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Health-related qual...
Health-related quality of life in secondary progressive multiple sclerosis.
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Beiske, A G (author)
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Naess, H (author)
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Aarseth, J H (author)
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- Andersen, Oluf, 1941 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
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Elovaara, I (author)
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Farkkila, M (author)
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Hansen, H J (author)
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Mellgren, S I (author)
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Sandberg-Wollheim, M (author)
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Sorensen, P S (author)
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Myhr, K M (author)
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(creator_code:org_t)
- 2007-01-29
- 2007
- English.
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In: Multiple sclerosis (Houndmills, Basingstoke, England). - : SAGE Publications. - 1352-4585 .- 1477-0970. ; 13:3, s. 386-92
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://doi.org/10.1...
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Abstract
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- Common disability scales in multiple sclerosis (MS) are often weighted towards physical disability. Non-motor symptoms such as depression, fatigue and pain substantially influence wellbeing in MS. Health-related quality of life (HRQoL) measures the broader impact of MS and might indicate less obvious disease burdens. We analysed HRQoL, using the Nottingham Health Profile Part I (NHP-I), among 345 secondary progressive MS (SPMS) patients participating in a randomized trial of interferon-beta1a (IFN-beta1a), 22 mug subcutaneously weekly, or matching placebo. The results did not reveal any beneficial effect of IFN-beta1a in any outcome measure. NHP-I sub- and sum scores were compared for 217 population controls and correlated with demographic and clinical disease variables. SPMS patients had lower NHP-I sum and all subscores than the controls. Patients experiencing disease progression reported worse NHP-I sum scores. Increased fatigue, Expanded Disability Status Scale (EDSS) and Arm Index scores were independently associated with reduction in several NHP-I subscores. SPMS patients had significantly lower HRQoL than controls and physical disability (EDSS and Arm Index), disease progression and fatigue strongly influenced this. MS.
Keyword
- Disease Progression
- Emotions
- Fatigue
- Female
- Health Status
- Humans
- Male
- Mobility Limitation
- Multiple Sclerosis
- Chronic Progressive
- physiopathology
- psychology
- Pain
- Quality of Life
- Sleep
- Social Isolation
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Beiske, A G
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Naess, H
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Aarseth, J H
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Andersen, Oluf, ...
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Elovaara, I
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Farkkila, M
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show more...
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Hansen, H J
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Mellgren, S I
-
Sandberg-Wollhei ...
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Sorensen, P S
-
Myhr, K M
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show less...
- Articles in the publication
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Multiple scleros ...
- By the university
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University of Gothenburg