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The Impact of Quadr...
The Impact of Quadrivalent Human Papillomavirus (HPV; Types 6, 11, 16, and 18) L1 Virus-Like Particle Vaccine on Infection and Disease Due to Oncogenic Nonvaccine HPV Types in Generally HPV-Naive Women Aged 16-26 Years
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Brown, Darron R. (author)
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Kjaer, Susanne K. (author)
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Sigurdsson, Kristjan (author)
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Iversen, Ole-Erik (author)
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Hernandez-Avila, Mauricio (author)
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Wheeler, Cosette M. (author)
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Perez, Gonzalo (author)
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Koutsky, Laura A. (author)
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Tay, Eng Hseon (author)
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Garcia, Patricia (author)
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Ault, Kevin A. (author)
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Garland, Suzanne M. (author)
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Leodolter, Sepp (author)
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- Olsson, Sven-Eric (author)
- Karolinska Institutet
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Tang, Grace W. K. (author)
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Ferris, Daron G. (author)
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Paavonen, Jorma (author)
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Steben, Marc (author)
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Bosch, F. Xavier (author)
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- Dillner, Joakim (author)
- Karolinska Institutet,Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
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Joura, Elmar A. (author)
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Kurman, Robert J. (author)
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Majewski, Slawomir (author)
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Munoz, Nubia (author)
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Myers, Evan R. (author)
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Villa, Luisa L. (author)
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Taddeo, Frank J. (author)
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Roberts, Christine (author)
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Tadesse, Amha (author)
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Bryan, Janine (author)
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Lupinacci, Lisa C. (author)
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Giacoletti, Katherine E. D. (author)
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Sings, Heather L. (author)
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James, Margaret (author)
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Hesley, Teresa M. (author)
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Barra, Eliav (author)
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(creator_code:org_t)
- Oxford University Press (OUP), 2009
- 2009
- English.
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In: Journal Of Infectious Diseases. - : Oxford University Press (OUP). - 0022-1899 .- 1537-6613. ; 199:7, s. 926-935
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http://dx.doi.org/10...
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https://academic.oup...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Background. Human papillomavirus (HPV)-6/11/16/18 vaccine reduces the risk of HPV-6/11/16/18-related cervical intraepithelial neoplasia (CIN) 1-3 or adenocarcinoma in situ (AIS). Here, its impact on CIN1-3/AIS associated with nonvaccine oncogenic HPV types was evaluated. Methods. We enrolled 17,622 women aged 16-26 years. All underwent cervicovaginal sampling and Pap testing at regular intervals for up to 4 years. HPV genotying was performed for biopsy samples, and histological diagnoses were determined by a pathology panel. Analyses were conducted among subjects who were negative for 14 HPV types on day 1. Prespecified analyses included infection of >= 6 months' duration and CIN1-3/AIS due to the 2 and 5 most common HPV types in cervical cancer after HPV types 16 and 18, as well as all tested nonvaccine types. Results. Vaccination reduced the incidence of HPV-31/45 infection by 40.3% (95% confidence interval [CI], 13.9% to 59.0%) and of CIN1-3/AIS by 43.6% (95% CI, 12.9% to 64.1%), respectively. The reduction in HPV-31/33/45/52/58 infection and CIN1-3/AIS was 25.0% (95% CI, 5.0% to 40.9%) and 29.2% (95% CI, 8.3% to 45.5%), respectively. Efficacy for CIN2-3/AIS associated with the 10 nonvaccine HPV types was 32.5% (95% CI, 6.0% to 51.9%). Reductions were most notable for HPV-31. Conclusions. HPV-6/11/16/18 vaccine reduced the risk of CIN2-3/AIS associated with nonvaccine types responsible for similar to 20% of cervical cancers. The clinical benefit of cross-protection is not expected to be fully additive to the efficacy already observed against HPV-6/11/16/18-related disease, because women may have >1 CIN lesion, each associated with a different HPV type.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
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- ref (subject category)
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- By the author/editor
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Brown, Darron R.
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Kjaer, Susanne K ...
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Sigurdsson, Kris ...
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Iversen, Ole-Eri ...
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Hernandez-Avila, ...
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Wheeler, Cosette ...
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show more...
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Perez, Gonzalo
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Koutsky, Laura A ...
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Tay, Eng Hseon
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Garcia, Patricia
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Ault, Kevin A.
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Garland, Suzanne ...
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Leodolter, Sepp
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Olsson, Sven-Eri ...
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Tang, Grace W. K ...
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Ferris, Daron G.
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Paavonen, Jorma
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Steben, Marc
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Bosch, F. Xavier
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Dillner, Joakim
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Joura, Elmar A.
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Kurman, Robert J ...
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Majewski, Slawom ...
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Munoz, Nubia
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Myers, Evan R.
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Villa, Luisa L.
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Taddeo, Frank J.
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Roberts, Christi ...
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Tadesse, Amha
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Bryan, Janine
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Lupinacci, Lisa ...
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Giacoletti, Kath ...
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Sings, Heather L ...
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James, Margaret
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Hesley, Teresa M ...
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Barra, Eliav
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
- Articles in the publication
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Journal Of Infec ...
- By the university
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Lund University
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Karolinska Institutet