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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04631naa a2200709 4500 | |
| 001 | oai:DiVA.org:umu-152380 | |
| 003 | SwePub | |
| 008 | 181005s2018 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:139182467 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1523802 URI |
| 024 | 7 | a https://doi.org/10.1007/s11306-018-1412-22 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1391824672 URI |
| 040 | a (SwePub)umud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Brandsma, Joost4 aut |
| 245 | 1 0 | a Lipid phenotyping of lung epithelial lining fluid in healthy human volunteers |
| 264 | c 2018-09-17 | |
| 264 | 1 | b Springer-Verlag New York,c 2018 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Background: Lung epithelial lining fluid (ELF)-sampled through sputum induction-is a medium rich in cells, proteins and lipids. However, despite its key role in maintaining lung function, homeostasis and defences, the composition and biology of ELF, especially in respect of lipids, remain incompletely understood. Objectives: To characterise the induced sputum lipidome of healthy adult individuals, and to examine associations between different ELF lipid phenotypes and the demographic characteristics within the study cohort.Methods: Induced sputum samples were obtained from 41 healthy non-smoking adults, and their lipid compositions analysed using a combination of untargeted shotgun and liquid chromatography mass spectrometry methods. Topological data analysis (TDA) was used to group subjects with comparable sputum lipidomes in order to identify distinct ELF phenotypes.Results: The induced sputum lipidome was diverse, comprising a range of different molecular classes, including at least 75 glycerophospholipids, 13 sphingolipids, 5 sterol lipids and 12 neutral glycerolipids. TDA identified two distinct phenotypes differentiated by a higher total lipid content and specific enrichments of diacyl-glycerophosphocholines, -inositols and -glycerols in one group, with enrichments of sterols, glycolipids and sphingolipids in the other. Subjects presenting the lipid-rich ELF phenotype also had significantly higher BMI, but did not differ in respect of other demographic characteristics such as age or gender.Conclusions: We provide the first evidence that the ELF lipidome varies significantly between healthy individuals and propose that such differences are related to weight status, highlighting the potential impact of (over)nutrition on lung lipid metabolism. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
| 653 | a Induced sputum | |
| 653 | a Epithelial lining fluid | |
| 653 | a Pulmonary surfactant | |
| 653 | a Lipid metabolism | |
| 653 | a Lipidomics | |
| 653 | a Mass spectrometry | |
| 653 | a Weight status | |
| 700 | 1 | a Goss, Victoria M.4 aut |
| 700 | 1 | a Yang, Xian4 aut |
| 700 | 1 | a Bakke, Per S.4 aut |
| 700 | 1 | a Caruso, Massimo4 aut |
| 700 | 1 | a Chanez, Pascal4 aut |
| 700 | 1 | a Dahlén, Sven-Eriku Karolinska Institutet4 aut |
| 700 | 1 | a Fowler, Stephen J.4 aut |
| 700 | 1 | a Horvath, Ildiko4 aut |
| 700 | 1 | a Krug, Norbert4 aut |
| 700 | 1 | a Montuschi, Paolo4 aut |
| 700 | 1 | a Sanak, Marek4 aut |
| 700 | 1 | a Sandström, Thomas,d 1957-u Umeå universitet,Avdelningen för medicin4 aut0 (Swepub:umu)thsa0001 |
| 700 | 1 | a Shaw, Dominick E.4 aut |
| 700 | 1 | a Chung, Kian Fan4 aut |
| 700 | 1 | a Singer, Florian4 aut |
| 700 | 1 | a Fleming, Louise J.4 aut |
| 700 | 1 | a Sousa, Ana R.4 aut |
| 700 | 1 | a Pandis, Ioannis4 aut |
| 700 | 1 | a Bansal, Aruna T.4 aut |
| 700 | 1 | a Sterk, Peter J.4 aut |
| 700 | 1 | a Djukanovic, Ratko4 aut |
| 700 | 1 | a Postle, Anthony D.4 aut |
| 710 | 2 | a Karolinska Institutetb Avdelningen för medicin4 org |
| 773 | 0 | t Metabolomicsd : Springer-Verlag New Yorkg 14:10q 14:10x 1573-3882x 1573-3890 |
| 856 | 4 | u https://doi.org/10.1007/s11306-018-1412-2y Fulltext |
| 856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1253746/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://link.springer.com/content/pdf/10.1007/s11306-018-1412-2.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-152380 |
| 856 | 4 8 | u https://doi.org/10.1007/s11306-018-1412-2 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:139182467 |
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