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Association between...
Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states
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Perez-Martinez, Pablo (author)
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Corella, Dolores (author)
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Shen, Jian (author)
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Arnett, Donna K. (author)
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Yiannakouris, Nikos (author)
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Tai, E. Syong (author)
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- Orho-Melander, Marju (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Tucker, Katherine L. (author)
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Tsai, Michael (author)
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Straka, Robert J. (author)
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Province, Michael (author)
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Kai, Chew Suok (author)
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Perez-Jimenez, Francisco (author)
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Lai, Chao-Qiang (author)
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Lopez-Miranda, Jose (author)
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Guillen, Marisa (author)
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Parnell, Laurence D. (author)
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Borecki, Ingrid (author)
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Kathiresan, Sekar (author)
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Ordovas, Jose M. (author)
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- English.
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In: American Journal of Clinical Nutrition. - : Elsevier BV. - 1938-3207 .- 0002-9165. ; 89:1, s. 391-399
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Abstract
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- Background: Hypertriglyceridemia is a risk factor for cardiovascular disease. Variation in the apolipoprotein A5 (APOA5) and glucokinase regulatory protein (GCKR) genes has been associated with fasting plasma triacylglycerol. Objective: We investigated the combined effects of the GCKR rs780094C -> T, APOA5 -1131T -> C, and APOA5 56C -> G single nucleotide polymorphisms (SNPs) on fasting triacylglycerol in several independent populations and the response to a high-fat meal and fenofibrate interventions. Design: We used a cross-sectional design to investigate the association with fasting triacylglycerol in 8 populations from America, Asia, and Europe (n = 7730 men and women) and 2 intervention studies in US whites (n = `1061) to examine postprandial triacylglycerol after a high-fat meal and the response to fenofibrate. We defined 3 combined genotype groups: 1) protective (homozygous for the wild-type allele for all 3 SNPs); 2) intermediate (any mixed genotype not included in groups 1 and 3); and 3) risk (carriers of the variant alleles at both genes). Results: Subjects within the risk group had significantly higher fasting triacylglycerol and a higher prevalence of hypertriglyceridemia than did subjects in the protective group across all populations. Moreover, subjects in the risk group had a greater postprandial triacylglycerol response to a high-fat meal and greater fenofibrate-induced reduction of fasting triacylglycerol than did the other groups, especially among persons with hypertriglyceridemia. Subjects with the intermediate genotype had intermediate values (P for trend < 0.001). Conclusions: SNPs in GCKR and APOA5 have an additive effect on both fasting and postprandial triacylglycerol and contribute to the interindividual variability in response to fenofibrate treatment. Am J Clin Nutr 2009;89:391-9. Clin Nutr 2009; 89: 391-9.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
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- By the author/editor
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Perez-Martinez, ...
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Corella, Dolores
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Shen, Jian
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Arnett, Donna K.
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Yiannakouris, Ni ...
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Tai, E. Syong
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show more...
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Orho-Melander, M ...
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Tucker, Katherin ...
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Tsai, Michael
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Straka, Robert J ...
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Province, Michae ...
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Kai, Chew Suok
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Perez-Jimenez, F ...
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Lai, Chao-Qiang
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Lopez-Miranda, J ...
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Guillen, Marisa
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Parnell, Laurenc ...
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Borecki, Ingrid
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Kathiresan, Seka ...
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Ordovas, Jose M.
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show less...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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American Journal ...
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Lund University