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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03497naa a2200421 4500 | |
| 001 | oai:DiVA.org:umu-182014 | |
| 003 | SwePub | |
| 008 | 210406s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1820142 URI |
| 024 | 7 | a https://doi.org/10.3389/fendo.2021.6330632 DOI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a for2 swepub-publicationtype |
| 100 | 1 | a Alanentalo, Tomasu Umeå universitet,Umeå centrum för molekylär medicin (UCMM)4 aut0 (Swepub:umu)tosalo98 |
| 245 | 1 0 | a Mesoscopic Optical Imaging of the Pancreas :b Revisiting Pancreatic Anatomy and Pathophysiology |
| 264 | c 2021-03-04 | |
| 264 | 1 | b Frontiers Media S.A.c 2021 |
| 338 | a electronic2 rdacarrier | |
| 520 | a The exocrine-endocrine multipart organization of the pancreas makes it an exceedingly challenging organ to analyze, quantitatively and spatially. Both in rodents and humans, estimates of the pancreatic cellular composition, including beta-cell mass, has been largely relying on the extrapolation of 2D stereological data originating from limited sample volumes. Alternatively, they have been obtained by low resolution non-invasive imaging techniques providing little detail regarding the anatomical organization of the pancreas and its cellular and/or molecular make up. In this mini-review, the state of the art and the future potential of currently existing and emerging high-resolution optical imaging techniques working in the mm-cm range with μm resolution, here referred to as mesoscopic imaging approaches, will be discussed regarding their contribution toward a better understanding of pancreatic anatomy both in normal conditions and in the diabetic setting. In particular, optical projection tomography (OPT) and light sheet fluorescence microscopy (LSFM) imaging of the pancreas and their associated tissue processing and computational analysis protocols will be discussed in the light of their current capabilities and future potential to obtain more detailed 3D-spatial, quantitative, and molecular information of the pancreas. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 653 | a diabetes | |
| 653 | a light sheet fluorescence microscopy | |
| 653 | a mesoscopic imaging | |
| 653 | a optical projection tomography | |
| 653 | a pancreas | |
| 700 | 1 | a Hahn, Maxu Umeå universitet,Umeå centrum för molekylär medicin (UCMM)4 aut0 (Swepub:umu)maha5788 |
| 700 | 1 | a Willekens, Stefanie M. A.u Umeå universitet,Umeå centrum för molekylär medicin (UCMM)4 aut0 (Swepub:umu)stbe0129 |
| 700 | 1 | a Ahlgren, Ulfu Umeå universitet,Umeå centrum för molekylär medicin (UCMM)4 aut0 (Swepub:umu)ulah0001 |
| 710 | 2 | a Umeå universitetb Umeå centrum för molekylär medicin (UCMM)4 org |
| 773 | 0 | t Frontiers in Endocrinologyd : Frontiers Media S.A.g 12q 12x 1664-2392 |
| 856 | 4 | u https://doi.org/10.3389/fendo.2021.633063y Fulltext |
| 856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1542008/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://www.frontiersin.org/articles/10.3389/fendo.2021.633063/pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-182014 |
| 856 | 4 8 | u https://doi.org/10.3389/fendo.2021.633063 |
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