Breakprone chromosome bands in fibroblasts from patients with non‐Hodgkin's lymphoma do not coincide with bands involved in primary rearrangements in non‐Hodgkin's lymphomas

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Fältnamn	Indikatorer	Metadata
000		03438naa a2200373 4500
001		oai:lup.lub.lu.se:1386705e-775a-44a0-945b-85da0b7d77fd
003		SwePub
008		181218s1988 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/1386705e-775a-44a0-945b-85da0b7d77fd2 URI
024	7	a https://doi.org/10.1111/j.1601-5223.1988.tb00193.x2 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a JOHANSSON, BERTILu Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)kgen-bjo
245	1 0	a Breakprone chromosome bands in fibroblasts from patients with non‐Hodgkin's lymphoma do not coincide with bands involved in primary rearrangements in non‐Hodgkin's lymphomas
264		c 2008-02-14
264	1	b Springer Science and Business Media LLC,c 1988
520		a The distribution of breakpoints in structural chromosome aberrations (chromatid and chromosome gaps, breaks, and exchanges) was studied in skin fibroblasts from 35 untreated patients with non‐Hodgkin's lymphoma (NHL) and 39 controls. A total of 227 aberrations in the NHL group and 260 in the control group could be assigned to specific chromosome bands. The distribution of breakpoints was nonrandom in both groups (p<0.001), with excessive breakage in 17 bands among the NHL patients and in 21 among the controls. Two of the hot spots in the NHL group (6q21,14q24) and three in the control group (2q33,6q21, 6q25) coincided with the 60 chromosome bands that are targets for primary chromosome abnormalities in NHL. We conclude that the chromosome bands involved in primary structural abnormalities in lymphoma cells are not constitutionally breakprone in NHL patients.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
700	1	a MERTENS, FREDRIKu Skåne University Hospital4 aut0 (Swepub:lu)kgen-fme
700	1	a HEIM, SVERREu Skåne University Hospital4 aut0 (Swepub:lu)klin-she
700	1	a KRISTOFFERSSON, ULFu Skåne University Hospital4 aut0 (Swepub:lu)kgen-ukr
700	1	a MANDAHL, NILSu Skåne University Hospital4 aut0 (Swepub:lu)kgen-nma
700	1	a OLSSON, HAKANu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)onk-hol
700	1	a MITELMAN, FELIXu Skåne University Hospital4 aut0 (Swepub:lu)kgen-fmi
710	2	a Avdelningen för klinisk genetikb Institutionen för laboratoriemedicin4 org
773	0	t Hereditasd : Springer Science and Business Media LLCg 109:1, s. 131-137q 109:1<131-137x 0018-0661
856	4	u http://dx.doi.org/10.1111/j.1601-5223.1988.tb00193.xy FULLTEXT
856	4	u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1601-5223.1988.tb00193.x
856	4 8	u https://lup.lub.lu.se/record/1386705e-775a-44a0-945b-85da0b7d77fd
856	4 8	u https://doi.org/10.1111/j.1601-5223.1988.tb00193.x

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Av författaren/redakt...: JOHANSSON, BERTI ...; MERTENS, FREDRIK; HEIM, SVERRE; KRISTOFFERSSON, ...; MANDAHL, NILS; OLSSON, HAKAN; visa fler...; MITELMAN, FELIX; visa färre...

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