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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
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| 001 | oai:DiVA.org:umu-197707 | |
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| 008 | 220704s2022 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:148629611 | |
| 009 | oai:gup.ub.gu.se/312368 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1977072 URI |
| 024 | 7 | a https://doi.org/10.1016/j.biopsych.2021.05.0292 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1486296112 URI |
| 024 | 7 | a https://gup.ub.gu.se/publication/3123682 URI |
| 040 | a (SwePub)umud (SwePub)kid (SwePub)gu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
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| 100 | 1 | a Mullins, Niamh4 aut |
| 245 | 1 0 | a Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors |
| 264 | 1 | b Elsevier,c 2022 |
| 338 | a electronic2 rdacarrier | |
| 520 | a BACKGROUND: Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders.METHODS: We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors.RESULTS: Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged.CONCLUSIONS: Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
| 653 | a Genetic correlation | |
| 653 | a Genome-wide association study | |
| 653 | a Pleiotropy | |
| 653 | a Polygenicity | |
| 653 | a Suicide | |
| 653 | a Suicide attempt | |
| 700 | 1 | a Kang, JooEun4 aut |
| 700 | 1 | a Campos, Adrian I.4 aut |
| 700 | 1 | a Coleman, Jonathan R. I.4 aut |
| 700 | 1 | a Edwards, Alexis C.4 aut |
| 700 | 1 | a Galfalvy, Hanga4 aut |
| 700 | 1 | a Levey, Daniel F.4 aut |
| 700 | 1 | a Lori, Adriana4 aut |
| 700 | 1 | a Shabalin, Andrey4 aut |
| 700 | 1 | a Starnawska, Anna4 aut |
| 700 | 1 | a Su, Mei-Hsin4 aut |
| 700 | 1 | a Watson, Hunna J.4 aut |
| 700 | 1 | a Adams, Mark4 aut |
| 700 | 1 | a Awasthi, Swapnil4 aut |
| 700 | 1 | a Gandal, Michael4 aut |
| 700 | 1 | a Hafferty, Jonathan D.4 aut |
| 700 | 1 | a Hishimoto, Akitoyo4 aut |
| 700 | 1 | a Kim, Minsoo4 aut |
| 700 | 1 | a Okazaki, Satoshi4 aut |
| 700 | 1 | a Otsuka, Ikuo4 aut |
| 700 | 1 | a Ripke, Stephan4 aut |
| 700 | 1 | a Ware, Erin B.4 aut |
| 700 | 1 | a Bergen, Andrew W.4 aut |
| 700 | 1 | a Berrettini, Wade H.4 aut |
| 700 | 1 | a Bohus, Martin4 aut |
| 700 | 1 | a Brandt, Harry4 aut |
| 700 | 1 | a Chang, Xiao4 aut |
| 700 | 1 | a Chen, Wei J.4 aut |
| 700 | 1 | a Chen, Hsi-Chung4 aut |
| 700 | 1 | a Crawford, Steven4 aut |
| 700 | 1 | a Crow, Scott4 aut |
| 700 | 1 | a DiBlasi, Emily4 aut |
| 700 | 1 | a Duriez, Philibert4 aut |
| 700 | 1 | a Fernández-Aranda, Fernando4 aut |
| 700 | 1 | a Fichter, Manfred M.4 aut |
| 700 | 1 | a Gallinger, Steven4 aut |
| 700 | 1 | a Glatt, Stephen J.4 aut |
| 700 | 1 | a Gorwood, Philip4 aut |
| 700 | 1 | a Guo, Yiran4 aut |
| 700 | 1 | a Hakonarson, Hakon4 aut |
| 700 | 1 | a Halmi, Katherine A.4 aut |
| 700 | 1 | a Hwu, Hai-Gwo4 aut |
| 700 | 1 | a Jain, Sonia4 aut |
| 700 | 1 | a Jamain, Stéphane4 aut |
| 700 | 1 | a Jiménez-Murcia, Susana4 aut |
| 700 | 1 | a Johnson, Craig4 aut |
| 700 | 1 | a Kaplan, Allan S.4 aut |
| 700 | 1 | a Kaye, Walter H.4 aut |
| 700 | 1 | a Keel, Pamela K.4 aut |
| 700 | 1 | a Kennedy, James L.4 aut |
| 700 | 1 | a Klump, Kelly L.4 aut |
| 700 | 1 | a Li, Dong4 aut |
| 700 | 1 | a Liao, Shih-Cheng4 aut |
| 700 | 1 | a Lieb, Klaus4 aut |
| 700 | 1 | a Lilenfeld, Lisau Karolinska Institutet4 aut |
| 700 | 1 | a Liu, Chih-Min4 aut |
| 700 | 1 | a Magistretti, Pierre J.4 aut |
| 700 | 1 | a Marshall, Christian R.4 aut |
| 700 | 1 | a Mitchell, James E.4 aut |
| 700 | 1 | a Monson, Eric T.4 aut |
| 700 | 1 | a Myers, Richard M.4 aut |
| 700 | 1 | a Pinto, Dalila4 aut |
| 700 | 1 | a Powers, Abigail4 aut |
| 700 | 1 | a Ramoz, Nicolas4 aut |
| 700 | 1 | a Roepke, Stefan4 aut |
| 700 | 1 | a Rozanov, Vsevolod4 aut |
| 700 | 1 | a Scherer, Stephen W.4 aut |
| 700 | 1 | a Schmahl, Christian4 aut |
| 700 | 1 | a Sokolowski, Marcusu Karolinska Institutet4 aut |
| 700 | 1 | a Strober, Michael4 aut |
| 700 | 1 | a Thornton, Laura M.4 aut |
| 700 | 1 | a Treasure, Janet4 aut |
| 700 | 1 | a Tsuang, Ming T.4 aut |
| 700 | 1 | a Witt, Stephanie H.4 aut |
| 700 | 1 | a Woodside, D. Blake4 aut |
| 700 | 1 | a Yilmaz, Zeynep4 aut |
| 700 | 1 | a Zillich, Lea4 aut |
| 700 | 1 | a Adolfsson, Rolfu Umeå universitet,Psykiatri4 aut0 (Swepub:umu)road0001 |
| 700 | 1 | a Agartz, Ingridu Karolinska Institutet4 aut |
| 700 | 1 | a Air, Tracy M.4 aut |
| 700 | 1 | a Alda, Martin4 aut |
| 700 | 1 | a Alfredsson, Lars4 aut |
| 700 | 1 | a Andreassen, Ole A.4 aut |
| 700 | 1 | a Anjorin, Adebayo4 aut |
| 700 | 1 | a Appadurai, Vivek4 aut |
| 700 | 1 | a Soler Artigas, María4 aut |
| 700 | 1 | a Van der Auwera, Sandra4 aut |
| 700 | 1 | a Azevedo, M. Helena4 aut |
| 700 | 1 | a Bass, Nicholas4 aut |
| 700 | 1 | a Bau, Claiton H. D.4 aut |
| 700 | 1 | a Baune, Bernhard T.4 aut |
| 700 | 1 | a Bellivier, Frank4 aut |
| 700 | 1 | a Berger, Klaus4 aut |
| 700 | 1 | a Biernacka, Joanna M.4 aut |
| 700 | 1 | a Bigdeli, Tim B.4 aut |
| 700 | 1 | a Binder, Elisabeth B.4 aut |
| 700 | 1 | a Boehnke, Michael4 aut |
| 700 | 1 | a Boks, Marco P.4 aut |
| 700 | 1 | a Bosch, Rosa4 aut |
| 700 | 1 | a Braff, David L.4 aut |
| 700 | 1 | a Bryant, Richard4 aut |
| 700 | 1 | a Budde, Monika4 aut |
| 700 | 1 | a Byrne, Enda M.4 aut |
| 700 | 1 | a Cahn, Wiepke4 aut |
| 700 | 1 | a Casas, Miguelu Karolinska Institutet4 aut |
| 700 | 1 | a Castelao, Enrique4 aut |
| 700 | 1 | a Cervilla, Jorge A.4 aut |
| 700 | 1 | a Chaumette, Boris4 aut |
| 700 | 1 | a Cichon, Sven4 aut |
| 700 | 1 | a Corvin, Aiden4 aut |
| 700 | 1 | a Craddock, Nicholas4 aut |
| 700 | 1 | a Craig, David4 aut |
| 700 | 1 | a Degenhardt, Franziska4 aut |
| 700 | 1 | a Djurovic, Srdjan4 aut |
| 700 | 1 | a Edenberg, Howard J.4 aut |
| 700 | 1 | a Fanous, Ayman H.4 aut |
| 700 | 1 | a Foo, Jerome C.4 aut |
| 700 | 1 | a Forstner, Andreas J.4 aut |
| 700 | 1 | a Frye, Mark4 aut |
| 700 | 1 | a Fullerton, Janice M.4 aut |
| 700 | 1 | a Gatt, Justine M.4 aut |
| 700 | 1 | a Gejman, Pablo V.4 aut |
| 700 | 1 | a Giegling, Ina4 aut |
| 700 | 1 | a Grabe, Hans J.4 aut |
| 700 | 1 | a Green, Melissa J.4 aut |
| 700 | 1 | a Grevet, Eugenio H.4 aut |
| 700 | 1 | a Grigoroiu-Serbanescu, Maria4 aut |
| 700 | 1 | a Gutierrez, Blanca4 aut |
| 700 | 1 | a Guzman-Parra, Jose4 aut |
| 700 | 1 | a Hamilton, Steven P.4 aut |
| 700 | 1 | a Hamshere, Marian L.4 aut |
| 700 | 1 | a Hartmann, Annette4 aut |
| 700 | 1 | a Hauser, Joanna4 aut |
| 700 | 1 | a Heilmann-Heimbach, Stefanie4 aut |
| 700 | 1 | a Hoffmann, Per4 aut |
| 700 | 1 | a Ising, Marcus4 aut |
| 700 | 1 | a Jones, Ian4 aut |
| 700 | 1 | a Jones, Lisa A.4 aut |
| 700 | 1 | a Jonsson, Lina,d 1982u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xjliny |
| 700 | 1 | a Kahn, René S.4 aut |
| 700 | 1 | a Kelsoe, John R.4 aut |
| 700 | 1 | a Kendler, Kenneth S.4 aut |
| 700 | 1 | a Kloiber, Stefan4 aut |
| 700 | 1 | a Koenen, Karestan C.4 aut |
| 700 | 1 | a Kogevinas, Manolis4 aut |
| 700 | 1 | a Konte, Bettina4 aut |
| 700 | 1 | a Krebs, Marie-Odile4 aut |
| 700 | 1 | a Landén, Mikael,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlandt |
| 700 | 1 | a Lawrence, Jacob4 aut |
| 700 | 1 | a Leboyer, Marion4 aut |
| 700 | 1 | a Lee, Phil H.4 aut |
| 700 | 1 | a Levinson, Douglas F.4 aut |
| 700 | 1 | a Liao, Calwing4 aut |
| 700 | 1 | a Lissowska, Jolanta4 aut |
| 700 | 1 | a Lucae, Susanne4 aut |
| 700 | 1 | a Mayoral, Fermin4 aut |
| 700 | 1 | a McElroy, Susan L.4 aut |
| 700 | 1 | a McGrath, Patrick4 aut |
| 700 | 1 | a McGuffin, Peter4 aut |
| 700 | 1 | a McQuillin, Andrew4 aut |
| 700 | 1 | a Medland, Sarah E.4 aut |
| 700 | 1 | a Mehta, Divya4 aut |
| 700 | 1 | a Melle, Ingrid4 aut |
| 700 | 1 | a Milaneschi, Yuri4 aut |
| 700 | 1 | a Mitchell, Philip B.4 aut |
| 700 | 1 | a Molina, Esther4 aut |
| 700 | 1 | a Morken, Gunnar4 aut |
| 700 | 1 | a Mortensen, Preben Bo4 aut |
| 700 | 1 | a Müller-Myhsok, Bertram4 aut |
| 700 | 1 | a Nievergelt, Caroline4 aut |
| 700 | 1 | a Nimgaonkar, Vishwajit4 aut |
| 700 | 1 | a Nöthen, Markus M.4 aut |
| 700 | 1 | a O'Donovan, Michael C.4 aut |
| 700 | 1 | a Ophoff, Roel A.4 aut |
| 700 | 1 | a Owen, Michael J.4 aut |
| 700 | 1 | a Pato, Carlos4 aut |
| 700 | 1 | a Pato, Michele T.4 aut |
| 700 | 1 | a Penninx, Brenda W. J. H.4 aut |
| 700 | 1 | a Pimm, Jonathan4 aut |
| 700 | 1 | a Pistis, Giorgio4 aut |
| 700 | 1 | a Potash, James B.4 aut |
| 700 | 1 | a Power, Robert A.4 aut |
| 700 | 1 | a Preisig, Martin4 aut |
| 700 | 1 | a Quested, Digby4 aut |
| 700 | 1 | a Ramos-Quiroga, Josep Antoni4 aut |
| 700 | 1 | a Reif, Andreas4 aut |
| 700 | 1 | a Ribasés, Marta4 aut |
| 700 | 1 | a Richarte, Vanesa4 aut |
| 700 | 1 | a Rietschel, Marcella4 aut |
| 700 | 1 | a Rivera, Margarita4 aut |
| 700 | 1 | a Roberts, Andrea4 aut |
| 700 | 1 | a Roberts, Gloria4 aut |
| 700 | 1 | a Rouleau, Guy A.4 aut |
| 700 | 1 | a Rovaris, Diego L.4 aut |
| 700 | 1 | a Rujescu, Dan4 aut |
| 700 | 1 | a Sánchez-Mora, Cristina4 aut |
| 700 | 1 | a Sanders, Alan R.4 aut |
| 700 | 1 | a Schofield, Peter R.4 aut |
| 700 | 1 | a Schulze, Thomas G.4 aut |
| 700 | 1 | a Scott, Laura J.4 aut |
| 700 | 1 | a Serretti, Alessandro4 aut |
| 700 | 1 | a Shi, Jianxin4 aut |
| 700 | 1 | a Shyn, Stanley I.4 aut |
| 700 | 1 | a Sirignano, Lea4 aut |
| 700 | 1 | a Sklar, Pamela4 aut |
| 700 | 1 | a Smeland, Olav B.4 aut |
| 700 | 1 | a Smoller, Jordan W.4 aut |
| 700 | 1 | a Sonuga-Barke, Edmund J. S.4 aut |
| 700 | 1 | a Spalletta, Gianfranco4 aut |
| 700 | 1 | a Strauss, John S.4 aut |
| 700 | 1 | a Świątkowska, Beata4 aut |
| 700 | 1 | a Trzaskowski, Maciej4 aut |
| 700 | 1 | a Turecki, Gustavo4 aut |
| 700 | 1 | a Vilar-Ribó, Laura4 aut |
| 700 | 1 | a Vincent, John B.4 aut |
| 700 | 1 | a Völzke, Henry4 aut |
| 700 | 1 | a Walters, James T. R.4 aut |
| 700 | 1 | a Shannon Weickert, Cynthia4 aut |
| 700 | 1 | a Weickert, Thomas W.4 aut |
| 700 | 1 | a Weissman, Myrna M.4 aut |
| 700 | 1 | a Williams, Leanne M.4 aut |
| 700 | 1 | a Wray, Naomi R.4 aut |
| 700 | 1 | a Zai, Clement C.4 aut |
| 700 | 1 | a Ashley-Koch, Allison E.4 aut |
| 700 | 1 | a Beckham, Jean C.4 aut |
| 700 | 1 | a Hauser, Elizabeth R.4 aut |
| 700 | 1 | a Hauser, Michael A.4 aut |
| 700 | 1 | a Kimbrel, Nathan A.4 aut |
| 700 | 1 | a Lindquist, Jennifer H.4 aut |
| 700 | 1 | a McMahon, Benjamin4 aut |
| 700 | 1 | a Oslin, David W.u Karolinska Institutet4 aut |
| 700 | 1 | a Qin, Xuejun4 aut |
| 700 | 1 | a Agerbo, Esben4 aut |
| 700 | 1 | a Børglum, Anders D.4 aut |
| 700 | 1 | a Breen, Gerome4 aut |
| 700 | 1 | a Erlangsen, Annette4 aut |
| 700 | 1 | a Esko, Tõnu4 aut |
| 700 | 1 | a Gelernter, Joel4 aut |
| 700 | 1 | a Hougaard, David M.4 aut |
| 700 | 1 | a Kessler, Ronald C.4 aut |
| 700 | 1 | a Kranzler, Henry R.4 aut |
| 700 | 1 | a Li, Qingqin S.4 aut |
| 700 | 1 | a Martin, Nicholas G.4 aut |
| 700 | 1 | a McIntosh, Andrew M.4 aut |
| 700 | 1 | a Mors, Ole4 aut |
| 700 | 1 | a Nordentoft, Merete4 aut |
| 700 | 1 | a Olsen, Catherine M.4 aut |
| 700 | 1 | a Porteous, David4 aut |
| 700 | 1 | a Ursano, Robert J.4 aut |
| 700 | 1 | a Wasserman, Danuta4 aut |
| 700 | 1 | a Werge, Thomas4 aut |
| 700 | 1 | a Whiteman, David C.4 aut |
| 700 | 1 | a Bulik, Cynthia M.4 aut |
| 700 | 1 | a Coon, Hilary4 aut |
| 700 | 1 | a Demontis, Ditte4 aut |
| 700 | 1 | a Docherty, Anna R.4 aut |
| 700 | 1 | a Kuo, Po-Hsiu4 aut |
| 700 | 1 | a Lewis, Cathryn M.4 aut |
| 700 | 1 | a Mann, J. John4 aut |
| 700 | 1 | a Rentería, Miguel E.4 aut |
| 700 | 1 | a Smith, Daniel J.4 aut |
| 700 | 1 | a Stahl, Eli A.4 aut |
| 700 | 1 | a Stein, Murray B.4 aut |
| 700 | 1 | a Streit, Fabian4 aut |
| 700 | 1 | a Willour, Virginia4 aut |
| 700 | 1 | a Ruderfer, Douglas M.4 aut |
| 710 | 2 | a Karolinska Institutetb Psykiatri4 org |
| 773 | 0 | t Biological Psychiatryd : Elsevierg 91:3, s. 313-327q 91:3<313-327x 0006-3223x 1873-2402 |
| 856 | 4 | u https://doi.org/10.1016/j.biopsych.2021.05.029y Fulltext |
| 856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1680203/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u http://www.biologicalpsychiatryjournal.com/article/S0006322321015705/pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-197707 |
| 856 | 4 8 | u https://doi.org/10.1016/j.biopsych.2021.05.029 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:148629611 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/312368 |
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