Large-scale association analyses identify host factors influencing human gut microbiome composition

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Fältnamn	Indikatorer	Metadata
000		14275naa a2201645 4500
001		oai:DiVA.org:liu-174837
003		SwePub
008		210407s2021 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
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024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1748372 URI
024	7	a https://doi.org/10.1038/s41588-020-00763-12 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1933012 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1456991302 URI
040		a (SwePub)liud (SwePub)sud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Kurilshikov, Alexanderu Univ Groningen, Netherlands4 aut
245	1 0	a Large-scale association analyses identify host factors influencing human gut microbiome composition
264		c 2021-01-18
264	1	b Nature Publishing Group,c 2021
338		a print2 rdacarrier
500		a Funding Agencies\|Cancer Research UKCancer Research UK [C18281/A19169] Funding Source: Medline; CIHRCanadian Institutes of Health Research (CIHR) [CMF108031] Funding Source: Medline; Department of HealthEuropean Commission [BRC-1215-20011] Funding Source: Medline; Medical Research CouncilUK Research & Innovation (UKRI)Medical Research Council UK (MRC)European Commission [MR/N01183X/1, MC_UU_12013/3, MC_UU_00011/6] Funding Source: Medline; NCATS NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Advancing Translational Sciences (NCATS) [UL1 TR002489] Funding Source: Medline; NHGRI NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Human Genome Research Institute (NHGRI) [U01 HG004729, U01 HG004446] Funding Source: Medline; NHLBI NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Heart Lung & Blood Institute (NHLBI) [R01 HL140976, N01HC65236, N01HC65234, N01HC65237, N01HC65226, N01HC65235, HHSN268201300005C, N01HC65233] Funding Source: Medline; NIDDK NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) [R01 DK062370, P30 DK056350, R01 DK092127] Funding Source: Medline; NIMHD NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Minority Health & Health Disparities (NIMHD) [R01 MD011389] Funding Source: Medline; NIMH NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) [U24 MH068457, RC2 MH089951, RC2 MH089995] Funding Source: Medline; NINDS NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [T32 NS095775] Funding Source: Medline; Wellcome TrustWellcome TrustEuropean Commission [202802/Z/16/Z, 204813/Z/16/Z] Funding Source: Medline
520		a To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data from 18,340 individuals (24 cohorts). Microbial composition showed high variability across cohorts: only 9 of 410 genera were detected in more than 95% of samples. A genome-wide association study of host genetic variation regarding microbial taxa identified 31 loci affecting the microbiome at a genome-wide significant (P < 5 x 10(-8)) threshold. One locus, the lactase (LCT) gene locus, reached study-wide significance (genome-wide association study signal: P = 1.28 x 10(-20)), and it showed an age-dependent association with Bifidobacterium abundance. Other associations were suggestive (1.95 x 10(-10) < P < 5 x 10(-8)) but enriched for taxa showing high heritability and for genes expressed in the intestine and brain. A phenome-wide association study and Mendelian randomization identified enrichment of microbiome trait loci in the metabolic, nutrition and environment domains and suggested the microbiome might have causal effects in ulcerative colitis and rheumatoid arthritis.
650	7	a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng
650	7	a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng
700	1	a Medina-Gomez, Carolinau Erasmus MC Univ Med Ctr, Netherlands; Erasmus MC Univ Med Ctr, Netherlands4 aut
700	1	a Bacigalupe, Rodrigou Katholieke Univ Leuven, Belgium; VIB, Belgium4 aut
700	1	a Radjabzadeh, Djawadu Erasmus MC Univ Med Ctr, Netherlands4 aut
700	1	a Wang, Junu Katholieke Univ Leuven, Belgium; VIB, Belgium; Chinese Acad Sci, Peoples R China4 aut
700	1	a Demirkan, Ayseu Univ Groningen, Netherlands; Univ Surrey, England4 aut
700	1	a Le Roy, Caroline Iu Kings Coll London, England4 aut
700	1	a Garay, Juan Antonio Raygozau Univ Toronto, Canada; Mt Sinai Hosp, Canada4 aut
700	1	a Finnicum, Casey T.u Avera McKennan Hosp, SD USA; Univ Hlth Ctr, SD USA4 aut
700	1	a Liu, Xingrongu Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Inst, Sweden4 aut
700	1	a Zhernakova, Daria Vu Univ Groningen, Netherlands; ITMO Univ, Russia4 aut
700	1	a Bonder, Marc Janu Univ Groningen, Netherlands4 aut
700	1	a Hansen, Tue H.u Univ Copenhagen, Denmark4 aut
700	1	a Frost, Fabianu Univ Med Greifswald, Germany4 aut
700	1	a Ruhlemann, Malte C.u Christian Albrechts Univ Kiel, Germany4 aut
700	1	a Turpin, Williamsu Univ Toronto, Canada; Mt Sinai Hosp, Canada4 aut
700	1	a Moon, Jee-Youngu Albert Einstein Coll Med, NY 10467 USA4 aut
700	1	a Kim, Han-Nau Sungkyunkwan Univ, South Korea; Sungkyunkwan Univ, South Korea4 aut
700	1	a Lull, Kreeteu Univ Tartu, Estonia4 aut
700	1	a Barkan, Eladu Weizmann Inst Sci, Israel4 aut
700	1	a Andreasson, Annau Karolinska Institutet,Stockholms universitet,Stressforskningsinstitutet,Copenhagen Univ Hosp, Denmark,Stockholm Univ, Sweden,Univ Bristol, England; Univ Bristol Sch Med, England,Kings Coll London, England; Univ Oxford, England,Maastricht Univ Med Ctr, Netherlands; Maastricht Univ, Netherlands,Erasmus MC Univ Med Ctr, Netherlands,Univ N Carolina, NC USA; Univ North Carolina Chapel Hill, NC USA4 aut0 (Swepub:su)anan6088
700	1	a Fornage, Myriamu Univ Texas Hlth Sci Ctr Houston, TX 77030 USA4 aut
700	1	a Szopinska-Tokov, Joannau Univ Texas Hlth Sci Ctr Houston, TX USA; Radboudumc, Netherlands4 aut
700	1	a Wallen, Zachary D.u Univ Alabama Birmingham, AL 35294 USA4 aut
700	1	a Borisevich, Dmitriiu Univ Copenhagen, Denmark4 aut
700	1	a Agreus, Larsu Karolinska Institutet,Karolinska Inst, Sweden4 aut
700	1	a Andreasson, Annau Stockholm Univ, Sweden4 aut
700	1	a Bang, Corinnau Christian Albrechts Univ Kiel, Germany4 aut
700	1	a Bedrani, Larbiu Univ Toronto, Canada4 aut
700	1	a Bell, Jordana T.u Kings Coll London, England4 aut
700	1	a Bisgaard, Hansu Copenhagen Univ Hosp, Denmark4 aut
700	1	a Boehnke, Michaelu Univ Michigan, MI 48109 USA4 aut
700	1	a Boomsma, Dorret Iu Vrije Univ, Netherlands4 aut
700	1	a Burk, Robert D.u Albert Einstein Coll Med, NY 10467 USA4 aut
700	1	a Claringbould, Anniqueu Univ Groningen, Netherlands4 aut
700	1	a Croitoru, Kennethu Univ Toronto, Canada; Mt Sinai Hosp, Canada4 aut
700	1	a Davies, Gareth E.u Avera McKennan Hosp, SD USA; Univ Hlth Ctr, SD USA; Vrije Univ, Netherlands4 aut
700	1	a van Duijn, Cornelia M.u Erasmus MC Univ Med Ctr, Netherlands; Univ Oxford, England4 aut
700	1	a Duijts, Liesbethu Erasmus MC Univ Med Ctr, Netherlands4 aut
700	1	a Falony, Gwenu Katholieke Univ Leuven, Belgium; VIB, Belgium4 aut
700	1	a Fu, Jingyuanu Univ Groningen, Netherlands4 aut
700	1	a van der Graaf, Adriaanu Univ Groningen, Netherlands4 aut
700	1	a Hansen, Torbenu Univ Copenhagen, Denmark4 aut
700	1	a Homuth, Georgu Univ Med Greifswald, Germany4 aut
700	1	a Hughes, David A.u Univ Bristol, England; Univ Bristol Sch Med, England4 aut
700	1	a Ijzerman, Richard G.u Amsterdam Univ Med Ctr, Netherlands4 aut
700	1	a Jackson, Matthew A.u Kings Coll London, England; Univ Oxford, England4 aut
700	1	a Jaddoe, Vincent W. V.u Erasmus MC Univ Med Ctr, Netherlands; Erasmus MC Univ Med Ctr, Netherlands4 aut
700	1	a Joossens, Marieu Katholieke Univ Leuven, Belgium; VIB, Belgium4 aut
700	1	a Jorgensen, Torbenu Univ Copenhagen, Denmark; Univ Copenhagen, Denmark4 aut
700	1	a Keszthelyi, Danielu Maastricht Univ Med Ctr, Netherlands; Maastricht Univ, Netherlands4 aut
700	1	a Knight, Robu Univ Calif San Diego, CA 92093 USA; Univ Calif San Diego, CA 92093 USA; Univ Calif San Diego, CA 92093 USA4 aut
700	1	a Laakso, Markkuu Univ Eastern Finland, Finland4 aut
700	1	a Laudes, Matthiasu Univ Hosp Schleswig Holstein, Germany4 aut
700	1	a Launer, Lenore J.u NIA, MD 20892 USA4 aut
700	1	a Lieb, Wolfgangu Univ Kiel, Germany4 aut
700	1	a Lusis, Aldons J.u Univ Calif Los Angeles, CA 90024 USA; Univ Calif Los Angeles, CA USA; Univ Calif Los Angeles, CA 90024 USA4 aut
700	1	a Masclee, Ad A. M.u Maastricht Univ Med Ctr, Netherlands; Maastricht Univ, Netherlands4 aut
700	1	a Moll, Henriette A.u Erasmus MC Univ Med Ctr, Netherlands4 aut
700	1	a Mujagic, Zlatanu Maastricht Univ Med Ctr, Netherlands; Maastricht Univ, Netherlands4 aut
700	1	a Qibin, Qiu Albert Einstein Coll Med, NY 10467 USA4 aut
700	1	a Rothschild, Daphnau Weizmann Inst Sci, Israel4 aut
700	1	a Shin, Hocheolu Sungkyunkwan Univ, South Korea; Sungkyunkwan Univ, South Korea4 aut
700	1	a Sorensen, Soren J.u Univ Copenhagen, Denmark4 aut
700	1	a Steves, Claire J.u Kings Coll London, England4 aut
700	1	a Thorsen, Jonathanu Copenhagen Univ Hosp, Denmark4 aut
700	1	a Timpson, Nicholas J.u Univ Bristol, England; Univ Bristol Sch Med, England4 aut
700	1	a Tito, Raul Y.u Katholieke Univ Leuven, Belgium; VIB, Belgium4 aut
700	1	a Vieira-Silva, Sarau Katholieke Univ Leuven, Belgium; VIB, Belgium4 aut
700	1	a Volker, Uweu Univ Med Greifswald, Germany4 aut
700	1	a Volzke, Henryu Univ Med Greifswald, Germany4 aut
700	1	a Vosa, Urmou Univ Groningen, Netherlands4 aut
700	1	a Wade, Kaitlin H.u Univ Bristol, England; Univ Bristol Sch Med, England4 aut
700	1	a Walter, Susannau Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken4 aut0 (Swepub:liu)suswa35
700	1	a Watanabe, Kyokou Vrije Univ Amsterdam, Netherlands4 aut
700	1	a Weiss, Stefanu Univ Med Greifswald, Germany4 aut
700	1	a Weiss, Frank U.u Univ Med Greifswald, Germany4 aut
700	1	a Weissbrod, Omeru Harvard Univ, MA 02115 USA4 aut
700	1	a Westra, Harm-Janu Univ Groningen, Netherlands4 aut
700	1	a Willemsen, Gonnekeu Vrije Univ, Netherlands4 aut
700	1	a Payami, Haydehu Univ Alabama Birmingham, AL 35294 USA4 aut
700	1	a Jonkers, Daisy M. A. E.u Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Inst, Sweden; Monash Univ, Australia; Biodonostia Hlth Res Inst, Spain; Basque Sci Fdn, Spain4 aut
700	1	a Vasquez, Alejandro Ariasu Univ Texas Hlth Sci Ctr Houston, TX USA; Radboudumc, Netherlands; Radboudumc, Netherlands4 aut
700	1	a de Geus, Eco J. C.u Vrije Univ, Netherlands; Amsterdam UMC, Netherlands4 aut
700	1	a Meyer, Katie A.u Univ N Carolina, NC USA; Univ North Carolina Chapel Hill, NC USA4 aut
700	1	a Stokholm, Jakobu Copenhagen Univ Hosp, Denmark4 aut
700	1	a Segal, Eranu Weizmann Inst Sci, Israel4 aut
700	1	a Org, Elinu Univ Tartu, Estonia4 aut
700	1	a Wijmenga, Ciscau Univ Groningen, Netherlands4 aut
700	1	a Kim, Hyung-Laeu Ewha Womans Univ, South Korea4 aut
700	1	a Kaplan, Robert C.u Fred Hutchinson Canc Res Ctr, WA USA4 aut
700	1	a Spector, Tim D.u Kings Coll London, England4 aut
700	1	a Uitterlinden, Andre G.u Erasmus MC Univ Med Ctr, Netherlands; Erasmus MC Univ Med Ctr, Netherlands; Erasmus MC Univ Med Ctr, Netherlands4 aut
700	1	a Rivadeneira, Fernandou Erasmus MC Univ Med Ctr, Netherlands; Erasmus MC Univ Med Ctr, Netherlands4 aut
700	1	a Franke, Andreu Christian Albrechts Univ Kiel, Germany4 aut
700	1	a Lerch, Markus M.u Univ Med Greifswald, Germany4 aut
700	1	a Franke, Ludeu Univ Groningen, Netherlands4 aut
700	1	a Sanna, Serenau Univ Groningen, Netherlands; CNR, Italy4 aut
700	1	a DAmato, Maurou Karolinska Inst, Sweden; Karolinska Inst, Sweden; Monash Univ, Australia; Biodonostia Hlth Res Inst, Spain; Basque Sci Fdn, Spain4 aut
700	1	a Pedersen, Olufu Univ Copenhagen, Denmark4 aut
700	1	a Paterson, Andrew D.u Hosp Sick Children Res Inst, Canada4 aut
700	1	a Kraaij, Robertu Erasmus MC Univ Med Ctr, Netherlands4 aut
700	1	a Raes, Jeroenu Katholieke Univ Leuven, Belgium; VIB, Belgium4 aut
700	1	a Zhernakova, Alexandrau Univ Groningen, Netherlands4 aut
710	2	a Univ Groningen, Netherlandsb Erasmus MC Univ Med Ctr, Netherlands; Erasmus MC Univ Med Ctr, Netherlands4 org
773	0	t Nature Geneticsd : Nature Publishing Groupg 53:2, s. 156-165q 53:2<156-165x 1061-4036x 1546-1718
856	4	u https://pure.rug.nl/ws/files/159312822/s41588_020_00763_1.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-174837
856	4 8	u https://doi.org/10.1038/s41588-020-00763-1
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-193301
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:145699130

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