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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 15304naa a2203553 4500 | |
| 001 | oai:DiVA.org:uu-211783 | |
| 003 | SwePub | |
| 008 | 131202s2013 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:4f07f785-c869-40bb-9154-2164c325b5a9 | |
| 009 | oai:prod.swepub.kib.ki.se:127684100 | |
| 009 | oai:DiVA.org:umu-83626 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2117832 URI |
| 024 | 7 | a https://doi.org/10.1038/ng.27972 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/42045832 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1276841002 URI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-836262 URI |
| 040 | a (SwePub)uud (SwePub)lud (SwePub)kid (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Willer, Cristen J.4 aut |
| 245 | 1 0 | a Discovery and refinement of loci associated with lipid levels |
| 264 | c 2013-10-06 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2013 |
| 338 | a print2 rdacarrier | |
| 500 | a De sex sista författarna delar sistaförfattarskapet. | |
| 520 | a Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 x 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 700 | 1 | a Schmidt, Ellen M.4 aut |
| 700 | 1 | a Sengupta, Sebanti4 aut |
| 700 | 1 | a Peloso, Gina M.4 aut |
| 700 | 1 | a Gustafsson, Stefanu Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)stegu732 |
| 700 | 1 | a Kanoni, Stavroula4 aut |
| 700 | 1 | a Ganna, Andreau Karolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut |
| 700 | 1 | a Chen, Jin4 aut |
| 700 | 1 | a Lind, Larsu Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)larslind |
| 700 | 1 | a Mora, Samia4 aut |
| 700 | 1 | a Beckmann, Jacques S.4 aut |
| 700 | 1 | a Bragg-Gresham, Jennifer L.4 aut |
| 700 | 1 | a Chang, Hsing-Yi4 aut |
| 700 | 1 | a Demirkan, Ayse4 aut |
| 700 | 1 | a Den Hertog, Heleen M.4 aut |
| 700 | 1 | a Do, Ron4 aut |
| 700 | 1 | a Donnelly, Louise A.4 aut |
| 700 | 1 | a Ehret, Georg B.4 aut |
| 700 | 1 | a Esko, Tonu4 aut |
| 700 | 1 | a Feitosa, Mary F.4 aut |
| 700 | 1 | a Ferreira, Teresa4 aut |
| 700 | 1 | a Fischer, Krista4 aut |
| 700 | 1 | a Fontanillas, Pierre4 aut |
| 700 | 1 | a Fraser, Ross M.4 aut |
| 700 | 1 | a Freitag, Daniel F.4 aut |
| 700 | 1 | a Gurdasani, Deepti4 aut |
| 700 | 1 | a Heikkila, Kauko4 aut |
| 700 | 1 | a Hyppoenen, Elina4 aut |
| 700 | 1 | a Isaacs, Aaron4 aut |
| 700 | 1 | a Jackson, Anne U.4 aut |
| 700 | 1 | a Johansson, Åsau Uppsala universitet,Genomik,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)asjoh108 |
| 700 | 1 | a Johnson, Toby4 aut |
| 700 | 1 | a Kaakinen, Marika4 aut |
| 700 | 1 | a Kettunen, Johannes4 aut |
| 700 | 1 | a Kleber, Marcus E.4 aut |
| 700 | 1 | a Li, Xiaohui4 aut |
| 700 | 1 | a Luan, Jian'an4 aut |
| 700 | 1 | a Lyytikainen, Leo-Pekka4 aut |
| 700 | 1 | a Magnusson, Patrik K. E.u Karolinska Institutet4 aut |
| 700 | 1 | a Mangino, Massimo4 aut |
| 700 | 1 | a Mihailov, Evelin4 aut |
| 700 | 1 | a Montasser, May E.4 aut |
| 700 | 1 | a Mueller-Nurasyid, Martina4 aut |
| 700 | 1 | a Nolte, Ilja M.4 aut |
| 700 | 1 | a O'Connell, Jeffrey R.4 aut |
| 700 | 1 | a Palmer, Cameron D.4 aut |
| 700 | 1 | a Perola, Markus4 aut |
| 700 | 1 | a Petersen, Ann-Kristin4 aut |
| 700 | 1 | a Sanna, Serena4 aut |
| 700 | 1 | a Saxena, Richa4 aut |
| 700 | 1 | a Service, Susan K.4 aut |
| 700 | 1 | a Shah, Sonia4 aut |
| 700 | 1 | a Shungin, Dmitryu Umeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Medicin,Institutionen för odontologi4 aut0 (Swepub:umu)dmsh0003 |
| 700 | 1 | a Sidore, Carlo4 aut |
| 700 | 1 | a Song, Ciu Karolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)ciaso492 |
| 700 | 1 | a Strawbridge, Rona J.u Karolinska Institutet4 aut |
| 700 | 1 | a Surakka, Ida4 aut |
| 700 | 1 | a Tanaka, Toshiko4 aut |
| 700 | 1 | a Teslovich, Tanya M.4 aut |
| 700 | 1 | a Thorleifsson, Gudmar4 aut |
| 700 | 1 | a Van den Herik, Evita G.4 aut |
| 700 | 1 | a Voight, Benjamin F.4 aut |
| 700 | 1 | a Volcik, Kelly A.4 aut |
| 700 | 1 | a Waite, Lindsay L.4 aut |
| 700 | 1 | a Wong, Andrew4 aut |
| 700 | 1 | a Wu, Ying4 aut |
| 700 | 1 | a Zhang, Weihua4 aut |
| 700 | 1 | a Absher, Devin4 aut |
| 700 | 1 | a Asiki, Gershim4 aut |
| 700 | 1 | a Barroso, Ines4 aut |
| 700 | 1 | a Been, Latonya F.4 aut |
| 700 | 1 | a Bolton, Jennifer L.4 aut |
| 700 | 1 | a Bonnycastle, Lori L.4 aut |
| 700 | 1 | a Brambilla, Paolo4 aut |
| 700 | 1 | a Burnett, Mary S.4 aut |
| 700 | 1 | a Cesana, Giancarlo4 aut |
| 700 | 1 | a Dimitriou, Maria4 aut |
| 700 | 1 | a Doney, Alex S. F.4 aut |
| 700 | 1 | a Doering, Angela4 aut |
| 700 | 1 | a Elliott, Paul4 aut |
| 700 | 1 | a Epstein, Stephen E.4 aut |
| 700 | 1 | a Eyjolfsson, Gudmundur Ingi4 aut |
| 700 | 1 | a Gigante, Brunau Karolinska Institutet4 aut |
| 700 | 1 | a Goodarzi, Mark O.4 aut |
| 700 | 1 | a Grallert, Harald4 aut |
| 700 | 1 | a Gravito, Martha L.4 aut |
| 700 | 1 | a Groves, Christopher J.4 aut |
| 700 | 1 | a Hallmans, Göranu Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)goha0001 |
| 700 | 1 | a Hartikainen, Anna-Liisa4 aut |
| 700 | 1 | a Hayward, Caroline4 aut |
| 700 | 1 | a Hernandez, Dena4 aut |
| 700 | 1 | a Hicks, Andrew A.4 aut |
| 700 | 1 | a Holm, Hilma4 aut |
| 700 | 1 | a Hung, Yi-Jen4 aut |
| 700 | 1 | a Illig, Thomas4 aut |
| 700 | 1 | a Jones, Michelle R.4 aut |
| 700 | 1 | a Kaleebu, Pontiano4 aut |
| 700 | 1 | a Kastelein, John J. P.4 aut |
| 700 | 1 | a Khaw, Kay-Tee4 aut |
| 700 | 1 | a Kim, Eric4 aut |
| 700 | 1 | a Klopp, Norman4 aut |
| 700 | 1 | a Komulainen, Pirjo4 aut |
| 700 | 1 | a Kumari, Meena4 aut |
| 700 | 1 | a Langenberg, Claudia4 aut |
| 700 | 1 | a Lehtimaki, Terho4 aut |
| 700 | 1 | a Lin, Shih-Yi4 aut |
| 700 | 1 | a Lindstrom, Jaana4 aut |
| 700 | 1 | a Loos, Ruth J. F.4 aut |
| 700 | 1 | a Mach, Francois4 aut |
| 700 | 1 | a McArdle, Wendy L.4 aut |
| 700 | 1 | a Meisinger, Christa4 aut |
| 700 | 1 | a Mitchell, Braxton D.4 aut |
| 700 | 1 | a Mueller, Gabrielle4 aut |
| 700 | 1 | a Nagaraja, Ramaiah4 aut |
| 700 | 1 | a Narisu, Narisuu Karolinska Institutet4 aut |
| 700 | 1 | a Nieminen, Tuomo V. M.4 aut |
| 700 | 1 | a Nsubuga, Rebecca N.4 aut |
| 700 | 1 | a Olafsson, Isleifur4 aut |
| 700 | 1 | a Ong, Ken K.4 aut |
| 700 | 1 | a Palotie, Aarno4 aut |
| 700 | 1 | a Papamarkou, Theodore4 aut |
| 700 | 1 | a Pomilla, Cristina4 aut |
| 700 | 1 | a Pouta, Anneli4 aut |
| 700 | 1 | a Rader, Daniel J.4 aut |
| 700 | 1 | a Reilly, Muredach P.4 aut |
| 700 | 1 | a Ridker, Paul M.4 aut |
| 700 | 1 | a Rivadeneira, Fernando4 aut |
| 700 | 1 | a Rudan, Igor4 aut |
| 700 | 1 | a Ruokonen, Aimo4 aut |
| 700 | 1 | a Samani, Nilesh4 aut |
| 700 | 1 | a Scharnagl, Hubert4 aut |
| 700 | 1 | a Seeley, Janet4 aut |
| 700 | 1 | a Silander, Kaisa4 aut |
| 700 | 1 | a Stancakova, Alena4 aut |
| 700 | 1 | a Stirrups, Kathleen4 aut |
| 700 | 1 | a Swift, Amy J.4 aut |
| 700 | 1 | a Tiret, Laurence4 aut |
| 700 | 1 | a Uitterlinden, Andre G.4 aut |
| 700 | 1 | a van Pelt, L. Joost4 aut |
| 700 | 1 | a Vedantam, Sailaja4 aut |
| 700 | 1 | a Wainwright, Nicholas4 aut |
| 700 | 1 | a Wijmenga, Cisca4 aut |
| 700 | 1 | a Wild, Sarah H.4 aut |
| 700 | 1 | a Willemsen, Gonneke4 aut |
| 700 | 1 | a Wilsgaard, Tom4 aut |
| 700 | 1 | a Wilson, James F.4 aut |
| 700 | 1 | a Young, Elizabeth H.4 aut |
| 700 | 1 | a Zhao, Jing Hua4 aut |
| 700 | 1 | a Adair, Linda S.4 aut |
| 700 | 1 | a Arveiler, Dominique4 aut |
| 700 | 1 | a Assimes, Themistocles L.4 aut |
| 700 | 1 | a Bandinelli, Stefania4 aut |
| 700 | 1 | a Bennett, Franklyn4 aut |
| 700 | 1 | a Bochud, Murielle4 aut |
| 700 | 1 | a Boehm, Bernhard O.4 aut |
| 700 | 1 | a Boomsma, Dorret I.4 aut |
| 700 | 1 | a Borecki, Ingrid B.4 aut |
| 700 | 1 | a Bornstein, Stefan R.4 aut |
| 700 | 1 | a Bovet, Pascal4 aut |
| 700 | 1 | a Burnier, Michel4 aut |
| 700 | 1 | a Campbell, Harry4 aut |
| 700 | 1 | a Chakravarti, Aravinda4 aut |
| 700 | 1 | a Chambers, John C.4 aut |
| 700 | 1 | a Chen, Yii-Der Ida4 aut |
| 700 | 1 | a Collins, Francis S.4 aut |
| 700 | 1 | a Cooper, Richard S.4 aut |
| 700 | 1 | a Danesh, John4 aut |
| 700 | 1 | a Dedoussis, George4 aut |
| 700 | 1 | a de Faire, Ulfu Karolinska Institutet4 aut |
| 700 | 1 | a Feranil, Alan B.4 aut |
| 700 | 1 | a Ferrieres, Jean4 aut |
| 700 | 1 | a Ferrucci, Luigi4 aut |
| 700 | 1 | a Freimer, Nelson B.4 aut |
| 700 | 1 | a Gieger, Christian4 aut |
| 700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr |
| 700 | 1 | a Gudnason, Vilmundur4 aut |
| 700 | 1 | a Gyllensten, Ulfu Uppsala universitet,Genomik4 aut0 (Swepub:uu)ulfgyll |
| 700 | 1 | a Hamsten, Andersu Karolinska Institutet4 aut |
| 700 | 1 | a Harris, Tamara B.4 aut |
| 700 | 1 | a Hingorani, Aroon4 aut |
| 700 | 1 | a Hirschhorn, Joel N.4 aut |
| 700 | 1 | a Hofman, Albert4 aut |
| 700 | 1 | a Hovingh, G. Kees4 aut |
| 700 | 1 | a Hsiung, Chao Agnes4 aut |
| 700 | 1 | a Humphries, Steve E.4 aut |
| 700 | 1 | a Hunt, Steven C.4 aut |
| 700 | 1 | a Hveem, Kristian4 aut |
| 700 | 1 | a Iribarren, Carlos4 aut |
| 700 | 1 | a Jarvelin, Marjo-Riitta4 aut |
| 700 | 1 | a Jula, Antti4 aut |
| 700 | 1 | a Kahonen, Mika4 aut |
| 700 | 1 | a Kaprio, Jaakko4 aut |
| 700 | 1 | a Kesaniemi, Antero4 aut |
| 700 | 1 | a Kivimaki, Mika4 aut |
| 700 | 1 | a Kooner, Jaspal S.4 aut |
| 700 | 1 | a Koudstaal, Peter J.4 aut |
| 700 | 1 | a Krauss, Ronald M.4 aut |
| 700 | 1 | a Kuh, Diana4 aut |
| 700 | 1 | a Kuusisto, Johanna4 aut |
| 700 | 1 | a Kyvik, Kirsten O.4 aut |
| 700 | 1 | a Laakso, Markku4 aut |
| 700 | 1 | a Lakka, Timo A.4 aut |
| 700 | 1 | a Lind, Larsu Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)larslind |
| 700 | 1 | a Lindgren, Cecilia M.4 aut |
| 700 | 1 | a Martin, Nicholas G.4 aut |
| 700 | 1 | a Maerz, Winfried4 aut |
| 700 | 1 | a McCarthy, Mark I.4 aut |
| 700 | 1 | a McKenzie, Colin A.4 aut |
| 700 | 1 | a Meneton, Pierre4 aut |
| 700 | 1 | a Metspalu, Andres4 aut |
| 700 | 1 | a Moilanen, Leena4 aut |
| 700 | 1 | a Morris, Andrew D.4 aut |
| 700 | 1 | a Munroe, Patricia B.4 aut |
| 700 | 1 | a Njolstad, Inger4 aut |
| 700 | 1 | a Pedersen, Nancy L.4 aut |
| 700 | 1 | a Power, Chris4 aut |
| 700 | 1 | a Pramstaller, Peter P.4 aut |
| 700 | 1 | a Price, Jackie F.4 aut |
| 700 | 1 | a Psaty, Bruce M.4 aut |
| 700 | 1 | a Quertermous, Thomas4 aut |
| 700 | 1 | a Rauramaa, Rainer4 aut |
| 700 | 1 | a Saleheen, Danish4 aut |
| 700 | 1 | a Salomaa, Veikko4 aut |
| 700 | 1 | a Sanghera, Dharambir K.4 aut |
| 700 | 1 | a Saramies, Jouko4 aut |
| 700 | 1 | a Schwarz, Peter E. H.4 aut |
| 700 | 1 | a Sheu, Wayne H-H4 aut |
| 700 | 1 | a Shuldiner, Alan R.4 aut |
| 700 | 1 | a Siegbahn, Agnetau Uppsala universitet,Molekylär epidemiologi,Uppsala kliniska forskningscentrum (UCR),Koagulation och inflammationsvetenskap4 aut0 (Swepub:uu)agsie424 |
| 700 | 1 | a Spector, Tim D.4 aut |
| 700 | 1 | a Stefansson, Kari4 aut |
| 700 | 1 | a Strachan, David P.4 aut |
| 700 | 1 | a Tayo, Bamidele O.4 aut |
| 700 | 1 | a Tremoli, Elena4 aut |
| 700 | 1 | a Tuomilehto, Jaakko4 aut |
| 700 | 1 | a Uusitupa, Matti4 aut |
| 700 | 1 | a van Duijn, Cornelia M.4 aut |
| 700 | 1 | a Vollenweider, Peter4 aut |
| 700 | 1 | a Wallentin, Larsu Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi4 aut0 (Swepub:uu)larswall |
| 700 | 1 | a Wareham, Nicholas J.4 aut |
| 700 | 1 | a Whitfield, John B.4 aut |
| 700 | 1 | a Wolffenbuttel, Bruce H. R.4 aut |
| 700 | 1 | a Ordovas, Jose M.4 aut |
| 700 | 1 | a Boerwinkle, Eric4 aut |
| 700 | 1 | a Palmer, Colin N. A.4 aut |
| 700 | 1 | a Thorsteinsdottir, Unnur4 aut |
| 700 | 1 | a Chasman, Daniel I.4 aut |
| 700 | 1 | a Rotter, Jerome I.4 aut |
| 700 | 1 | a Franks, Paulu Umeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Medicin,Lunds universitet, Harvard University4 aut0 (Swepub:umu)pafr0003 |
| 700 | 1 | a Ripatti, Samuli4 aut |
| 700 | 1 | a Cupples, L. Adrienne4 aut |
| 700 | 1 | a Sandhu, Manjinder S.4 aut |
| 700 | 1 | a Rich, Stephen S.4 aut |
| 700 | 1 | a Boehnke, Michael4 aut |
| 700 | 1 | a Deloukas, Panos4 aut |
| 700 | 1 | a Kathiresan, Sekar4 aut |
| 700 | 1 | a Mohlke, Karen L.4 aut |
| 700 | 1 | a Ingelsson, Eriku Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)ering425 |
| 700 | 1 | a Abecasis, Goncalo R.4 aut |
| 710 | 2 | a Uppsala universitetb Molekylär epidemiologi4 org |
| 773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 45:11, s. 1274-1283q 45:11<1274-1283x 1061-4036x 1546-1718 |
| 856 | 4 | u https://europepmc.org/articles/pmc3838666?pdf=render |
| 856 | 4 | u http://dx.doi.org/10.1038/ng.2797y FULLTEXT |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-211783 |
| 856 | 4 8 | u https://doi.org/10.1038/ng.2797 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/4204583 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:127684100 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-83626 |
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