Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large pooled series from the breast cancer association consortium

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Fältnamn	Indikatorer	Metadata
000		04069naa a2200673 4500
001		oai:DiVA.org:uu-17439
003		SwePub
008		080624s2007 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-174392 URI
024	7	a https://doi.org/10.1158/0008-5472.CAN-07-07382 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Schmidt, Marjanka K4 aut
245	1 0	a Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large pooled series from the breast cancer association consortium
264	1	c 2007
338		a print2 rdacarrier
520		a Association studies in large series of breast cancer patients can be used to identify single-nucleotide polymorphisms (SNP) contributing to breast cancer susceptibility. Previous studies have suggested associations between variants in TP53 (R72P) and MDM2 (SNP309) and cancer risk. Data from molecular studies suggest a functional interaction between these genes. We therefore investigated the effect of TP53 R72P and MDM2 SNP309 on breast cancer risk and age at onset of breast cancer in a pooled series of 5,191 cases and 3,834 controls from the Breast Cancer Association Consortium (BCAC). Breast cancer risk was not found to be associated with the combined variant alleles [odds ratio (OR), 1.00; 95% confidence interval (95% CI), 0.81–1.23]. Estimated ORs were 1.01 (95% CI, 0.93–1.09) per MDM2 SNP309 allele and 0.98 (95% CI, 0.91–1.04) for TP53 R72P. Although we did find evidence for a 4-year earlier age at onset for carriers of both variant alleles in one of the breast cancer patient series of the BCAC (the German series), we were not able to confirm this effect in the pooled analysis. Even so, carriers of both variant alleles did not have different risk estimates for bilateral or estrogen receptor–positive breast cancer. In conclusion, in this large collaborative study, we did not find an association of MDM2 SNP309 and TP53 R72P, separately or in interaction, with breast cancer. This suggests that any effect of these two variants would be very small and possibly confined to subgroups that were not assessed in our present study.
653		a Adolescent
653		a Adult
653		a Age Factors
653		a Aged
653		a Aged; 80 and over
653		a Breast Neoplasms/*genetics/metabolism
653		a Case-Control Studies
653		a Female
653		a Genes; p53/*genetics
653		a Genetic Predisposition to Disease
653		a Humans
653		a Middle Aged
653		a Polymorphism; Single Nucleotide
653		a Proto-Oncogene Proteins c-mdm2/*genetics
653		a Receptors; Estrogen/biosynthesis
653		a MEDICINE
653		a MEDICIN
700	1	a Reincke, Scarlett4 aut
700	1	a Broeks, Annegien4 aut
700	1	a Braaf, Linde M4 aut
700	1	a Hogervorst, Frans B L4 aut
700	1	a Tollenaar, Rob A E M4 aut
700	1	a Johnson, Nichola4 aut
700	1	a Fletcher, Olivia4 aut
700	1	a Peto, Julian4 aut
700	1	a Tommiska, Johanna4 aut
700	1	a Blomqvist, Carlu Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Bröstgruppen4 aut0 (Swepub:uu)carlblom
700	1	a Nevanlinna, Heli A4 aut
700	1	a Healey, Catherine S4 aut
700	1	a Dunning, Alison M4 aut
700	1	a Pharoah, Paul D P4 aut
700	1	a Easton, Douglas F4 aut
700	1	a Dörk, Thilo4 aut
700	1	a Van't Veer, Laura J4 aut
710	2	a Uppsala universitetb Institutionen för onkologi, radiologi och klinisk immunologi4 org
773	0	t Cancer Researchg 67:19, s. 9584-9590q 67:19<9584-9590x 0008-5472x 1538-7445
856	4	u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17909070&dopt=Citation
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-17439
856	4 8	u https://doi.org/10.1158/0008-5472.CAN-07-0738

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