Polymorphisms of H. pylori signaling pathway genes and gastric cancer risk in the European EPIC-eurgast cohort

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Fältnamn	Indikatorer	Metadata
000		05092naa a2200925 4500
001		oai:DiVA.org:umu-76659
003		SwePub
008		130709s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-766592 URI
024	7	a https://doi.org/10.1002/ijc.283572 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Companioni, Osmel4 aut
245	1 0	a Polymorphisms of H. pylori signaling pathway genes and gastric cancer risk in the European EPIC-eurgast cohort
264		c 2013-08-13
264	1	b Wiley-Blackwell,c 2014
338		a print2 rdacarrier
500		a Article first published online: 13 Aug 2013
520		a Helicobacter pylori is a recognized causal factor of noncardia gastric cancer (GC). Lipopolysaccaride and peptidoglycan of this bacterium are recognized by CD14, TLR4 and NOD2 human proteins, while NFKB1 activates the transcription of pro-inflammatory cytokines to elicit an immune response. SNPs in these genes have been associated with GC in different populations. We genotyped 30 SNPs of these genes, in 365 gastric adenocarcinomas and 1284 matched controls from the EPIC cohort. The association with GC and its histological and anatomical subtypes was analyzed by logistic regression and corrected for multiple comparisons. Using a log-additive model we found a significant association between SNPs in CD14, NOD2 and TLR4 with GC risk. However, after applying the multiple comparisons tests only the NOD2 region remained significant (p=0.009). Analysis according to anatomical subtypes revealed NOD2 and NFKB1 SNPs associated with noncardia GC and CD14 SNPs associated with cardia GC, while analysis according to histological subtypes showed that CD14 was associated with intestinal but not diffuse GC. The multiple comparisons tests confirmed the association of NOD2 with noncardia GC (p=0.0003) and CD14 with cardia GC (p=0.01). Haplotype analysis was in agreement with single SNP results for NOD2 and CD14 genes. From these results we conclude that genetic variation in NOD2 associates with noncardia GC while variation in CD14 is associated with cardia GC.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
653		a gastric cancer
653		a genetic susceptibility
653		a Helicobacter pylori
653		a NOD2
653		a CD14
700	1	a Bonet, Catalina4 aut
700	1	a Muñoz, Xavier4 aut
700	1	a Weiderpass, Elisabete4 aut
700	1	a Panico, Salvatore4 aut
700	1	a Tumino, Rosario4 aut
700	1	a Palli, Domenico4 aut
700	1	a Agnoli, Claudia4 aut
700	1	a Vineis, Paolo4 aut
700	1	a Boutron-Ruault, Marie-Christine4 aut
700	1	a Racine, Antoine4 aut
700	1	a Clavel-Chapelon, Françoise4 aut
700	1	a Travis, Ruth C4 aut
700	1	a Khaw, Kay-Tee4 aut
700	1	a Riboli, Elio4 aut
700	1	a Murphy, Neil4 aut
700	1	a Vergnaud, Anne-Claire4 aut
700	1	a Trichopoulou, Antonia4 aut
700	1	a Benetou, Vassiliki4 aut
700	1	a Trichopoulos, Dimitrios4 aut
700	1	a Lund, Eiliv4 aut
700	1	a Johansen, Dorthe4 aut
700	1	a Lindkvist, Björn4 aut
700	1	a Johansson, Mattiasu Umeå universitet,Enheten för biobanksforskning,International Agency for Research on Cancer (IARC-WHO), Lyon, France4 aut0 (Swepub:umu)masmas97
700	1	a Sund, Malin,d 1972-u Umeå universitet,Kirurgi4 aut0 (Swepub:umu)masu0021
700	1	a Ardanaz, Eva4 aut
700	1	a Sánchez-Cantalejo, Emilio4 aut
700	1	a Huerta, Jose M4 aut
700	1	a Dorronsoro, Miren4 aut
700	1	a Quirós, José Ramón4 aut
700	1	a Tjonneland, Anne4 aut
700	1	a Mortensen, Lotte Maxild4 aut
700	1	a Overvad, Kim4 aut
700	1	a Chang-Claude, Jenny4 aut
700	1	a Rizzato, Cosmeri4 aut
700	1	a Boeing, Heiner4 aut
700	1	a de Mesquita, H Bas Bueno4 aut
700	1	a Siersema, Peter4 aut
700	1	a Peeters, Petra Hm4 aut
700	1	a Numans, Mattijs E4 aut
700	1	a Carneiro, Fatima4 aut
700	1	a Licaj, Idlir4 aut
700	1	a Freisling, Heinz4 aut
700	1	a Sala, Núria4 aut
700	1	a González, Carlos A4 aut
710	2	a Umeå universitetb Enheten för biobanksforskning4 org
773	0	t International Journal of Cancerd : Wiley-Blackwellg 134:1, s. 92-101q 134:1<92-101x 0020-7136x 1097-0215
856	4	u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.28357
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-76659
856	4 8	u https://doi.org/10.1002/ijc.28357

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Av författaren/redakt...: Companioni, Osme ...; Bonet, Catalina; Muñoz, Xavier; Weiderpass, Elis ...; Panico, Salvator ...; Tumino, Rosario; visa fler...; Palli, Domenico; Agnoli, Claudia; Vineis, Paolo; Boutron-Ruault, ...; Racine, Antoine; Clavel-Chapelon, ...; Travis, Ruth C; Khaw, Kay-Tee; Riboli, Elio; Murphy, Neil; Vergnaud, Anne-C ...; Trichopoulou, An ...; Benetou, Vassili ...; Trichopoulos, Di ...; Lund, Eiliv; Johansen, Dorthe; Lindkvist, Björn; Johansson, Matti ...; Sund, Malin, 197 ...; Ardanaz, Eva; Sánchez-Cantalej ...; Huerta, Jose M; Dorronsoro, Mire ...; Quirós, José Ram ...; Tjonneland, Anne; Mortensen, Lotte ...; Overvad, Kim; Chang-Claude, Je ...; Rizzato, Cosmeri; Boeing, Heiner; de Mesquita, H B ...; Siersema, Peter; Peeters, Petra H ...; Numans, Mattijs ...; Carneiro, Fatima; Licaj, Idlir; Freisling, Heinz; Sala, Núria; González, Carlos ...; visa färre...

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