Search: (WFRF:(Giovannucci Edward L)) srt2:(2010-2014) pers:(Kraft Peter) lar1:(uu)
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Genome-wide associa...
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma
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Cerhan, James R. (author)
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Berndt, Sonja I. (author)
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Vijai, Joseph (author)
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Ghesquieres, Herve (author)
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McKay, James (author)
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Wang, Sophia S. (author)
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Wang, Zhaoming (author)
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Yeager, Meredith (author)
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Conde, Lucia (author)
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de Bakker, Paul I. W. (author)
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Nieters, Alexandra (author)
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Cox, David (author)
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Burdett, Laurie (author)
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Monnereau, Alain (author)
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Flowers, Christopher R. (author)
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De Roos, Anneclaire J. (author)
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Brooks-Wilson, Angela R. (author)
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Lan, Qing (author)
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Severi, Gianluca (author)
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Melbye, Mads (author)
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Gu, Jian (author)
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Jackson, Rebecca D. (author)
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- Kane, Eleanor (author)
- Karolinska Institutet
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Teras, Lauren R. (author)
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Purdue, Mark P. (author)
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Vajdic, Claire M. (author)
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Spinelli, John J. (author)
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Giles, Graham G. (author)
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Albanes, Demetrius (author)
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Kelly, Rachel S. (author)
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Zucca, Mariagrazia (author)
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Bertrand, Kimberly A. (author)
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Zeleniuch-Jacquotte, Anne (author)
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Lawrence, Charles (author)
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Hutchinson, Amy (author)
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Zhi, Degui (author)
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Habermann, Thomas M. (author)
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Link, Brian K. (author)
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Novak, Anne J. (author)
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Dogan, Ahmet (author)
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Asmann, Yan W. (author)
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Liebow, Mark (author)
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Thompson, Carrie A. (author)
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Ansell, Stephen M. (author)
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Witzig, Thomas E. (author)
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Weiner, George J. (author)
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Veron, Amelie S. (author)
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Zelenika, Diana (author)
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Tilly, Herve (author)
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Haioun, Corinne (author)
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Molina, Thierry Jo (author)
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- Hjalgrim, Henrik (author)
- Karolinska Institutet
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- Glimelius, Bengt (author)
- Uppsala universitet,Enheten för onkologi
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Adami, Hans-Olov (author)
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Bracci, Paige M. (author)
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Riby, Jacques (author)
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Smith, Martyn T. (author)
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Holly, Elizabeth A. (author)
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Cozen, Wendy (author)
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Hartge, Patricia (author)
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Morton, Lindsay M. (author)
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Severson, Richard K. (author)
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Tinker, Lesley F. (author)
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North, Kari E. (author)
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Becker, Nikolaus (author)
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Benavente, Yolanda (author)
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Boffetta, Paolo (author)
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Brennan, Paul (author)
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Foretova, Lenka (author)
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Maynadie, Marc (author)
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Staines, Anthony (author)
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Lightfoot, Tracy (author)
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Crouch, Simon (author)
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Smith, Alex (author)
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Roman, Eve (author)
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Diver, W. Ryan (author)
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Offit, Kenneth (author)
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Zelenetz, Andrew (author)
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Klein, Robert J. (author)
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Villano, Danylo J. (author)
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Zheng, Tongzhang (author)
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Zhang, Yawei (author)
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Holford, Theodore R. (author)
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Kricker, Anne (author)
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Turner, Jenny (author)
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Southey, Melissa C. (author)
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Clavel, Jacqueline (author)
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Virtamo, Jarmo (author)
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Weinstein, Stephanie (author)
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Riboli, Elio (author)
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Vineis, Paolo (author)
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Kaaks, Rudolph (author)
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Trichopoulos, Dimitrios (author)
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Vermeulen, Roel C. H. (author)
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Boeing, Heiner (author)
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Tjonneland, Anne (author)
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Angelucci, Emanuele (author)
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Di Lollo, Simonetta (author)
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Rais, Marco (author)
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Birmann, Brenda M. (author)
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Laden, Francine (author)
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Giovannucci, Edward (author)
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Kraft, Peter (author)
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Huang, Jinyan (author)
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Ma, Baoshan (author)
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Ye, Yuanqing (author)
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Chiu, Brian C. H. (author)
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Sampson, Joshua (author)
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Liang, Liming (author)
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Park, Ju-Hyun (author)
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Chung, Charles C. (author)
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Weisenburger, Dennis D. (author)
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Chatterjee, Nilanjan (author)
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Fraumeni, Joseph F., Jr. (author)
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Slager, Susan L. (author)
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Wu, Xifeng (author)
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de Sanjose, Silvia (author)
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Smedby, Karin E. (author)
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Salles, Gilles (author)
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Skibola, Christine F. (author)
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Rothman, Nathaniel (author)
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Chanock, Stephen J. (author)
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(creator_code:org_t)
- 2014-09-28
- 2014
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 46:11, s. 1233-1238
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
Close
- Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 x 10(-21)), rs2523607 at 6p21.33 (HLA-B; P = 2.40 x 10(-10)), rs79480871 at 2p23.3 (NCOA1; P = 4.23 x 10(-8)) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 x 10(-13) and 3.63 x 10(-11), respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Cerhan, James R.
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Berndt, Sonja I.
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Vijai, Joseph
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Ghesquieres, Her ...
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McKay, James
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Wang, Sophia S.
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show more...
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Wang, Zhaoming
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Yeager, Meredith
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Conde, Lucia
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de Bakker, Paul ...
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Nieters, Alexand ...
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Cox, David
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Burdett, Laurie
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Monnereau, Alain
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Flowers, Christo ...
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De Roos, Annecla ...
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Brooks-Wilson, A ...
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Lan, Qing
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Severi, Gianluca
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Melbye, Mads
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Gu, Jian
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Jackson, Rebecca ...
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Kane, Eleanor
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Teras, Lauren R.
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Purdue, Mark P.
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Vajdic, Claire M ...
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Spinelli, John J ...
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Giles, Graham G.
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Albanes, Demetri ...
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Kelly, Rachel S.
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Zucca, Mariagraz ...
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Bertrand, Kimber ...
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Zeleniuch-Jacquo ...
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Lawrence, Charle ...
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Hutchinson, Amy
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Zhi, Degui
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Habermann, Thoma ...
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Link, Brian K.
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Novak, Anne J.
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Dogan, Ahmet
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Asmann, Yan W.
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Liebow, Mark
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Thompson, Carrie ...
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Ansell, Stephen ...
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Witzig, Thomas E ...
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Weiner, George J ...
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Veron, Amelie S.
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Zelenika, Diana
-
Tilly, Herve
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Haioun, Corinne
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Molina, Thierry ...
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Hjalgrim, Henrik
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Glimelius, Bengt
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Adami, Hans-Olov
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Bracci, Paige M.
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Riby, Jacques
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Smith, Martyn T.
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Holly, Elizabeth ...
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Cozen, Wendy
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Hartge, Patricia
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Morton, Lindsay ...
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Severson, Richar ...
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Tinker, Lesley F ...
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North, Kari E.
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Becker, Nikolaus
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Benavente, Yolan ...
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Boffetta, Paolo
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Brennan, Paul
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Foretova, Lenka
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Maynadie, Marc
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Staines, Anthony
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Lightfoot, Tracy
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Crouch, Simon
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Smith, Alex
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Roman, Eve
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Diver, W. Ryan
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Offit, Kenneth
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Zelenetz, Andrew
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Klein, Robert J.
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Villano, Danylo ...
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Zheng, Tongzhang
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Zhang, Yawei
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Holford, Theodor ...
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Kricker, Anne
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Turner, Jenny
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Southey, Melissa ...
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Clavel, Jacqueli ...
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Virtamo, Jarmo
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Weinstein, Steph ...
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Riboli, Elio
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Vineis, Paolo
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Kaaks, Rudolph
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Trichopoulos, Di ...
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Vermeulen, Roel ...
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Boeing, Heiner
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Tjonneland, Anne
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Angelucci, Emanu ...
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Di Lollo, Simone ...
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Rais, Marco
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Birmann, Brenda ...
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Laden, Francine
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Giovannucci, Edw ...
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Kraft, Peter
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Huang, Jinyan
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Ma, Baoshan
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Ye, Yuanqing
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Chiu, Brian C. H ...
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Sampson, Joshua
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Liang, Liming
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Park, Ju-Hyun
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Chung, Charles C ...
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Weisenburger, De ...
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Chatterjee, Nila ...
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Fraumeni, Joseph ...
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Slager, Susan L.
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Wu, Xifeng
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de Sanjose, Silv ...
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Smedby, Karin E.
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Salles, Gilles
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Skibola, Christi ...
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Rothman, Nathani ...
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Chanock, Stephen ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Nature Genetics
- By the university
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Uppsala University
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Karolinska Institutet