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Avoiding Routine Ox...
Avoiding Routine Oxygen Therapy in Patients With Myocardial Infarction Saves Significant Expenditure for the Health Care System—Insights From the Randomized DETO2X-AMI Trial
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- Hofmann, Robin (author)
- Karolinska Institutet,Karolinska Institute
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- Abebe, Tamrat Befekadu (author)
- Uppsala universitet,Uppsala University,Kardiologi
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- Herlitz, Johan, 1949- (author)
- Högskolan i Borås,Akademin för vård, arbetsliv och välfärd,University of Borås, Sweden
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- James, Stefan K., 1964- (author)
- Uppsala universitet,Uppsala University,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Erlinge, David (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Molecular Cardiology,Lund University Research Groups
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- Alfredsson, Joakim (author)
- Linköping University,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US,Linköping University Hospital
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- Jernberg, Tomas (author)
- Karolinska Institutet
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- Kellerth, Thomas (author)
- Örebro University
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- Ravn-Fischer, Annica, 1974 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Lindahl, Bertil, 1957- (author)
- Uppsala universitet,Uppsala University,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Langenskiöld, Sophie, 1968- (author)
- Uppsala universitet,Uppsala University,Kardiologi
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(creator_code:org_t)
- 2022-01-12
- 2022
- English.
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In: Frontiers in Public Health. - Lausanne, Switzerland : Frontiers Media SA. - 2296-2565. ; 9
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Abstract
Subject headings
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- Background: Myocardial infarction (MI) occurs frequently and requires considerable health care resources. It is important to ensure that the treatments which are provided are both clinically effective and economically justifiable. Based on recent new evidence, routine oxygen therapy is no longer recommended in MI patients without hypoxemia. By using data from a nationwide randomized clinical trial, we estimated oxygen therapy related cost savings in this important clinical setting. Methods: The DETermination of the role of Oxygen in suspected Acute Myocardial Infarction (DETO2X-AMI) trial randomized 6,629 patients from 35 hospitals across Sweden to oxygen at 6 L/min for 6–12 h or ambient air. Costs for drug and medical supplies, and labor were calculated per patient, for the whole study population, and for the total annual care episodes for MI in Sweden (N = 16,100) with 10 million inhabitants. Results: Per patient, costs were estimated to 36 USD, summing up to a total cost of 119,832 USD for the whole study population allocated to oxygen treatment. Applied to the annual care episodes for MI in Sweden, costs sum up to between 514,060 and 604,777 USD. In the trial, 62 (2%) patients assigned to oxygen and 254 (8%) patients assigned to ambient air developed hypoxemia. A threshold analysis suggested that up to a cut-off of 624 USD spent for hypoxemia treatment related costs per patient, avoiding routine oxygen therapy remains cost saving. Conclusions: Avoiding routine oxygen therapy in patients with suspected or confirmed MI without hypoxemia at baseline saves significant expenditure for the health care system both with regards to medical and human resources. Clinical Trial Registration: ClinicalTrials.gov, identifier: NCT01787110. Copyright © 2022 Hofmann, Abebe, Herlitz, James, Erlinge, Alfredsson, Jernberg, Kellerth, Ravn-Fischer, Lindahl, Langenskiöld and DETO2X-SWEDEHEART Investigators.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- health care costs and utilization
- myocardial infarction
- oxygen therapy
- pragmatic clinical trial
- randomized clinical trial (RCT)
- registries (MeSH)
- Människan i vården
- The Human Perspective in Care
- health care costs and utilization
- myocardial infarction
- oxygen therapy
- pragmatic clinical trial
- randomized clinical trial (RCT)
- registries (MeSH)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Hofmann, Robin
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Abebe, Tamrat Be ...
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Herlitz, Johan, ...
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James, Stefan K. ...
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Erlinge, David
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Alfredsson, Joak ...
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Jernberg, Tomas
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Kellerth, Thomas
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Ravn-Fischer, An ...
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Lindahl, Bertil, ...
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Langenskiöld, So ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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Frontiers in Pub ...
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University of Borås
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Linköping University
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Lund University
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Uppsala University
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Karolinska Institutet
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University of Gothenburg