Search: (WFRF:(Åkerman Eva)) srt2:(2005-2009) >
CD40 expression ide...
CD40 expression identifies a prognostically favourable subgroup of diffuse large B-cell lymphoma
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- Linderoth, Johan (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Bröstcancer-genetik,Institutionen för kliniska vetenskaper, Lund,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Breastcancer-genetics,Department of Clinical Sciences, Lund
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- Ehinger, Mats (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Jerkeman, Mats (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Bröstcancer-genetik,Institutionen för kliniska vetenskaper, Lund,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Breastcancer-genetics,Department of Clinical Sciences, Lund
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- Bendahl, Pär-Ola (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Åkerman, Måns (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Berglund, Mattias (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Lymfomgruppen
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- Enblad, Gunilla (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Lymfomgruppen
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- Erlanson, Martin (author)
- Umeå universitet,Onkologi
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- Roos, Göran (author)
- Umeå universitet,Patologi
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- Cavallin-Ståhl, Eva (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Bröstcancer-genetik,Institutionen för kliniska vetenskaper, Lund,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Breastcancer-genetics,Department of Clinical Sciences, Lund
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(creator_code:org_t)
- 2009-07
- 2007
- English.
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In: Leukemia and Lymphoma. - : Informa UK Limited. - 1042-8194 .- 1029-2403. ; 48:9, s. 1774-1779
- Related links:
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http://www.ncbi.nlm....
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- In order to confirm our earlier findings of the prognostic effects of CD23 and CD40 expression in diffuse large B-cell lymphoma (DLBCL), possibly due to association with the germinal center (GC) phenotype and/or an increased autologous tumour response, tumour specimens from 125 patients with de novo DLBCL were investigated for immunohistochemical expression of CD23, CD40, BCL6, CD10, MUM1, CD4 and CD8. CD40 was positive in 64% and was associated with improved overall survival (p = 0.03). A GC phenotype was present in 47%, and was also associated with a better overall survival (p = 0.006) but did not correlate with CD40-expression. There was no correlation between amount of tumour infiltrating T-cells and CD40-positivity. CD23 was positive in 10% and expression did not correlate with prognosis. In conclusion, the prognostic effect of CD40 expression was confirmed, but did not correlate with GC-phenotype or T-cell infiltration.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Adolescent
- Adult
- Aged
- Aged; 80 and over
- Antigens; CD40/*analysis
- Female
- Humans
- Immunohistochemistry
- Lymphoma; B-Cell/metabolism/*mortality
- Male
- Middle Aged
- Prognosis
- MEDICINE
- MEDICIN
- DLBCL
- CD40
- prognosis
- GC-phenotype
- CD4
- CD8
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Linderoth, Johan
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Ehinger, Mats
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Jerkeman, Mats
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Bendahl, Pär-Ola
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Åkerman, Måns
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Berglund, Mattia ...
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show more...
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Enblad, Gunilla
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Erlanson, Martin
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Roos, Göran
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Cavallin-Ståhl, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Leukemia and Lym ...
- By the university
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Uppsala University
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Umeå University
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Lund University