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Longitudinal associ...
Longitudinal association between hippocampus atrophy and episodic-memory decline in non-demented APOE ε4 carriers
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- Gorbach, Tetiana, 1991- (author)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Pudas, Sara, Fil. Dr. 1983- (author)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)
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Bartrés-Faz, David (author)
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- Brandmaier, Andreas M. (author)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany
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- Düzel, Sandra (author)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany
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- Henson, Richard N. (author)
- MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK
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- Idland, Ane-Victoria (author)
- Oslo Delirium Research Group, Department of Geriatric Medicine, University of Oslo,Oslo, Norway
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- Lindenberger, Ulman (author)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany
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- Macià Bros, Dídac (author)
- Department of Medicine, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain
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- Mowinckel, Athanasia M. (author)
- Center for Lifespan Changes in Brain and Cognition, University of Oslo,Oslo, Norway
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- Solé-Padullés, Cristina (author)
- Department of Medicine, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain
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- Sørensen, Øystein (author)
- Center for Lifespan Changes in Brain and Cognition, University of Oslo,Oslo, Norway
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- Walhovd, Kristine B. (author)
- Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway
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- Watne, Leiv Otto (author)
- MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK
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- Westerhausen, René (author)
- Center for Lifespan Changes in Brain and Cognition, University of Oslo,Oslo, Norway
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- Fjell, Anders M. (author)
- Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway
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- Nyberg, Lars, 1966- (author)
- Umeå universitet,Diagnostisk radiologi,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)
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(creator_code:org_t)
- 2020-09-28
- 2020
- English.
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In: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring. - : John Wiley & Sons. - 2352-8729. ; 12:1
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Abstract
Subject headings
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- Introduction: The apolipoprotein E (APOE) ε4 allele is the main genetic risk factor for Alzheimer's disease (AD), accelerated cognitive aging, and hippocampal atrophy, but its influence on the association between hippocampus atrophy and episodic-memory decline in non-demented individuals remains unclear.Methods: We analyzed longitudinal (two to six observations) magnetic resonance imaging (MRI)–derived hippocampal volumes and episodic memory from 748 individuals (55 to 90 years at baseline, 50% female) from the European Lifebrain consortium.Results: The change-change association for hippocampal volume and memory was significant only in ε4 carriers (N = 173, r = 0.21, P = .007; non-carriers: N = 467, r = 0.073,P = .117). The linear relationship was significantly steeper for the carriers [t(629) =2.4, P = .013]. A similar trend toward a stronger change-change relation for carriers was seen in a subsample with more than two assessments.Discussion: These findings provide evidence for a difference in hippocampus-memory association between ε4 carriers and non-carriers, thus highlighting how genetic factors modulate the translation of the AD-related pathophysiological cascade into cognitive deficits.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- apolipoprotein (APOE) ε4
- hippocampus
- longitudinal
- memory
- MRI
Publication and Content Type
- ref (subject category)
- art (subject category)
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Gorbach, Tetiana ...
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Pudas, Sara, Fil ...
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Bartrés-Faz, Dav ...
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Brandmaier, Andr ...
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Düzel, Sandra
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Henson, Richard ...
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Idland, Ane-Vict ...
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Lindenberger, Ul ...
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Macià Bros, Dída ...
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Mowinckel, Athan ...
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Solé-Padullés, C ...
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Sørensen, Øystei ...
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Walhovd, Kristin ...
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Watne, Leiv Otto
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Westerhausen, Re ...
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Fjell, Anders M.
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Nyberg, Lars, 19 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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Alzheimer’s & De ...
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Umeå University