Sökning: (WFRF:(Kircher Tilo T J)) pers:(Fullerton Janice M) >
Fältnamn | Indikatorer | Metadata |
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000 | 06428naa a2201225 4500 | |
001 | oai:gup.ub.gu.se/312374 | |
003 | SwePub | |
008 | 240910s2022 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:148341595 | |
024 | 7 | a https://gup.ub.gu.se/publication/3123742 URI |
024 | 7 | a https://doi.org/10.1111/bdi.131722 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1483415952 URI |
040 | a (SwePub)gud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a McWhinney, Sean R4 aut |
245 | 1 0 | a Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness-ENIGMA study in 2436 individuals. |
264 | c 2021-12-16 | |
264 | 1 | b Wiley,c 2022 |
520 | a Rates of obesity have reached epidemic proportions, especially among people with psychiatric disorders. While the effects of obesity on the brain are of major interest in medicine, they remain markedly under-researched in psychiatry.We obtained body mass index (BMI) and magnetic resonance imaging-derived regional cortical thickness, surface area from 836 bipolar disorders (BD) and 1600 control individuals from 14sites within the ENIGMA-BD Working Group. We identified regionally specific profiles of cortical thickness using K-means clustering and studied clinical characteristics associated with individual cortical profiles.We detected two clusters based on similarities among participants in cortical thickness. The lower thickness cluster (46.8% of the sample) showed thinner cortex, especially in the frontal and temporal lobes and was associated with diagnosis of BD, higher BMI, and older age. BD individuals in the low thickness cluster were more likely to have the diagnosis of bipolar disorder I and less likely to be treated with lithium. In contrast, clustering based on similarities in the cortical surface area was unrelated to BD or BMI and only tracked age and sex.We provide evidence that both BD and obesity are associated with similar alterations in cortical thickness, but not surface area. The fact that obesity increased the chance of having low cortical thickness could explain differences in cortical measures among people with BD. The thinner cortex in individuals with higher BMI, which was additive and similar to the BD-associated alterations, may suggest that treating obesity could lower the extent of cortical thinning in BD. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
700 | 1 | a Abé, Christophu Karolinska Institutet4 aut |
700 | 1 | a Alda, Martin4 aut |
700 | 1 | a Benedetti, Francesco4 aut |
700 | 1 | a Bøen, Erlend4 aut |
700 | 1 | a Del Mar Bonnin, Caterina4 aut |
700 | 1 | a Borgers, Tiana4 aut |
700 | 1 | a Brosch, Katharina4 aut |
700 | 1 | a Canales-Rodríguez, Erick J4 aut |
700 | 1 | a Cannon, Dara M4 aut |
700 | 1 | a Dannlowski, Udo4 aut |
700 | 1 | a Diaz-Zuluaga, Ana M4 aut |
700 | 1 | a Dietze, Lorielle4 aut |
700 | 1 | a Elvsåshagen, Torbjørn4 aut |
700 | 1 | a Eyler, Lisa T4 aut |
700 | 1 | a Fullerton, Janice M4 aut |
700 | 1 | a Goikolea, Jose M4 aut |
700 | 1 | a Goltermann, Janik4 aut |
700 | 1 | a Grotegerd, Dominik4 aut |
700 | 1 | a Haarman, Bartholomeus C M4 aut |
700 | 1 | a Hahn, Tim4 aut |
700 | 1 | a Howells, Fleur M4 aut |
700 | 1 | a Ingvar, Martinu Karolinska Institutet4 aut |
700 | 1 | a Kircher, Tilo T J4 aut |
700 | 1 | a Krug, Axel4 aut |
700 | 1 | a Kuplicki, Rayus T4 aut |
700 | 1 | a Landén, Mikael,d 1966u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlandt |
700 | 1 | a Lemke, Hannah4 aut |
700 | 1 | a Liberg, Benny4 aut |
700 | 1 | a Lopez-Jaramillo, Carlos4 aut |
700 | 1 | a Malt, Ulrik F4 aut |
700 | 1 | a Martyn, Fiona M4 aut |
700 | 1 | a Mazza, Elena4 aut |
700 | 1 | a McDonald, Colm4 aut |
700 | 1 | a McPhilemy, Genevieve4 aut |
700 | 1 | a Meier, Sandra4 aut |
700 | 1 | a Meinert, Susanne4 aut |
700 | 1 | a Meller, Tina4 aut |
700 | 1 | a Melloni, Elisa M T4 aut |
700 | 1 | a Mitchell, Philip B4 aut |
700 | 1 | a Nabulsi, Leila4 aut |
700 | 1 | a Nenadic, Igor4 aut |
700 | 1 | a Opel, Nils4 aut |
700 | 1 | a Ophoff, Roel A4 aut |
700 | 1 | a Overs, Bronwyn J4 aut |
700 | 1 | a Pfarr, Julia-Katharina4 aut |
700 | 1 | a Pineda-Zapata, Julian A4 aut |
700 | 1 | a Pomarol-Clotet, Edith4 aut |
700 | 1 | a Raduà, Joaquimu Karolinska Institutet4 aut |
700 | 1 | a Repple, Jonathan4 aut |
700 | 1 | a Richter, Maike4 aut |
700 | 1 | a Ringwald, Kai G4 aut |
700 | 1 | a Roberts, Gloria4 aut |
700 | 1 | a Ross, Alex4 aut |
700 | 1 | a Salvador, Raymond4 aut |
700 | 1 | a Savitz, Jonathan4 aut |
700 | 1 | a Schmitt, Simon4 aut |
700 | 1 | a Schofield, Peter R4 aut |
700 | 1 | a Sim, Kang4 aut |
700 | 1 | a Stein, Dan J4 aut |
700 | 1 | a Stein, Frederike4 aut |
700 | 1 | a Temmingh, Henk S4 aut |
700 | 1 | a Thiel, Katharina4 aut |
700 | 1 | a Thomopoulos, Sophia I4 aut |
700 | 1 | a van Haren, Neeltje E M4 aut |
700 | 1 | a Van Gestel, Holly4 aut |
700 | 1 | a Vargas, Cristian4 aut |
700 | 1 | a Vieta, Eduard4 aut |
700 | 1 | a Vreeker, Annabel4 aut |
700 | 1 | a Waltemate, Lena4 aut |
700 | 1 | a Yatham, Lakshmi N4 aut |
700 | 1 | a Ching, Christopher R K4 aut |
700 | 1 | a Andreassen, Ole A4 aut |
700 | 1 | a Thompson, Paul M4 aut |
700 | 1 | a Hajek, Tomas4 aut |
710 | 2 | a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t Bipolar disordersd : Wileyg 24:5, s. 509-520q 24:5<509-520x 1399-5618x 1398-5647 |
856 | 4 8 | u https://gup.ub.gu.se/publication/312374 |
856 | 4 8 | u https://doi.org/10.1111/bdi.13172 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:148341595 |
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