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HER-2/neu amplifica...
HER-2/neu amplification predicts poor survival in node-positive breast cancer
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- Borg, A (author)
- Skåne University Hospital
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- Tandon, A K (author)
- University of Texas Health Science Centre
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- Sigurdsson, H (author)
- Lund University
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- Clark, G M (author)
- University of Texas Health Science Centre
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- Fernö, M (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Individuell Bröstcancerbehandling,Forskargrupper vid Lunds universitet,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Personalized Breast Cancer Treatment,Lund University Research Groups
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- Fuqua, S A (author)
- University of Texas Health Science Centre
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- Killander, D (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- McGuire, W L (author)
- University of Texas Health Science Centre
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(creator_code:org_t)
- 1990
- 1990
- English 6 s.
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In: Cancer Research. - 0008-5472. ; 50:14, s. 7-4332
- Related links:
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https://lup.lub.lu.s...
Abstract
Subject headings
Close
- HER-2/neu protooncogene amplification and protein expression were analyzed with slot blot and Western blot techniques, respectively, in more than 300 invasive primary breast tumors of all stages. Amplification (2- greater than 30 copies) was found in 17% of these tumors and high expression was seen in 19%. There was a striking coincidence between gene amplification and high expression. Tumors associated with many involved axillary lymph nodes or with Stage IV disease were more often HER-2/neu amplified or overexpressed. Furthermore, gene alteration was strongly correlated with the absence of steroid receptors and with larger tumor size. High expression without gene amplification was seen in a minor subset of tumors of less aggressive character. Neither amplification nor overexpression was correlated with disease outcome for patients with negative axillary lymph nodes. For node-positive patients, however, HER-2/neu amplification was a significant predictor of early relapse and death (median follow-up = 45 months), and a similar trend, although not significant, existed for high gene expression. Multivariate analyses indicated that HER-2/neu alterations were not independent predictors of patient outcome.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Amino Acid Sequence
- Biomarkers, Tumor/analysis
- Blotting, Western
- Breast Neoplasms/analysis
- Female
- Gene Amplification
- Gene Expression
- Humans
- Immune Sera
- Lymphatic Metastasis
- Menopause
- Molecular Sequence Data
- Peptides/chemical synthesis
- Prognosis
- Protein-Tyrosine Kinases/genetics
- Proto-Oncogene Proteins/analysis
- Proto-Oncogenes
- Receptor, ErbB-2
- Receptors, Estrogen/analysis
- Receptors, Progesterone
Publication and Content Type
- art (subject category)
- ref (subject category)
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