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FältnamnIndikatorerMetadata
00006638naa a2200481 4500
001oai:lup.lub.lu.se:505f2246-cdac-4257-b7cd-53de77a30016
003SwePub
008160401s2013 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-223013
0247 a https://lup.lub.lu.se/record/36284542 URI
0247 a https://doi.org/10.1111/pedi.120232 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2230132 URI
040 a (SwePub)lud (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Andersson, Cecilia Ku Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Department of Clinical Sciences, Lund University/CRC, Skåne University Hospital SUS, Malmö, Sweden4 aut0 (Swepub:uu)laper499
2451 0a Glucose tolerance and beta-cell function in islet autoantibody-positive children recruited to a secondary prevention study.
264 c 2013-03-08
264 1b Hindawi Limited,c 2013
520 a AIMS: Children with type 1 diabetes (T1D) risk and islet autoantibodies are recruited to a secondary prevention study. The aims were to determine metabolic control in relation to human leukocyte antigen (HLA) genetic risk and islet autoantibodies in prepubertal children. METHODS: In 47 healthy children with GADA and at least one additional islet autoantibody, intravenous glucose tolerance test (IvGTT) and oral glucose tolerance test (OGTT) were performed 8-65 d apart. Hemoglobin A1c, plasma glucose as well as serum insulin and C-peptide were determined at fasting and during IvGTT and OGTT. RESULTS: All children aged median 5.1 (4.0-9.2) yr had autoantibodies to two to six of the beta-cell antigens GAD65, insulin, IA-2, and the three amino acid position 325 variants of the ZnT8 transporter. In total, 20/47 children showed impaired glucose metabolism. Decreased (≤30 μU/mL insulin) first-phase insulin response (FPIR) was found in 14/20 children while 11/20 had impaired glucose tolerance in the OGTT. Five children had both impaired glucose tolerance and FPIR ≤30 μU/mL insulin. Number and levels of autoantibodies were not associated with glucose metabolism, except for an increased frequency (p = 0.03) and level (p = 0.01) of ZnT8QA in children with impaired glucose metabolism. Among the children with impaired glucose metabolism, 13/20 had HLA-DQ2/8, compared to 9/27 of the children with normal glucose metabolism (p = 0.03). CONCLUSION: Secondary prevention studies in children with islet autoantibodies are complicated by variability in baseline glucose metabolism. Evaluation of metabolic control with both IvGTT and OGTT is critical and should be taken into account before randomization. All currently available autoantibody tests should be analyzed, including ZnT8QA.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng
7001 a Carlsson, Annelieu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Paediatrics, Lund University, Skåne University Hospital SUS, Lund, Sweden4 aut0 (Swepub:lu)med-acs
7001 a Cilio, Corradou Lund University,Lunds universitet,Diabetes - immunovirologi,Forskargrupper vid Lunds universitet,Diabetes - Immunovirology,Lund University Research Groups,Department of Clinical Sciences, Lund University/CRC, Skåne University Hospital SUS, Malmö, Sweden4 aut0 (Swepub:lu)endo-cci
7001 a Cedervall, Elisabethu Department of Paediatrics, Helsingborg Hospital, Helsingborg, Sweden4 aut
7001 a Ivarsson, Stenu Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Department of Clinical Sciences, Lund University/CRC, Skåne University Hospital SUS, Malmö, Sweden4 aut0 (Swepub:lu)pedi-siv
7001 a Jonsdottir, Berglindu Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Department of Clinical Sciences, Lund University/CRC, Skåne University Hospital SUS, Malmö, Sweden4 aut0 (Swepub:lu)med-bij
7001 a Jönsson, Björnu Department of Paediatrics, Ystad Hospital, Ystad, Sweden4 aut
7001 a Larsson, Karinu Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Department of Paediatrics, Kristianstad Hospital, Kristianstad, Sweden4 aut0 (Swepub:lu)med-kil
7001 a Neiderud, Janu Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Paediatrics, Helsingborg Hospital, Helsingborg, Sweden4 aut0 (Swepub:lu)med-jnu
7001 a Lernmark, Åkeu Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Department of Clinical Sciences, Lund University/CRC, Skåne University Hospital SUS, Malmö, Sweden4 aut0 (Swepub:lu)endo-ale
7001 a Larsson, Helenau Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Department of Clinical Sciences, Lund University/CRC, Skåne University Hospital SUS, Malmö, Sweden4 aut0 (Swepub:lu)pedi-hla
7102 a Pediatrisk endokrinologib Forskargrupper vid Lunds universitet4 org
7730 t Pediatric Diabetesd : Hindawi Limitedg 14:5, s. 341-349q 14:5<341-349x 1399-543Xx 1399-5448
8564 u http://www.ncbi.nlm.nih.gov/pubmed/23469940?dopt=Abstracty FULLTEXT
8564 u http://dx.doi.org/10.1111/pedi.12023y FULLTEXT
8564 8u https://lup.lub.lu.se/record/3628454
8564 8u https://doi.org/10.1111/pedi.12023
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-223013

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