Search: (WFRF:(Potash James B.)) pers:(Cruceanu Cristiana) pers:(Hauser Joanna) >
Lithium response in...
Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study
- Article/chapterEnglish2024
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/336443
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https://gup.ub.gu.se/publication/336443URI
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https://doi.org/10.1038/s41398-024-02811-4DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:238395906URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:155315598URI
Supplementary language notes
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Rosenthal, Sara B.
(author)
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Adli, Mazda
(author)
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Akiyama, Kazufumi
(author)
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Akula, Nirmala
(author)
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Alda, Martin
(author)
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Amare, Azmeraw T.
(author)
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Ardau, Raffaella
(author)
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Arias, Barbara
(author)
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Aubry, Jean-Michel
(author)
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Backlund, LenaKarolinska Institutet
(author)
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Bauer, Michael
(author)
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Baune, Bernhard T.
(author)
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Bellivier, Frank
(author)
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Benabarre, Antonio
(author)
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Bengesser, Susanne
(author)
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Bhattacharjee, Abesh Kumar
(author)
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Biernacka, Joanna M.
(author)
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Cervantes, Pablo
(author)
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Chen, Guo-Bo
(author)
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Chen, Hsi-Chung
(author)
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Chillotti, CaterinaKarolinska Institutet
(author)
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Cichon, Sven
(author)
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Clark, Scott R.
(author)
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Colom, Francesc
(author)
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Cousins, David A.
(author)
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Cruceanu, Cristiana
(author)
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Czerski, Piotr M.
(author)
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Dantas, Clarissa R.
(author)
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Dayer, Alexandre
(author)
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Del Zompo, Maria
(author)
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Degenhardt, Franziska
(author)
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DePaulo, J. Raymond
(author)
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Etain, Bruno
(author)
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Falkai, Peter
(author)
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Fellendorf, Frederike Tabea
(author)
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Ferensztajn-Rochowiak, Ewa
(author)
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Forstner, Andreas J.
(author)
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Frisen, LouiseKarolinska Institutet
(author)
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Frye, Mark A.
(author)
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Fullerton, Janice M.
(author)
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Gard, Sebastien
(author)
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Garnham, Julie S.
(author)
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Goes, Fernando S.
(author)
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Grigoroiu-Serbanescu, Maria
(author)
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Grof, Paul
(author)
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Gruber, Oliver
(author)
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Hashimoto, Ryota
(author)
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Hauser, Joanna
(author)
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Heilbronner, Urs
(author)
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Herms, Stefan
(author)
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Hoffmann, Per
(author)
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Hofmann, Andrea
(author)
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Hou, Liping
(author)
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Jamain, Stephane
(author)
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Jimenez, Esther
(author)
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Kahn, Jean-Pierre
(author)
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Kassem, Layla
(author)
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Kato, Tadafumi
(author)
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Kittel-Schneider, Sarah
(author)
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Koenig, Barbara
(author)
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Kuo, Po-Hsiu
(author)
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Kusumi, Ichiro
(author)
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Lackner, Nina
(author)
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Laje, Gonzalo
(author)
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Landén, Mikael,1966Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xlandt
(author)
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Lavebratt, Catharina
(author)
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Leboyer, Marion
(author)
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Leckband, Susan G.
(author)
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Lopez Jaramillo, Carlos A.
(author)
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MacQueen, Glenda
(author)
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Maj, MarioKarolinska Institutet
(author)
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Manchia, Mirko
(author)
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Marie-Claire, Cynthia
(author)
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Martinsson, LinaKarolinska Institutet
(author)
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Mattheisen, Manuel
(author)
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McCarthy, Michael J.
(author)
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McElroy, Susan L.
(author)
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McMahon, Francis J.
(author)
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Mitchell, Philip B.
(author)
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Mitjans, Marina
(author)
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Mondimore, Francis M.
(author)
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Monteleone, Palmiero
(author)
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Nievergelt, Caroline M.
(author)
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Noethen, Markus M.
(author)
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Novak, Tomas
(author)
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Oesby, Urban
(author)
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Ozaki, Norio
(author)
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Papiol, Sergi
(author)
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Perlis, Roy H.
(author)
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Pisanu, Claudia
(author)
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Potash, James B.
(author)
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Pfennig, Andrea
(author)
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Reich-Erkelenz, Daniela
(author)
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Reif, Andreas
(author)
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Reininghaus, Eva Z.
(author)
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Rietschel, Marcella
(author)
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Rouleau, Guy A.
(author)
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Rybakowski, Janusz K.
(author)
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Schalling, Martin
(author)
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Schofield, Peter R.
(author)
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Schubert, K. Oliver
(author)
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Schulze, Thomas G.
(author)
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Schweizer, Barbara W.
(author)
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Seemueller, Florian
(author)
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Severino, Giovanni
(author)
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Shekhtman, Tatyana
(author)
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Shilling, Paul D.
(author)
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Shimoda, Kazutaka
(author)
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Simhandl, Christian
(author)
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Slaney, Claire M.
(author)
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Squassina, Alessio
(author)
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Stamm, Thomas
(author)
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Stopkova, Pavla
(author)
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Tighe, Sarah K.
(author)
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Tortorella, Alfonso
(author)
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Turecki, Gustavo
(author)
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Vieta, Eduard
(author)
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Volkert, Julia
(author)
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Witt, Stephanie
(author)
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Wray, Naomi R.
(author)
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Wright, Adam
(author)
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Young, L. Trevor
(author)
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Zandi, Peter P.
(author)
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Kelsoe, John R.
(author)
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Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi
(creator_code:org_t)
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In:TRANSLATIONAL PSYCHIATRY14:12158-3188
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Ou, Anna H.
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