Sökning: (WFRF:(Davies Melanie J)) pers:(Gudnason Vilmundur) > Genome-wide associa...
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000 | 10813naa a2202965 4500 | |
001 | oai:DiVA.org:uu-196032 | |
003 | SwePub | |
008 | 130304s2013 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1960322 URI |
024 | 7 | a https://doi.org/10.1038/ng.25002 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Koettgen, Anna4 aut |
245 | 1 0 | a Genome-wide association analyses identify 18 new loci associated with serum urate concentrations |
264 | c 2012-12-23 | |
264 | 1 | b Springer Science and Business Media LLC,c 2013 |
338 | a print2 rdacarrier | |
520 | a Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SEMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional excretion of urate. Network analyses implicate the inhibins-activins signaling pathways and glucose metabolism in systemic urate control. New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout. | |
700 | 1 | a Albrecht, Eva4 aut |
700 | 1 | a Teumer, Alexander4 aut |
700 | 1 | a Vitart, Veronique4 aut |
700 | 1 | a Krumsiek, Jan4 aut |
700 | 1 | a Hundertmark, Claudia4 aut |
700 | 1 | a Pistis, Giorgio4 aut |
700 | 1 | a Ruggiero, Daniela4 aut |
700 | 1 | a O'Seaghdha, Conall M.4 aut |
700 | 1 | a Haller, Toomas4 aut |
700 | 1 | a Yang, Qiong4 aut |
700 | 1 | a Tanaka, Toshiko4 aut |
700 | 1 | a Johnson, Andrew D.4 aut |
700 | 1 | a Kutalik, Zoltan4 aut |
700 | 1 | a Smith, Albert V.4 aut |
700 | 1 | a Shi, Julia4 aut |
700 | 1 | a Struchalin, Maksim4 aut |
700 | 1 | a Middelberg, Rita P. S.4 aut |
700 | 1 | a Brown, Morris J.4 aut |
700 | 1 | a Gaffo, Angelo L.4 aut |
700 | 1 | a Pirastu, Nicola4 aut |
700 | 1 | a Li, Guo4 aut |
700 | 1 | a Hayward, Caroline4 aut |
700 | 1 | a Zemunik, Tatijana4 aut |
700 | 1 | a Huffman, Jennifer4 aut |
700 | 1 | a Yengo, Loic4 aut |
700 | 1 | a Zhao, Jing Hua4 aut |
700 | 1 | a Demirkan, Ayse4 aut |
700 | 1 | a Feitosa, Mary F.4 aut |
700 | 1 | a Liu, Xuan4 aut |
700 | 1 | a Malerba, Giovanni4 aut |
700 | 1 | a Lopez, Lorna M.4 aut |
700 | 1 | a van der Harst, Pim4 aut |
700 | 1 | a Li, Xinzhong4 aut |
700 | 1 | a Kleber, Marcus E.4 aut |
700 | 1 | a Hicks, Andrew A.4 aut |
700 | 1 | a Nolte, Ilja M.4 aut |
700 | 1 | a Johansson, Åsau Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Institutionen för immunologi, genetik och patologi4 aut0 (Swepub:uu)asjoh108 |
700 | 1 | a Murgia, Federico4 aut |
700 | 1 | a Wild, Sarah H.4 aut |
700 | 1 | a Bakker, Stephan J. L.4 aut |
700 | 1 | a Peden, John F.4 aut |
700 | 1 | a Dehghan, Abbas4 aut |
700 | 1 | a Steri, Maristella4 aut |
700 | 1 | a Tenesa, Albert4 aut |
700 | 1 | a Lagou, Vasiliki4 aut |
700 | 1 | a Salo, Perttu4 aut |
700 | 1 | a Mangino, Massimo4 aut |
700 | 1 | a Rose, Lynda M.4 aut |
700 | 1 | a Lehtimaki, Terho4 aut |
700 | 1 | a Woodward, Owen M.4 aut |
700 | 1 | a Okada, Yukinori4 aut |
700 | 1 | a Tin, Adrienne4 aut |
700 | 1 | a Mueller, Christian4 aut |
700 | 1 | a Oldmeadow, Christopher4 aut |
700 | 1 | a Putku, Margus4 aut |
700 | 1 | a Czamara, Darina4 aut |
700 | 1 | a Kraft, Peter4 aut |
700 | 1 | a Frogheri, Laura4 aut |
700 | 1 | a Thun, Gian Andri4 aut |
700 | 1 | a Grotevendt, Anne4 aut |
700 | 1 | a Gislason, Gauti Kjartan4 aut |
700 | 1 | a Harris, Tamara B.4 aut |
700 | 1 | a Launer, Lenore J.4 aut |
700 | 1 | a McArdle, Patrick4 aut |
700 | 1 | a Shuldiner, Alan R.4 aut |
700 | 1 | a Boerwinkle, Eric4 aut |
700 | 1 | a Coresh, Josef4 aut |
700 | 1 | a Schmidt, Helena4 aut |
700 | 1 | a Schallert, Michael4 aut |
700 | 1 | a Martin, Nicholas G.4 aut |
700 | 1 | a Montgomery, Grant W.4 aut |
700 | 1 | a Kubo, Michiaki4 aut |
700 | 1 | a Nakamura, Yusuke4 aut |
700 | 1 | a Tanaka, Toshihiro4 aut |
700 | 1 | a Munroe, Patricia B.4 aut |
700 | 1 | a Samani, Nilesh J.4 aut |
700 | 1 | a Jacobs, David R., Jr.4 aut |
700 | 1 | a Liu, Kiang4 aut |
700 | 1 | a D'Adamo, Pio4 aut |
700 | 1 | a Ulivi, Sheila4 aut |
700 | 1 | a Rotter, Jerome I.4 aut |
700 | 1 | a Psaty, Bruce M.4 aut |
700 | 1 | a Vollenweider, Peter4 aut |
700 | 1 | a Waeber, Gerard4 aut |
700 | 1 | a Campbell, Susan4 aut |
700 | 1 | a Devuyst, Olivier4 aut |
700 | 1 | a Navarro, Pau4 aut |
700 | 1 | a Kolcic, Ivana4 aut |
700 | 1 | a Hastie, Nicholas4 aut |
700 | 1 | a Balkau, Beverley4 aut |
700 | 1 | a Froguel, Philippe4 aut |
700 | 1 | a Esko, Tonu4 aut |
700 | 1 | a Salumets, Andres4 aut |
700 | 1 | a Khaw, Kay Tee4 aut |
700 | 1 | a Langenberg, Claudia4 aut |
700 | 1 | a Wareham, Nicholas J.4 aut |
700 | 1 | a Isaacs, Aaron4 aut |
700 | 1 | a Kraja, Aldi4 aut |
700 | 1 | a Zhang, Qunyuan4 aut |
700 | 1 | a Wild, Philipp S.4 aut |
700 | 1 | a Scott, Rodney J.4 aut |
700 | 1 | a Holliday, Elizabeth G.4 aut |
700 | 1 | a Org, Elin4 aut |
700 | 1 | a Viigimaa, Margus4 aut |
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700 | 1 | a Metter, Jeffrey E.4 aut |
700 | 1 | a Lupo, Antonio4 aut |
700 | 1 | a Trabetti, Elisabetta4 aut |
700 | 1 | a Sorice, Rossella4 aut |
700 | 1 | a Doering, Angela4 aut |
700 | 1 | a Lattka, Eva4 aut |
700 | 1 | a Strauch, Konstantin4 aut |
700 | 1 | a Theis, Fabian4 aut |
700 | 1 | a Waldenberger, Melanie4 aut |
700 | 1 | a Wichmann, H-Erich4 aut |
700 | 1 | a Davies, Gail4 aut |
700 | 1 | a Gow, Alan J.4 aut |
700 | 1 | a Bruinenberg, Marcel4 aut |
700 | 1 | a Stolk, Ronald P.4 aut |
700 | 1 | a Kooner, Jaspal S.4 aut |
700 | 1 | a Zhang, Weihua4 aut |
700 | 1 | a Winkelmann, Bernhard R.4 aut |
700 | 1 | a Boehm, Bernhard O.4 aut |
700 | 1 | a Lucae, Susanne4 aut |
700 | 1 | a Penninx, Brenda W.4 aut |
700 | 1 | a Smit, Johannes H.4 aut |
700 | 1 | a Curhan, Gary4 aut |
700 | 1 | a Mudgal, Poorva4 aut |
700 | 1 | a Plenge, Robert M.4 aut |
700 | 1 | a Portas, Laura4 aut |
700 | 1 | a Persico, Ivana4 aut |
700 | 1 | a Kirin, Mirna4 aut |
700 | 1 | a Wilson, James F.4 aut |
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700 | 1 | a van Gilst, Wiek H.4 aut |
700 | 1 | a Goel, Anuj4 aut |
700 | 1 | a Ongen, Halit4 aut |
700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a Rivadeneira, Fernando4 aut |
700 | 1 | a Uitterlinden, Andre G.4 aut |
700 | 1 | a Imboden, Medea4 aut |
700 | 1 | a von Eckardstein, Arnold4 aut |
700 | 1 | a Cucca, Francesco4 aut |
700 | 1 | a Nagaraja, Ramaiah4 aut |
700 | 1 | a Piras, Maria Grazia4 aut |
700 | 1 | a Nauck, Matthias4 aut |
700 | 1 | a Schurmann, Claudia4 aut |
700 | 1 | a Budde, Kathrin4 aut |
700 | 1 | a Ernst, Florian4 aut |
700 | 1 | a Farrington, Susan M.4 aut |
700 | 1 | a Theodoratou, Evropi4 aut |
700 | 1 | a Prokopenko, Inga4 aut |
700 | 1 | a Stumvoll, Michael4 aut |
700 | 1 | a Jula, Antti4 aut |
700 | 1 | a Perola, Markus4 aut |
700 | 1 | a Salomaa, Veikko4 aut |
700 | 1 | a Shin, So-Youn4 aut |
700 | 1 | a Spector, Tim D.4 aut |
700 | 1 | a Sala, Cinzia4 aut |
700 | 1 | a Ridker, Paul M.4 aut |
700 | 1 | a Kaehoenen, Mika4 aut |
700 | 1 | a Viikari, Jorma4 aut |
700 | 1 | a Hengstenberg, Christian4 aut |
700 | 1 | a Nelson, Christopher P.4 aut |
700 | 1 | a Meschia, James F.4 aut |
700 | 1 | a Nalls, Michael A.4 aut |
700 | 1 | a Sharma, Pankaj4 aut |
700 | 1 | a Singleton, Andrew B.4 aut |
700 | 1 | a Kamatani, Naoyuki4 aut |
700 | 1 | a Zeller, Tanja4 aut |
700 | 1 | a Burnier, Michel4 aut |
700 | 1 | a Attia, John4 aut |
700 | 1 | a Laan, Maris4 aut |
700 | 1 | a Klopp, Norman4 aut |
700 | 1 | a Hillege, Hans L.4 aut |
700 | 1 | a Kloiber, Stefan4 aut |
700 | 1 | a Choi, Hyon4 aut |
700 | 1 | a Pirastu, Mario4 aut |
700 | 1 | a Tore, Silvia4 aut |
700 | 1 | a Probst-Hensch, Nicole M.4 aut |
700 | 1 | a Voelzke, Henry4 aut |
700 | 1 | a Gudnason, Vilmundur4 aut |
700 | 1 | a Parsa, Afshin4 aut |
700 | 1 | a Schmidt, Reinhold4 aut |
700 | 1 | a Whitfield, John B.4 aut |
700 | 1 | a Fornage, Myriam4 aut |
700 | 1 | a Gasparini, Paolo4 aut |
700 | 1 | a Siscovick, David S.4 aut |
700 | 1 | a Polasek, Ozren4 aut |
700 | 1 | a Campbell, Harry4 aut |
700 | 1 | a Rudan, Igor4 aut |
700 | 1 | a Bouatia-Naji, Nabila4 aut |
700 | 1 | a Metspalu, Andres4 aut |
700 | 1 | a Loos, Ruth J. F.4 aut |
700 | 1 | a van Duijn, Cornelia M.4 aut |
700 | 1 | a Borecki, Ingrid B.4 aut |
700 | 1 | a Ferrucci, Luigi4 aut |
700 | 1 | a Gambaro, Giovanni4 aut |
700 | 1 | a Deary, Ian J.4 aut |
700 | 1 | a Wolffenbuttel, Bruce H. R.4 aut |
700 | 1 | a Chambers, John C.4 aut |
700 | 1 | a Maerz, Winfried4 aut |
700 | 1 | a Pramstaller, Peter P.4 aut |
700 | 1 | a Snieder, Harold4 aut |
700 | 1 | a Gyllensten, Ulfu Uppsala universitet,Genomik4 aut0 (Swepub:uu)ulfgyll |
700 | 1 | a Wright, Alan F.4 aut |
700 | 1 | a Navis, Gerjan4 aut |
700 | 1 | a Watkins, Hugh4 aut |
700 | 1 | a Witteman, Jacqueline C. M.4 aut |
700 | 1 | a Sanna, Serena4 aut |
700 | 1 | a Schipf, Sabine4 aut |
700 | 1 | a Dunlop, Malcolm G.4 aut |
700 | 1 | a Toenjes, Anke4 aut |
700 | 1 | a Ripatti, Samuli4 aut |
700 | 1 | a Soranzo, Nicole4 aut |
700 | 1 | a Toniolo, Daniela4 aut |
700 | 1 | a Chasman, Daniel I.4 aut |
700 | 1 | a Raitakari, Olli4 aut |
700 | 1 | a Kao, W. H. Linda4 aut |
700 | 1 | a Ciullo, Marina4 aut |
700 | 1 | a Fox, Caroline S.4 aut |
700 | 1 | a Caulfield, Mark4 aut |
700 | 1 | a Bochud, Murielle4 aut |
700 | 1 | a Gieger, Christian4 aut |
710 | 2 | a Uppsala universitetb Uppsala kliniska forskningscentrum (UCR)4 org |
773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 45:2, s. 145-154q 45:2<145-154x 1061-4036x 1546-1718 |
856 | 4 | u https://serval.unil.ch/resource/serval:BIB_772703318942.P001/REF.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-196032 |
856 | 4 8 | u https://doi.org/10.1038/ng.2500 |
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