Search: (WFRF:(Holmes Michael V)) pers:(Dominiczak Anna F.) > Gene-centric Meta-a...
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000 | 08070naa a2201921 4500 | |
001 | oai:lup.lub.lu.se:9ff78ce1-5738-4c31-8c05-df340032750d | |
003 | SwePub | |
008 | 160401s2014 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/43341542 URI |
024 | 7 | a https://doi.org/10.1016/j.ajhg.2013.12.0162 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Tragante, Vinicius4 aut |
245 | 1 0 | a Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci. |
264 | 1 | b Elsevier BV,c 2014 |
520 | a Blood pressure (BP) is a heritable risk factor for cardiovascular disease. To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP), we genotyped ∼50,000 SNPs in up to 87,736 individuals of European ancestry and combined these in a meta-analysis. We replicated findings in an independent set of 68,368 individuals of European ancestry. Our analyses identified 11 previously undescribed associations in independent loci containing 31 genes including PDE1A, HLA-DQB1, CDK6, PRKAG2, VCL, H19, NUCB2, RELA, HOXC@ complex, FBN1, and NFAT5 at the Bonferroni-corrected array-wide significance threshold (p < 6 × 10(-7)) and confirmed 27 previously reported associations. Bioinformatic analysis of the 11 loci provided support for a putative role in hypertension of several genes, such as CDK6 and NUCB2. Analysis of potential pharmacological targets in databases of small molecules showed that ten of the genes are predicted to be a target for small molecules. In summary, we identified previously unknown loci associated with BP. Our findings extend our understanding of genes involved in BP regulation, which may provide new targets for therapeutic intervention or drug response stratification. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Barnes, Michael R4 aut |
700 | 1 | a Ganesh, Santhi K4 aut |
700 | 1 | a Lanktree, Matthew B4 aut |
700 | 1 | a Guo, Wei4 aut |
700 | 1 | a Franceschini, Nora4 aut |
700 | 1 | a Smith, Erin N4 aut |
700 | 1 | a Johnson, Toby4 aut |
700 | 1 | a Holmes, Michael V4 aut |
700 | 1 | a Padmanabhan, Sandosh4 aut |
700 | 1 | a Karczewski, Konrad J4 aut |
700 | 1 | a Almoguera, Berta4 aut |
700 | 1 | a Barnard, John4 aut |
700 | 1 | a Baumert, Jens4 aut |
700 | 1 | a Chang, Yen-Pei Christy4 aut |
700 | 1 | a Elbers, Clara C4 aut |
700 | 1 | a Farrall, Martin4 aut |
700 | 1 | a Fischer, Mary E4 aut |
700 | 1 | a Gaunt, Tom R4 aut |
700 | 1 | a Gho, Johannes M I H4 aut |
700 | 1 | a Gieger, Christian4 aut |
700 | 1 | a Goel, Anuj4 aut |
700 | 1 | a Gong, Yan4 aut |
700 | 1 | a Isaacs, Aaron4 aut |
700 | 1 | a Kleber, Marcus E4 aut |
700 | 1 | a Leach, Irene Mateo4 aut |
700 | 1 | a McDonough, Caitrin W4 aut |
700 | 1 | a Meijs, Matthijs F L4 aut |
700 | 1 | a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome |
700 | 1 | a Nelson, Christopher P4 aut |
700 | 1 | a Nolte, Ilja M4 aut |
700 | 1 | a Pankratz, Nathan4 aut |
700 | 1 | a Price, Tom S4 aut |
700 | 1 | a Shaffer, Jonathan4 aut |
700 | 1 | a Shah, Sonia4 aut |
700 | 1 | a Tomaszewski, Maciej4 aut |
700 | 1 | a van der Most, Peter J4 aut |
700 | 1 | a Van Iperen, Erik P A4 aut |
700 | 1 | a Vonk, Judith M4 aut |
700 | 1 | a Witkowska, Kate4 aut |
700 | 1 | a Wong, Caroline O L4 aut |
700 | 1 | a Zhang, Li4 aut |
700 | 1 | a Beitelshees, Amber L4 aut |
700 | 1 | a Berenson, Gerald S4 aut |
700 | 1 | a Bhatt, Deepak L4 aut |
700 | 1 | a Brown, Morris4 aut |
700 | 1 | a Burt, Amber4 aut |
700 | 1 | a Cooper-Dehoff, Rhonda M4 aut |
700 | 1 | a Connell, John M4 aut |
700 | 1 | a Cruickshanks, Karen J4 aut |
700 | 1 | a Curtis, Sean P4 aut |
700 | 1 | a Davey-Smith, George4 aut |
700 | 1 | a Delles, Christian4 aut |
700 | 1 | a Gansevoort, Ron T4 aut |
700 | 1 | a Guo, Xiuqing4 aut |
700 | 1 | a Haiqing, Shen4 aut |
700 | 1 | a Hastie, Claire E4 aut |
700 | 1 | a Hofker, Marten H4 aut |
700 | 1 | a Hovingh, G Kees4 aut |
700 | 1 | a Kim, Daniel S4 aut |
700 | 1 | a Kirkland, Susan A4 aut |
700 | 1 | a Klein, Barbara E4 aut |
700 | 1 | a Klein, Ronald4 aut |
700 | 1 | a Li, Yun R4 aut |
700 | 1 | a Maiwald, Steffi4 aut |
700 | 1 | a Newton-Cheh, Christopher4 aut |
700 | 1 | a O'Brien, Eoin T4 aut |
700 | 1 | a Onland-Moret, N Charlotte4 aut |
700 | 1 | a Palmas, Walter4 aut |
700 | 1 | a Parsa, Afshin4 aut |
700 | 1 | a Penninx, Brenda W4 aut |
700 | 1 | a Pettinger, Mary4 aut |
700 | 1 | a Vasan, Ramachandran S4 aut |
700 | 1 | a Ranchalis, Jane E4 aut |
700 | 1 | a M Ridker, Paul4 aut |
700 | 1 | a Rose, Lynda M4 aut |
700 | 1 | a Sever, Peter4 aut |
700 | 1 | a Shimbo, Daichi4 aut |
700 | 1 | a Steele, Laura4 aut |
700 | 1 | a Stolk, Ronald P4 aut |
700 | 1 | a Thorand, Barbara4 aut |
700 | 1 | a Trip, Mieke D4 aut |
700 | 1 | a van Duijn, Cornelia M4 aut |
700 | 1 | a Verschuren, W Monique4 aut |
700 | 1 | a Wijmenga, Cisca4 aut |
700 | 1 | a Wyatt, Sharon4 aut |
700 | 1 | a Young, J Hunter4 aut |
700 | 1 | a Zwinderman, Aeilko H4 aut |
700 | 1 | a Bezzina, Connie R4 aut |
700 | 1 | a Boerwinkle, Eric4 aut |
700 | 1 | a Casas, Juan P4 aut |
700 | 1 | a Caulfield, Mark J4 aut |
700 | 1 | a Chakravarti, Aravinda4 aut |
700 | 1 | a Chasman, Daniel I4 aut |
700 | 1 | a Davidson, Karina W4 aut |
700 | 1 | a Doevendans, Pieter A4 aut |
700 | 1 | a Dominiczak, Anna F4 aut |
700 | 1 | a Fitzgerald, Garret A4 aut |
700 | 1 | a Gums, John G4 aut |
700 | 1 | a Fornage, Myriam4 aut |
700 | 1 | a Hakonarson, Hakon4 aut |
700 | 1 | a Halder, Indrani4 aut |
700 | 1 | a Hillege, Hans L4 aut |
700 | 1 | a Illig, Thomas4 aut |
700 | 1 | a Jarvik, Gail P4 aut |
700 | 1 | a Johnson, Julie A4 aut |
700 | 1 | a Kastelein, John J P4 aut |
700 | 1 | a Koenig, Wolfgang4 aut |
700 | 1 | a Kumari, Meena4 aut |
700 | 1 | a März, Winfried4 aut |
700 | 1 | a Murray, Sarah S4 aut |
700 | 1 | a O'Connell, Jeffery R4 aut |
700 | 1 | a Oldehinkel, Albertine J4 aut |
700 | 1 | a Pankow, James S4 aut |
700 | 1 | a Rader, Daniel J4 aut |
700 | 1 | a Redline, Susan4 aut |
700 | 1 | a Reilly, Muredach P4 aut |
700 | 1 | a Schadt, Eric E4 aut |
700 | 1 | a Kottke-Marchant, Kandice4 aut |
700 | 1 | a Snieder, Harold4 aut |
700 | 1 | a Snyder, Michael4 aut |
700 | 1 | a Stanton, Alice V4 aut |
700 | 1 | a Tobin, Martin D4 aut |
700 | 1 | a Uitterlinden, André G4 aut |
700 | 1 | a van der Harst, Pim4 aut |
700 | 1 | a van der Schouw, Yvonne T4 aut |
700 | 1 | a Samani, Nilesh J4 aut |
700 | 1 | a Watkins, Hugh4 aut |
700 | 1 | a Johnson, Andrew D4 aut |
700 | 1 | a Reiner, Alex P4 aut |
700 | 1 | a Zhu, Xiaofeng4 aut |
700 | 1 | a de Bakker, Paul I W4 aut |
700 | 1 | a Levy, Daniel4 aut |
700 | 1 | a Asselbergs, Folkert W4 aut |
700 | 1 | a Munroe, Patricia B4 aut |
700 | 1 | a Keating, Brendan J4 aut |
710 | 2 | a Kardiovaskulär forskning - hypertonib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t American Journal of Human Geneticsd : Elsevier BVg 94:3, s. 349-360q 94:3<349-360x 0002-9297 |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/24560520?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1016/j.ajhg.2013.12.016y FULLTEXT |
856 | 4 | u http://www.cell.com/article/S0002929713006137/pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/4334154 |
856 | 4 8 | u https://doi.org/10.1016/j.ajhg.2013.12.016 |
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