome profiling of local recurrences and carcinomatoses, and gains of 5p and 12p seem to be particularly important for the spread of the CRC cells within the peritoneal cavity.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Teixeira, Manuel R4 aut
7001 a Thorstensen, Lin4 aut
7001 a Wiig, Johan N4 aut
7001 a Eknaes, Mette4 aut
7001 a Nesland, Jahn M4 aut
7001 a Giercksky, Karl-Erik4 aut
7001 a Johansson, Bertilu Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kgen-bjo
7001 a Lothe, Ragnhild A4 aut
7102 a Avdelningen för klinisk genetikb Institutionen för laboratoriemedicin4 org
7730 t Molecular Cancerd : Springer Science and Business Media LLCg 3q 3x 1476-4598
8564 u http://dx.doi.org/10.1186/1476-4598-3-6x freey FULLTEXT
8564 u https://molecular-cancer.biomedcentral.com/track/pdf/10.1186/1476-4598-3-6
8564 8u https://lup.lub.lu.se/record/1129216
8564 8u https://doi.org/10.1186/1476-4598-3-6

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